CN116981476A - 具有新型活性的hhla2结合剂 - Google Patents

具有新型活性的hhla2结合剂 Download PDF

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Publication number
CN116981476A
CN116981476A CN202280012137.1A CN202280012137A CN116981476A CN 116981476 A CN116981476 A CN 116981476A CN 202280012137 A CN202280012137 A CN 202280012137A CN 116981476 A CN116981476 A CN 116981476A
Authority
CN
China
Prior art keywords
hhla2
antibody
binding agent
amino acid
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202280012137.1A
Other languages
English (en)
Chinese (zh)
Inventor
S·查佩尔
D·比尼斯凯维奇
B·埃特马德吉尔博特逊
N·伯兰德
N·尼尔森
B·普林茨
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nextpoint Treatment Co
Original Assignee
Nextpoint Treatment Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nextpoint Treatment Co filed Critical Nextpoint Treatment Co
Publication of CN116981476A publication Critical patent/CN116981476A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Catalysts (AREA)
CN202280012137.1A 2021-01-28 2022-01-28 具有新型活性的hhla2结合剂 Pending CN116981476A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163142832P 2021-01-28 2021-01-28
US63/142,832 2021-01-28
PCT/US2022/014423 WO2022165258A1 (en) 2021-01-28 2022-01-28 Hhla2 binding agents with novel activity

Publications (1)

Publication Number Publication Date
CN116981476A true CN116981476A (zh) 2023-10-31

Family

ID=82652818

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280012137.1A Pending CN116981476A (zh) 2021-01-28 2022-01-28 具有新型活性的hhla2结合剂

Country Status (11)

Country Link
US (1) US20250270323A1 (https=)
EP (1) EP4284431A4 (https=)
JP (1) JP2024509501A (https=)
KR (1) KR20230135637A (https=)
CN (1) CN116981476A (https=)
AU (1) AU2022214939A1 (https=)
BR (1) BR112023014826A2 (https=)
CA (1) CA3207494A1 (https=)
IL (1) IL304584A (https=)
MX (1) MX2023008182A (https=)
WO (1) WO2022165258A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025241703A1 (zh) * 2024-05-24 2025-11-27 合肥天港免疫药物有限公司 高亲和力b7h7抗体或其抗原结合片段及其用途

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL326764A (en) * 2023-09-08 2026-04-01 Nextpoint Therapeutics Inc Antibody-drug conjugates
CN119841949A (zh) * 2023-10-17 2025-04-18 科辉智药(深圳)新药研究中心有限公司 一种抗人hhla2的纳米抗体及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10280208B2 (en) * 2014-04-30 2019-05-07 Albert Einstein College Of Medicine TMIGD2 and its derivatives as blockers or binders of cancer-expressed HHLA2 for immunotherapies
EA202090003A1 (ru) * 2017-07-06 2020-06-18 Мерус Н.В. Связывающие молекулы, модулирующие биологическую активность, которую проявляет клетка
KR20210007959A (ko) * 2018-04-06 2021-01-20 다나-파버 캔서 인스티튜트 인크. Hhla2 수용체로서의 kir3dl3, 항-hhla2 항체, 및 이들의 용도

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025241703A1 (zh) * 2024-05-24 2025-11-27 合肥天港免疫药物有限公司 高亲和力b7h7抗体或其抗原结合片段及其用途

Also Published As

Publication number Publication date
KR20230135637A (ko) 2023-09-25
EP4284431A4 (en) 2025-01-15
BR112023014826A2 (pt) 2023-10-03
JP2024509501A (ja) 2024-03-04
AU2022214939A1 (en) 2023-07-20
US20250270323A1 (en) 2025-08-28
IL304584A (en) 2023-09-01
MX2023008182A (es) 2023-09-15
WO2022165258A1 (en) 2022-08-04
EP4284431A1 (en) 2023-12-06
CA3207494A1 (en) 2022-08-04

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