JP2024513972A - Ｒｎａサイレンシング剤および使用方法 - Google Patents

Ｒｎａサイレンシング剤および使用方法 Download PDF

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JP2024513972A
JP2024513972A JP2023562698A JP2023562698A JP2024513972A JP 2024513972 A JP2024513972 A JP 2024513972A JP 2023562698 A JP2023562698 A JP 2023562698A JP 2023562698 A JP2023562698 A JP 2023562698A JP 2024513972 A JP2024513972 A JP 2024513972A
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nucleic acid
nucleotide
acid according
antisense strand
target
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JP2024513972A5 (enExample
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ジェン リー，
ジーチン ジョウ，
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エーダーエックス ファーマシューティカルズ， インコーポレイテッド
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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JP2023562698A 2021-04-13 2022-04-13 Ｒｎａサイレンシング剤および使用方法 Pending JP2024513972A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163174507P 2021-04-13 2021-04-13
US63/174,507 2021-04-13
PCT/US2022/024692 WO2022221457A1 (en) 2021-04-13 2022-04-13 Rna silencing agents and methods of use

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JP2024513972A true JP2024513972A (ja) 2024-03-27
JP2024513972A5 JP2024513972A5 (enExample) 2025-04-09

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US (1) US20240191229A1 (enExample)
EP (1) EP4323376A4 (enExample)
JP (1) JP2024513972A (enExample)
CN (1) CN117425664A (enExample)
AU (1) AU2022257002A1 (enExample)
CA (1) CA3216732A1 (enExample)
WO (1) WO2022221457A1 (enExample)

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US11597744B2 (en) 2017-06-30 2023-03-07 Sirius Therapeutics, Inc. Chiral phosphoramidite auxiliaries and methods of their use
US20240401045A1 (en) * 2021-10-01 2024-12-05 Adarx Pharmaceuticals, Inc. Angiotensinogen-modulating compositions and methods of use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012512651A (ja) * 2008-12-18 2012-06-07 ダイセルナ ファーマシューティカルズ， インコーポレイテッド 遺伝子発現の特異的阻害のための拡張ｄｉｃｅｒ基質薬剤および方法
JP2013535982A (ja) * 2010-08-24 2013-09-19 メルク・シャープ・エンド・ドーム・コーポレイション 内部非核酸スペーサーを含む一本鎖ＲＮＡｉ剤関連出願の相互参照本出願は、２０１０年８月２４日に出願された米国特許仮出願第６１／３７６，４７１号の恩典を主張し、該仮出願は引用により本明細書に組み込まれる。
WO2016011123A1 (en) * 2014-07-16 2016-01-21 Arrowhead Research Corporation Organic compositions to treat apoc3-related diseases
JP2017537618A (ja) * 2014-12-17 2017-12-21 プロキューアール・セラピューティクス・セカンド・ベスローテン・フェンノートシャップＰｒｏＱＲ Ｔｈｅｒａｐｅｕｔｉｃｓ ＩＩ Ｂ．Ｖ． 標的化ｒｎａ編集

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8188060B2 (en) * 2008-02-11 2012-05-29 Dharmacon, Inc. Duplex oligonucleotides with enhanced functionality in gene regulation
EP2264169A1 (en) * 2009-06-15 2010-12-22 Qiagen GmbH Modified siNA
KR101696704B1 (ko) * 2013-12-17 2017-01-16 주식회사 인코드젠 오프-타겟을 막기 위해 변형된 rna 간섭 유도 핵산 및 그 용도

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012512651A (ja) * 2008-12-18 2012-06-07 ダイセルナ ファーマシューティカルズ， インコーポレイテッド 遺伝子発現の特異的阻害のための拡張ｄｉｃｅｒ基質薬剤および方法
JP2013535982A (ja) * 2010-08-24 2013-09-19 メルク・シャープ・エンド・ドーム・コーポレイション 内部非核酸スペーサーを含む一本鎖ＲＮＡｉ剤関連出願の相互参照本出願は、２０１０年８月２４日に出願された米国特許仮出願第６１／３７６，４７１号の恩典を主張し、該仮出願は引用により本明細書に組み込まれる。
WO2016011123A1 (en) * 2014-07-16 2016-01-21 Arrowhead Research Corporation Organic compositions to treat apoc3-related diseases
JP2017537618A (ja) * 2014-12-17 2017-12-21 プロキューアール・セラピューティクス・セカンド・ベスローテン・フェンノートシャップＰｒｏＱＲ Ｔｈｅｒａｐｅｕｔｉｃｓ ＩＩ Ｂ．Ｖ． 標的化ｒｎａ編集

Non-Patent Citations (4)

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Title
HUANG HUANG ET AL, NUCLEIC ACIDS RESEARCH, vol. 37, no. 22, JPN7026001114, 2009, pages 7560 - 7569, ISSN: 0005818139 *
NA WEI ET AL, PLOS ONE, vol. Vol. 7, Issue 11, Article number e49309, JPN7026001115, 2012, ISSN: 0005818140 *
QUAN DU ET AL, NUCLEIC ACIDS RESEARCH, vol. 33, no. 5, JPN7026001113, 2005, pages 1671 - 1677, ISSN: 0005818138 *
TOBY PASSIOURA ET AL, BMC BIOTECHNOLOGY, vol. Vol. 9, Article number 57, JPN7026001116, 2009, ISSN: 0005818141 *

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CN117425664A (zh) 2024-01-19
US20240191229A1 (en) 2024-06-13
CA3216732A1 (en) 2022-10-20
EP4323376A4 (en) 2025-07-09
WO2022221457A1 (en) 2022-10-20
AU2022257002A1 (en) 2023-10-26
EP4323376A1 (en) 2024-02-21

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