JP2024511414A - 腫瘍浸潤リンパ球のｃｉｓｈ遺伝子編集及び免疫療法におけるその使用 - Google Patents

腫瘍浸潤リンパ球のｃｉｓｈ遺伝子編集及び免疫療法におけるその使用 Download PDF

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JP2024511414A
JP2024511414A JP2023558138A JP2023558138A JP2024511414A JP 2024511414 A JP2024511414 A JP 2024511414A JP 2023558138 A JP2023558138 A JP 2023558138A JP 2023558138 A JP2023558138 A JP 2023558138A JP 2024511414 A JP2024511414 A JP 2024511414A
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til
tale
cish
expansion
nuclease
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JP2024511414A5 (enExample
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リッチピチャイ，クリット
ジュリーラット，アレクサンドル
ボイン，アレックス
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アイオバンス バイオセラピューティクス，インコーポレイテッド
セレクティス ソシエテ アノニム
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
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    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N5/0602—Vertebrate cells
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2510/00—Genetically modified cells

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2023558138A 2021-03-23 2022-03-22 腫瘍浸潤リンパ球のｃｉｓｈ遺伝子編集及び免疫療法におけるその使用 Pending JP2024511414A (ja)

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US202163165066P 2021-03-23 2021-03-23
US63/165,066 2021-03-23
PCT/US2022/021356 WO2022204155A1 (en) 2021-03-23 2022-03-22 Cish gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy

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JP2024511414A true JP2024511414A (ja) 2024-03-13
JP2024511414A5 JP2024511414A5 (enExample) 2025-03-27

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US (1) US20250345364A1 (enExample)
EP (1) EP4313122A1 (enExample)
JP (1) JP2024511414A (enExample)
CN (1) CN118019546A (enExample)
AR (1) AR125199A1 (enExample)
CA (1) CA3213080A1 (enExample)
TW (1) TW202305118A (enExample)
WO (1) WO2022204155A1 (enExample)

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GB201700621D0 (en) 2017-01-13 2017-03-01 Guest Ryan Dominic Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
WO2023039488A1 (en) * 2021-09-09 2023-03-16 Iovance Biotherapeutics, Inc. Processes for generating til products using pd-1 talen knockdown
CN119579620B (zh) * 2024-12-03 2026-04-24 郑州大学 一种胶质母细胞瘤瘤周肿瘤浸润分割模型构建方法

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WO2019210131A1 (en) * 2018-04-27 2019-10-31 Iovance Biotherapeutics, Inc. Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
JP2019532080A (ja) * 2016-10-18 2019-11-07 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 腫瘍浸潤リンパ球および治療の方法

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