JP2024509501A - 新規活性を持つｈｈｌａ２結合剤 - Google Patents

新規活性を持つｈｈｌａ２結合剤 Download PDF

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Publication number
JP2024509501A
JP2024509501A JP2023544261A JP2023544261A JP2024509501A JP 2024509501 A JP2024509501 A JP 2024509501A JP 2023544261 A JP2023544261 A JP 2023544261A JP 2023544261 A JP2023544261 A JP 2023544261A JP 2024509501 A JP2024509501 A JP 2024509501A
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JP
Japan
Prior art keywords
hhla2
binding
antibody
antigen
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023544261A
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English (en)
Japanese (ja)
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JP2024509501A5 (https=
JPWO2022165258A5 (https=
Inventor
スコット チャッペル，
デトレフ ビニスキーウィチ，
ビジャン エテマド－ギルバートソン，
ナドタカーン ボーランド，
ネルス ニールソン，
ビアンカ プリンツ，
Original Assignee
ネクストポイント セラピューティクス， インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by ネクストポイント セラピューティクス， インコーポレイテッド filed Critical ネクストポイント セラピューティクス， インコーポレイテッド
Publication of JP2024509501A publication Critical patent/JP2024509501A/ja
Publication of JP2024509501A5 publication Critical patent/JP2024509501A5/ja
Publication of JPWO2022165258A5 publication Critical patent/JPWO2022165258A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Catalysts (AREA)
JP2023544261A 2021-01-28 2022-01-28 新規活性を持つｈｈｌａ２結合剤 Pending JP2024509501A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163142832P 2021-01-28 2021-01-28
US63/142,832 2021-01-28
PCT/US2022/014423 WO2022165258A1 (en) 2021-01-28 2022-01-28 Hhla2 binding agents with novel activity

Publications (3)

Publication Number Publication Date
JP2024509501A true JP2024509501A (ja) 2024-03-04
JP2024509501A5 JP2024509501A5 (https=) 2025-02-04
JPWO2022165258A5 JPWO2022165258A5 (https=) 2025-02-04

Family

ID=82652818

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023544261A Pending JP2024509501A (ja) 2021-01-28 2022-01-28 新規活性を持つｈｈｌａ２結合剤

Country Status (11)

Country Link
US (1) US20250270323A1 (https=)
EP (1) EP4284431A4 (https=)
JP (1) JP2024509501A (https=)
KR (1) KR20230135637A (https=)
CN (1) CN116981476A (https=)
AU (1) AU2022214939A1 (https=)
BR (1) BR112023014826A2 (https=)
CA (1) CA3207494A1 (https=)
IL (1) IL304584A (https=)
MX (1) MX2023008182A (https=)
WO (1) WO2022165258A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL326764A (en) * 2023-09-08 2026-04-01 Nextpoint Therapeutics Inc Antibody-drug conjugates
CN119841949A (zh) * 2023-10-17 2025-04-18 科辉智药(深圳)新药研究中心有限公司 一种抗人hhla2的纳米抗体及其应用
CN121005781A (zh) * 2024-05-24 2025-11-25 合肥天港免疫药物有限公司 高亲和力b7h7抗体或其抗原结合片段及其用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019204057A1 (en) * 2018-04-06 2019-10-24 Dana-Farber Cancer Institute, Inc. Kir3dl3 as an hhla2 receptor, anti-hhla2 antibodies, and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10280208B2 (en) * 2014-04-30 2019-05-07 Albert Einstein College Of Medicine TMIGD2 and its derivatives as blockers or binders of cancer-expressed HHLA2 for immunotherapies
EA202090003A1 (ru) * 2017-07-06 2020-06-18 Мерус Н.В. Связывающие молекулы, модулирующие биологическую активность, которую проявляет клетка

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019204057A1 (en) * 2018-04-06 2019-10-24 Dana-Farber Cancer Institute, Inc. Kir3dl3 as an hhla2 receptor, anti-hhla2 antibodies, and uses thereof

Also Published As

Publication number Publication date
KR20230135637A (ko) 2023-09-25
EP4284431A4 (en) 2025-01-15
BR112023014826A2 (pt) 2023-10-03
AU2022214939A1 (en) 2023-07-20
CN116981476A (zh) 2023-10-31
US20250270323A1 (en) 2025-08-28
IL304584A (en) 2023-09-01
MX2023008182A (es) 2023-09-15
WO2022165258A1 (en) 2022-08-04
EP4284431A1 (en) 2023-12-06
CA3207494A1 (en) 2022-08-04

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