JP2024511137A - Ｃｄ４７およびｐｄ－ｌ１を標的とする二重特異性抗体ならびにその使用方法 - Google Patents

Ｃｄ４７およびｐｄ－ｌ１を標的とする二重特異性抗体ならびにその使用方法 Download PDF

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JP2024511137A
JP2024511137A JP2023558578A JP2023558578A JP2024511137A JP 2024511137 A JP2024511137 A JP 2024511137A JP 2023558578 A JP2023558578 A JP 2023558578A JP 2023558578 A JP2023558578 A JP 2023558578A JP 2024511137 A JP2024511137 A JP 2024511137A
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seq
acid sequence
amino acid
cdrl1
cdrl2
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JP2024511137A5 (https=
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グザヴィエ ショーシェ
クシシュトフ マステルナク
リミン シャン
ジョヴァンニ マジストレッリ
ニコラス フィッシャー
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ノビミューン エスアー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2023558578A 2021-03-22 2022-03-22 Ｃｄ４７およびｐｄ－ｌ１を標的とする二重特異性抗体ならびにその使用方法 Pending JP2024511137A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163164329P 2021-03-22 2021-03-22
US63/164,329 2021-03-22
US202263317899P 2022-03-08 2022-03-08
US63/317,899 2022-03-08
PCT/EP2022/057555 WO2022200389A1 (en) 2021-03-22 2022-03-22 Bispecific antibodies targeting cd47 and pd-l1 and methods of use thereof

Publications (2)

Publication Number Publication Date
JP2024511137A true JP2024511137A (ja) 2024-03-12
JP2024511137A5 JP2024511137A5 (https=) 2025-03-31

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JP2023558578A Pending JP2024511137A (ja) 2021-03-22 2022-03-22 Ｃｄ４７およびｐｄ－ｌ１を標的とする二重特異性抗体ならびにその使用方法

Country Status (7)

Country Link
US (1) US12448444B2 (https=)
EP (1) EP4314065A1 (https=)
JP (1) JP2024511137A (https=)
AU (1) AU2022245196A1 (https=)
CA (1) CA3212056A1 (https=)
IL (1) IL305827A (https=)
WO (1) WO2022200389A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
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US12448444B2 (en) 2021-03-22 2025-10-21 Novimmune Sa Bispecific antibodies targeting CD47 and PD-L1 and methods of use thereof
IL305828A (en) * 2021-03-22 2023-11-01 Novimmune Sa Bispecific antibodies targeting CD47 and PD-L1 and methods of using them
EP4493592A1 (en) 2022-03-14 2025-01-22 LamKap Bio gamma AG Bispecific gpc3xcd28 and gpc3xcd3 antibodies and their combination for targeted killing of gpc3 positive malignant cells
US20240254223A1 (en) * 2022-09-02 2024-08-01 Novimmune Sa Reciprocally masked antibody-cytokine fusion proteins and methods of use thereof
US20240254234A1 (en) 2022-10-21 2024-08-01 Novimmune Sa PD-L1xCD28 BISPECIFIC ANTIBODIES FOR IMMUNE CHECKPOINT-DEPENDENT T CELL ACTIVATION
WO2025133389A1 (en) * 2023-12-22 2025-06-26 Numab Therapeutics AG Antibody binding domains having specificity for lilrb2
EP4574844A1 (en) * 2023-12-22 2025-06-25 Numab Therapeutics AG Multispecific antibodies having specificity for cd47 and pdl1

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WO2018215835A1 (en) * 2017-05-26 2018-11-29 Novimmune Sa Anti-cd47 x anti-mesothelin antibodies and methods of use thereof
WO2019016411A1 (en) * 2017-07-21 2019-01-24 Novimmune Sa GENERATION OF MULTISPECIFIC ANTIBODY MIXTURES AND METHODS OF USE
JP2021505195A (ja) * 2017-12-04 2021-02-18 北京韓美薬品有限公司Ｂｅｉｊｉｎｇ Ｈａｎｍｉ Ｐｈａｒｍ． Ｃｏ．， Ｌｔｄ． 天然抗体様構造を有し、ヘテロ二量体形態の抗ｐｄ−ｌ１／抗ｃｄ４７二重特異性抗体、ならびにその製造方法

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WO2018215835A1 (en) * 2017-05-26 2018-11-29 Novimmune Sa Anti-cd47 x anti-mesothelin antibodies and methods of use thereof
WO2019016411A1 (en) * 2017-07-21 2019-01-24 Novimmune Sa GENERATION OF MULTISPECIFIC ANTIBODY MIXTURES AND METHODS OF USE
JP2021505195A (ja) * 2017-12-04 2021-02-18 北京韓美薬品有限公司Ｂｅｉｊｉｎｇ Ｈａｎｍｉ Ｐｈａｒｍ． Ｃｏ．， Ｌｔｄ． 天然抗体様構造を有し、ヘテロ二量体形態の抗ｐｄ−ｌ１／抗ｃｄ４７二重特異性抗体、ならびにその製造方法

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EP4314065A1 (en) 2024-02-07
WO2022200389A1 (en) 2022-09-29
US20220315655A1 (en) 2022-10-06
US12448444B2 (en) 2025-10-21
AU2022245196A1 (en) 2023-09-21
IL305827A (en) 2023-11-01
CA3212056A1 (en) 2022-09-29

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