JP2024502282A - 細胞死誘導dffa様エフェクターb(cideb)阻害剤での肝疾患の治療 - Google Patents

細胞死誘導dffa様エフェクターb(cideb)阻害剤での肝疾患の治療 Download PDF

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JP2024502282A
JP2024502282A JP2023538855A JP2023538855A JP2024502282A JP 2024502282 A JP2024502282 A JP 2024502282A JP 2023538855 A JP2023538855 A JP 2023538855A JP 2023538855 A JP2023538855 A JP 2023538855A JP 2024502282 A JP2024502282 A JP 2024502282A
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nucleic acid
cideb
acid molecule
subject
inhibitor
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JP2024502282A5 (https=
Inventor
フェルヴァイ、ニーク
アンドレア ロッタ、ルカ
バラス、アリス
ハース、メアリー
ニールセン、ヨナス
ソシナ、オルカヨデ
ロック、アダム
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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JP2023538855A 2020-12-23 2021-12-22 細胞死誘導dffa様エフェクターb(cideb)阻害剤での肝疾患の治療 Pending JP2024502282A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US202063129725P 2020-12-23 2020-12-23
US63/129,725 2020-12-23
US202163149258P 2021-02-13 2021-02-13
US63/149,258 2021-02-13
US202163246101P 2021-09-20 2021-09-20
US63/246,101 2021-09-20
US202163257137P 2021-10-19 2021-10-19
US63/257,137 2021-10-19
PCT/US2021/064987 WO2022140624A1 (en) 2020-12-23 2021-12-22 Treatment of liver diseases with cell death inducing dffa like effector b (cideb) inhibitors

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JP2024502282A true JP2024502282A (ja) 2024-01-18
JP2024502282A5 JP2024502282A5 (https=) 2024-12-05

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JP2023538855A Pending JP2024502282A (ja) 2020-12-23 2021-12-22 細胞死誘導dffa様エフェクターb(cideb)阻害剤での肝疾患の治療

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US (3) US12018259B2 (https=)
EP (1) EP4267739A1 (https=)
JP (1) JP2024502282A (https=)
KR (1) KR20230124915A (https=)
CA (1) CA3201624A1 (https=)
IL (1) IL303536A (https=)
MX (1) MX2023007587A (https=)
WO (1) WO2022140624A1 (https=)

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JP2024538859A (ja) * 2021-08-31 2024-10-24 アルナイラム ファーマシューティカルズ, インコーポレイテッド 細胞死誘導DFFA様エフェクターB(CIDEB)iRNA組成物およびその使用方法
US20230193392A1 (en) 2021-12-20 2023-06-22 Regeneron Pharmaceuticals, Inc. Methods Of Identifying And Evaluating Liver Inflammation And Liver Fibrosis In A Subject By Determining A Stratified Score Based On Gene Expression
CN119278205A (zh) * 2022-04-07 2025-01-07 得克萨斯大学体系董事会 用靶向CIDEB的siRNA治疗肝病的组合物和方法
US20240071625A1 (en) * 2022-08-29 2024-02-29 Cedars-Sinai Medical Center Nafld identification and prediction systems and methods
WO2024109722A1 (zh) * 2022-11-21 2024-05-30 广州必贝特医药股份有限公司 用于抑制CIDEB基因表达的siRNA、药物及其应用
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AU2024243110A1 (en) * 2023-04-07 2025-11-06 Rona Bioscience, Limited Dsrna molecule for regulating expression of cideb mrna
CN118063533B (zh) * 2023-09-18 2024-08-27 广州必贝特医药股份有限公司 修饰的核苷酸化合物、其寡聚核苷酸及其应用
WO2025162435A1 (en) * 2024-02-02 2025-08-07 Accuredit Therapeutics (Suzhou) Co., Ltd. Compositions and methods for treatment of liver disease
WO2025178854A2 (en) * 2024-02-19 2025-08-28 Flagship Pioneering Innovations Vii, Llc Rnai agents targeting cideb and related methods
WO2025245188A2 (en) * 2024-05-21 2025-11-27 Flagship Pioneering Innovations Vii, Llc Methods of treating liver steatosis and non-alcoholic fatty liver disease

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MX2023007587A (es) 2023-09-21
AU2021410768A1 (en) 2023-06-22
US11773393B2 (en) 2023-10-03
US12018259B2 (en) 2024-06-25
US20220220474A1 (en) 2022-07-14
IL303536A (en) 2023-08-01
AU2021410768A9 (en) 2025-01-09
US20220282253A1 (en) 2022-09-08
KR20230124915A (ko) 2023-08-28
EP4267739A1 (en) 2023-11-01
US20240376471A1 (en) 2024-11-14
CA3201624A1 (en) 2022-06-30

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