JP2024507929A5 - - Google Patents
Info
- Publication number
- JP2024507929A5 JP2024507929A5 JP2023551669A JP2023551669A JP2024507929A5 JP 2024507929 A5 JP2024507929 A5 JP 2024507929A5 JP 2023551669 A JP2023551669 A JP 2023551669A JP 2023551669 A JP2023551669 A JP 2023551669A JP 2024507929 A5 JP2024507929 A5 JP 2024507929A5
- Authority
- JP
- Japan
- Prior art keywords
- polynucleotide sequence
- amino acid
- seq
- acid sequence
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163153862P | 2021-02-25 | 2021-02-25 | |
| US63/153,862 | 2021-02-25 | ||
| US202163159434P | 2021-03-10 | 2021-03-10 | |
| US63/159,434 | 2021-03-10 | ||
| US202163260409P | 2021-08-19 | 2021-08-19 | |
| US63/260,409 | 2021-08-19 | ||
| US202163260855P | 2021-09-02 | 2021-09-02 | |
| US63/260,855 | 2021-09-02 | ||
| US202263267421P | 2022-02-01 | 2022-02-01 | |
| US63/267,421 | 2022-02-01 | ||
| PCT/US2022/070690 WO2022183167A1 (en) | 2021-02-25 | 2022-02-17 | Recombinant vectors comprising polycistronic expression cassettes and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024507929A JP2024507929A (ja) | 2024-02-21 |
| JP2024507929A5 true JP2024507929A5 (https=) | 2025-02-25 |
Family
ID=80628943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023551669A Pending JP2024507929A (ja) | 2021-02-25 | 2022-02-17 | 多シストロン性発現カセットを含む組換えベクター及びそれらの使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20240175047A1 (https=) |
| EP (1) | EP4298121A1 (https=) |
| JP (1) | JP2024507929A (https=) |
| KR (1) | KR20230150336A (https=) |
| AU (1) | AU2022227085A1 (https=) |
| CA (1) | CA3209732A1 (https=) |
| IL (1) | IL305393A (https=) |
| WO (1) | WO2022183167A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4110804A1 (en) * | 2020-02-26 | 2023-01-04 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Hla class ii-restricted t cell receptors against ras with g12v mutation |
| US20250145950A1 (en) * | 2022-02-01 | 2025-05-08 | Alaunos Therapeutics, Inc. | Methods for Activation and Expansion of T Cells |
| US20250216381A1 (en) | 2022-03-21 | 2025-07-03 | Alaunos Therapeutics, Inc. | Methods for Identifying Neoantigen-Reactive T Cell Receptors |
| WO2024059621A2 (en) * | 2022-09-13 | 2024-03-21 | The Trustees Of The University Of Pennsylvania | T-cell receptors and compositions thereof for targeting mutant ras |
| WO2024163371A1 (en) * | 2023-01-30 | 2024-08-08 | Fred Hutchinson Cancer Center | Binding proteins specific for mutant p53 and uses thereof |
| WO2024197072A2 (en) | 2023-03-21 | 2024-09-26 | Alaunos Therapeutics, Inc. | Identification of neoantigen-reactive t cell receptors |
| WO2024206274A2 (en) * | 2023-03-27 | 2024-10-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T cell receptors targeting y220c or r175h mutation in p53 |
| CN117143823B (zh) * | 2023-09-11 | 2024-07-16 | 皖南医学院第一附属医院（皖南医学院弋矶山医院） | 一种基于tcr单链可变区的靶向ras(g12v)的嵌合抗原受体记忆nk细胞的研制及其应用 |
| WO2025056681A1 (en) * | 2023-09-15 | 2025-03-20 | Medigene Immunotherapies Gmbh | T-CELL RECEPTOR AGAINST mKRAS7-16 G12V AND G12C |
| WO2025096983A1 (en) * | 2023-11-02 | 2025-05-08 | Board Of Regents, The University Of Texas System | Peptides and engineered t cell receptors targeting tpx2 antigen and methods of use |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996018105A1 (en) | 1994-12-06 | 1996-06-13 | The President And Fellows Of Harvard College | Single chain t-cell receptor |
| ATE466948T1 (de) | 1997-03-11 | 2010-05-15 | Univ Minnesota | Dns-basiertes transposon-system für die einführung von nucleinsäure in die dns einer zelle |
| GB9809658D0 (en) | 1998-05-06 | 1998-07-01 | Celltech Therapeutics Ltd | Biological products |
| IL127142A0 (en) | 1998-11-19 | 1999-09-22 | Yeda Res & Dev | Immune cells having predefined biological specificity |
| WO2000063374A1 (en) | 1999-04-16 | 2000-10-26 | Celltech Therapeutics Limited | Synthetic transmembrane components |
| IL160359A0 (en) | 2001-08-31 | 2004-07-25 | Avidex Ltd | Soluble t cell receptor |
| US20040014194A1 (en) | 2002-03-27 | 2004-01-22 | Schering Corporation | Beta-secretase crystals and methods for preparing and using the same |
| WO2003089618A2 (en) | 2002-04-22 | 2003-10-30 | Regents Of The University Of Minnesota | Transposon system and methods of use |
| CA2501870C (en) | 2002-10-09 | 2013-07-02 | Avidex Limited | Single chain recombinant t cell receptors |
| ATE475669T1 (de) | 2004-06-29 | 2010-08-15 | Immunocore Ltd | Einen modifizierten t-zellen-rezeptor exprimierende zellen |
