JP2024511165A - バンコマイシンと組み合わせたリファマイシン類似体およびその使用 - Google Patents

バンコマイシンと組み合わせたリファマイシン類似体およびその使用 Download PDF

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Publication number
JP2024511165A
JP2024511165A JP2023558774A JP2023558774A JP2024511165A JP 2024511165 A JP2024511165 A JP 2024511165A JP 2023558774 A JP2023558774 A JP 2023558774A JP 2023558774 A JP2023558774 A JP 2023558774A JP 2024511165 A JP2024511165 A JP 2024511165A
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JP
Japan
Prior art keywords
pharmaceutically acceptable
acceptable salt
vancomycin
compound
derivative
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Pending
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JP2023558774A
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English (en)
Japanese (ja)
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JP2024511165A5 (https=
Inventor
ニットーリ，トーマス
ツムシュテーク，アンナ
Original Assignee
リジェネロン ファーマシューティカルズ，インク．
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Application filed by リジェネロン ファーマシューティカルズ，インク． filed Critical リジェネロン ファーマシューティカルズ，インク．
Publication of JP2024511165A publication Critical patent/JP2024511165A/ja
Publication of JP2024511165A5 publication Critical patent/JP2024511165A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2023558774A 2021-03-26 2022-03-25 バンコマイシンと組み合わせたリファマイシン類似体およびその使用 Pending JP2024511165A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163166597P 2021-03-26 2021-03-26
US63/166,597 2021-03-26
PCT/US2022/021922 WO2022204499A1 (en) 2021-03-26 2022-03-25 Rifamycin analogs in combination with vancomycin and uses thereof

Publications (2)

Publication Number Publication Date
JP2024511165A true JP2024511165A (ja) 2024-03-12
JP2024511165A5 JP2024511165A5 (https=) 2025-02-25

Family

ID=81308077

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023558774A Pending JP2024511165A (ja) 2021-03-26 2022-03-25 バンコマイシンと組み合わせたリファマイシン類似体およびその使用

Country Status (14)

Country Link
US (1) US20240189319A1 (https=)
EP (1) EP4313060B1 (https=)
JP (1) JP2024511165A (https=)
KR (1) KR20230162654A (https=)
CN (1) CN117098540A (https=)
AU (1) AU2022246161A1 (https=)
BR (1) BR112023019720A2 (https=)
CA (1) CA3213382A1 (https=)
CL (1) CL2023002840A1 (https=)
CO (1) CO2023013406A2 (https=)
ES (1) ES3017798T3 (https=)
IL (1) IL307220A (https=)
MX (1) MX2023011328A (https=)
WO (1) WO2022204499A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024221162A1 (zh) * 2023-04-24 2024-10-31 丹诺医药(苏州）有限公司 化合物预防关节假体周围感染的方法
KR20260012505A (ko) 2024-07-18 2026-01-27 이화여자대학교 산학협력단 기계 학습을 이용한 반코마이신 초회 투여량 적합성 판단 시스템 및 방법

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019217591A1 (en) * 2018-05-09 2019-11-14 Regeneron Pharmaceuticals, Inc. Anti-msr1 antibodies and methods of use thereof
WO2020132483A1 (en) * 2018-12-21 2020-06-25 Regeneron Pharmaceuticals, Inc. Rifamycin analogs and antibody-drug conjugates thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019217591A1 (en) * 2018-05-09 2019-11-14 Regeneron Pharmaceuticals, Inc. Anti-msr1 antibodies and methods of use thereof
WO2020132483A1 (en) * 2018-12-21 2020-06-25 Regeneron Pharmaceuticals, Inc. Rifamycin analogs and antibody-drug conjugates thereof

Also Published As

Publication number Publication date
US20240189319A1 (en) 2024-06-13
CN117098540A (zh) 2023-11-21
BR112023019720A2 (pt) 2024-01-23
CO2023013406A2 (es) 2023-10-30
AU2022246161A1 (en) 2023-10-12
KR20230162654A (ko) 2023-11-28
ES3017798T3 (en) 2025-05-13
CA3213382A1 (en) 2022-09-29
WO2022204499A1 (en) 2022-09-29
MX2023011328A (es) 2023-12-14
CL2023002840A1 (es) 2024-03-15
EP4313060A1 (en) 2024-02-07
IL307220A (en) 2023-11-01
EP4313060B1 (en) 2025-03-05

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