JP2024505151A5 - - Google Patents
Info
- Publication number
- JP2024505151A5 JP2024505151A5 JP2023541965A JP2023541965A JP2024505151A5 JP 2024505151 A5 JP2024505151 A5 JP 2024505151A5 JP 2023541965 A JP2023541965 A JP 2023541965A JP 2023541965 A JP2023541965 A JP 2023541965A JP 2024505151 A5 JP2024505151 A5 JP 2024505151A5
- Authority
- JP
- Japan
- Prior art keywords
- lnp
- oligonucleotide
- sna
- toll
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163136501P | 2021-01-12 | 2021-01-12 | |
| US63/136,501 | 2021-01-12 | ||
| PCT/US2022/012023 WO2022155149A1 (en) | 2021-01-12 | 2022-01-11 | Lipid nanoparticle spherical nucleic acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024505151A JP2024505151A (ja) | 2024-02-05 |
| JP2024505151A5 true JP2024505151A5 (https=) | 2025-01-21 |
Family
ID=82447506
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023541965A Pending JP2024505151A (ja) | 2021-01-12 | 2022-01-11 | 脂質ナノ粒子球状核酸 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20240309367A1 (https=) |
| EP (1) | EP4277590A4 (https=) |
| JP (1) | JP2024505151A (https=) |
| CN (1) | CN116940324A (https=) |
| WO (1) | WO2022155149A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12378560B2 (en) | 2019-10-29 | 2025-08-05 | Northwestern University | Sequence multiplicity within spherical nucleic acids |
| KR20250112318A (ko) * | 2022-10-27 | 2025-07-23 | 씨울프 테라퓨틱스, 인코포레이티드 | 핵 표적 dna 전달 및 이를 실시하는데 사용하기 위한 조성물 |
| EP4630061A1 (en) * | 2022-12-08 | 2025-10-15 | Nanovation Therapeutics Inc. | Lipid nanoparticles comprising elevated neutral lipid and a targeting moiety for targeted delivery of nucleic acid |
| WO2026006618A1 (en) * | 2024-06-26 | 2026-01-02 | Northwestern University | Lipid nanoparticle spherical nucleic acids for genome engineering |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7404969B2 (en) * | 2005-02-14 | 2008-07-29 | Sirna Therapeutics, Inc. | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules |
| IT1397011B1 (it) * | 2009-10-14 | 2012-12-20 | Univ Ferrara | Nanoparticella del tipo core-shell idonea per la veicolazione di oligonucleotidi terapeutici in tessuti bersaglio e suo impiego per la preparazione di un medicamento per il trattamento della distrofia muscolare di duchenne. |
| EP2860255A1 (en) * | 2013-10-14 | 2015-04-15 | Technische Universität Graz | Compositions comprising cationic and neutral lipids for transfecting nucleic acid molecules into eukaryotic cells |
| EP3470089A1 (en) * | 2013-12-12 | 2019-04-17 | The Broad Institute Inc. | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components |
| WO2017011662A1 (en) * | 2015-07-14 | 2017-01-19 | Exicure, Inc. | Spherical nucleic acid (sna)-mediated delivery of lipid-complexes to cells |
| WO2018067302A2 (en) * | 2016-09-19 | 2018-04-12 | North Western University | Therapeutic effects of cellular delivery of small molecules and macromolecules with liposomal spherical nucleic acids |
| US11583504B2 (en) * | 2016-11-08 | 2023-02-21 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| US20200248183A1 (en) * | 2017-04-03 | 2020-08-06 | Subbarao Nallagatla | Tlr9-targeted spherical nucleic acids having potent antitumor activity |
| MA49421A (fr) * | 2017-06-15 | 2020-04-22 | Modernatx Inc | Formulations d'arn |
| MX2020000387A (es) * | 2017-07-13 | 2020-08-17 | Univ Northwestern | Método general y directo para preparar nanopartículas de estructura organometálica funcionalizadas con oligonucleotidos. |
| WO2019118883A1 (en) * | 2017-12-15 | 2019-06-20 | Northwestern University | Structure-function relationships in the development of immunotherapeutic agents |
| US20190314291A1 (en) * | 2018-01-30 | 2019-10-17 | Modernatx, Inc. | Compositions and methods for delivery of agents to immune cells |
| WO2020168005A1 (en) * | 2019-02-12 | 2020-08-20 | Exicure, Inc. | Combined spherical nucleic acid and checkpoint inhibitor for antitumor therapy |
| US20220362398A1 (en) * | 2019-04-26 | 2022-11-17 | Exicure Operating Company | Administration of spherical nucleic acids for ophthalmological uses |
-
2022
- 2022-01-11 EP EP22739945.8A patent/EP4277590A4/en active Pending
- 2022-01-11 CN CN202280012579.6A patent/CN116940324A/zh active Pending
- 2022-01-11 US US18/271,782 patent/US20240309367A1/en active Pending
- 2022-01-11 WO PCT/US2022/012023 patent/WO2022155149A1/en not_active Ceased
- 2022-01-11 JP JP2023541965A patent/JP2024505151A/ja active Pending
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