| GB0712670D0 (en) | 2007-06-29 | 2007-08-08 | King S College London | Isolated peptides and uses thereof |
| EP2160461B1 (en) | 2007-07-04 | 2012-08-08 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Hyperactive variants of the transposase protein of the transposon system sleeping beauty |
| EP2486049A1 (en) | 2009-10-06 | 2012-08-15 | The Board Of Trustees Of The UniversityOf Illinois | Human single-chain t cell receptors |
| CA3285826A1 (en) | 2012-02-22 | 2026-03-02 | The Trustees Of The University Of Pennsylvania | Compositions and methods for generating a persisting population of t cells useful for the treatment of cancer |
| PT2692865E (pt) | 2012-07-30 | 2015-02-06 | Nbe Therapeutics Llc | Identificação mediada por transposição de proteínas funcionais ou de ligação específicas |
| CN118994363A (zh) | 2014-11-26 | 2024-11-22 | 美国卫生和人力服务部 | 抗突变的kras的t细胞受体 |
| KR102615825B1 (ko) | 2015-03-11 | 2023-12-21 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 전위효소 폴리펩타이드 및 이의 용도 |
| ES2879287T3 (es) | 2015-09-15 | 2021-11-22 | Us Health | Receptores de células T que reconocen KRAS mutado restringido a HLA-cw8 |
| HRP20221183T1 (hr) | 2016-08-02 | 2022-12-09 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | T-stanični receptori anti-kras-g12d |
| KR20200003913A (ko) | 2017-05-10 | 2020-01-10 | 이오반스 바이오테라퓨틱스, 인크. | 액상 종양으로부터의 종양 침윤 림프구의 확장 및 그의 치료 용도 |
| CA3065930A1 (en) * | 2017-06-07 | 2018-12-13 | Intrexon Corporation | Expression of novel cell tags |
| EP3673053A1 (en) | 2017-08-21 | 2020-07-01 | EMBL European Molecular Biology Laboratory | Improved transposase polypeptide and uses thereof |
| KR20250037592A (ko) | 2017-09-20 | 2025-03-17 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | 돌연변이된 ras에 대한 hla 클래스 ii-제한된 t 세포 수용체 |
| SG11202002635RA (en) | 2017-09-29 | 2020-04-29 | The United States Of America As Represented By The Secretary | Methods of isolating t cells having antigenic specificity for a p53 cancer-specific mutation |
| WO2019067243A1 (en) | 2017-09-29 | 2019-04-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T CELL RECEPTORS RECOGNIZING P53 MUTE |
| AU2018345400B2 (en) | 2017-10-05 | 2024-06-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods for selectively expanding cells expressing a TCR with a murine constant region |
| CR20200287A (es) | 2017-12-04 | 2020-11-11 | Us Health | Receptores de células t restringidos a antígeno leucocitario humano (hla) clase i contra sarcoma de rata (ras) mutado |
| US20200399383A1 (en) * | 2018-02-13 | 2020-12-24 | Novartis Ag | Chimeric antigen receptor therapy in combination with il-15r and il15 |
| EP3561053A1 (en) * | 2018-04-26 | 2019-10-30 | Baylor College of Medicine | Immune effector cells and molecular adaptors with an antigen cytokine complex for effective cancer immunotherapy |
| WO2019213195A1 (en) | 2018-05-01 | 2019-11-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T cell receptors which recognize mutated egfr |
| CA3116749A1 (en) | 2018-10-24 | 2020-04-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Hla-a3-restricted t cell receptors against mutated ras |
| EP3883955A1 (en) * | 2018-11-19 | 2021-09-29 | Board of Regents, The University of Texas System | A modular, polycistronic vector for car and tcr transduction |
| EP3914612A1 (en) | 2019-01-22 | 2021-12-01 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Hla class ii-restricted t cell receptors against ras with g12r mutation |
| TW202525841A (zh) | 2019-06-27 | 2025-07-01 | 美國衛生與公眾服務部 | 識別p53中之r175h或y220c突變之t細胞受體 |
| CN115279784A (zh) | 2020-02-12 | 2022-11-01 | 美国卫生和人力服务部 | 针对含有g12d突变的ras的hla i类限制性t细胞受体 |
| KR20220143875A (ko) | 2020-02-14 | 2022-10-25 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | G12v 돌연변이를 갖는 ras에 대한 hla 클래스 i-제한된 t 세포 수용체 |
| EP4110804A1 (en) | 2020-02-26 | 2023-01-04 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Hla class ii-restricted t cell receptors against ras with g12v mutation |
-
2022
- 2022-02-17 WO PCT/US2022/070690 patent/WO2022183167A1/en not_active Ceased
- 2022-02-17 JP JP2023551669A patent/JP2024507929A/ja active Pending
- 2022-02-17 KR KR1020237032793A patent/KR20230150336A/ko active Pending
- 2022-02-17 EP EP22708022.3A patent/EP4298121A1/en not_active Withdrawn
- 2022-02-17 IL IL305393A patent/IL305393A/en unknown
- 2022-02-17 CA CA3209732A patent/CA3209732A1/en active Pending
- 2022-02-17 US US18/547,827 patent/US20240175047A1/en active Pending
- 2022-02-17 AU AU2022227085A patent/AU2022227085A1/en not_active Abandoned
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