KR20230124915A - 세포 사멸 유도 dffa 유사 이펙터 b(cideb) 억제제를 이용한 간 질환의 치료 - Google Patents
세포 사멸 유도 dffa 유사 이펙터 b(cideb) 억제제를 이용한 간 질환의 치료 Download PDFInfo
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- KR20230124915A KR20230124915A KR1020237020837A KR20237020837A KR20230124915A KR 20230124915 A KR20230124915 A KR 20230124915A KR 1020237020837 A KR1020237020837 A KR 1020237020837A KR 20237020837 A KR20237020837 A KR 20237020837A KR 20230124915 A KR20230124915 A KR 20230124915A
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/122—Hairpin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/34—Allele or polymorphism specific uses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Lubricants (AREA)
- Pens And Brushes (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063129725P | 2020-12-23 | 2020-12-23 | |
| US63/129,725 | 2020-12-23 | ||
| US202163149258P | 2021-02-13 | 2021-02-13 | |
| US63/149,258 | 2021-02-13 | ||
| US202163246101P | 2021-09-20 | 2021-09-20 | |
| US63/246,101 | 2021-09-20 | ||
| US202163257137P | 2021-10-19 | 2021-10-19 | |
| US63/257,137 | 2021-10-19 | ||
| PCT/US2021/064987 WO2022140624A1 (en) | 2020-12-23 | 2021-12-22 | Treatment of liver diseases with cell death inducing dffa like effector b (cideb) inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20230124915A true KR20230124915A (ko) | 2023-08-28 |
Family
ID=80001294
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020237020837A Pending KR20230124915A (ko) | 2020-12-23 | 2021-12-22 | 세포 사멸 유도 dffa 유사 이펙터 b(cideb) 억제제를 이용한 간 질환의 치료 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US12018259B2 (https=) |
| EP (1) | EP4267739A1 (https=) |
| JP (1) | JP2024502282A (https=) |
| KR (1) | KR20230124915A (https=) |
| CA (1) | CA3201624A1 (https=) |
| IL (1) | IL303536A (https=) |
| MX (1) | MX2023007587A (https=) |
| WO (1) | WO2022140624A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2024538859A (ja) * | 2021-08-31 | 2024-10-24 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | 細胞死誘導DFFA様エフェクターB(CIDEB)iRNA組成物およびその使用方法 |
| US20230193392A1 (en) | 2021-12-20 | 2023-06-22 | Regeneron Pharmaceuticals, Inc. | Methods Of Identifying And Evaluating Liver Inflammation And Liver Fibrosis In A Subject By Determining A Stratified Score Based On Gene Expression |
| CN119278205A (zh) * | 2022-04-07 | 2025-01-07 | 得克萨斯大学体系董事会 | 用靶向CIDEB的siRNA治疗肝病的组合物和方法 |
| US20240071625A1 (en) * | 2022-08-29 | 2024-02-29 | Cedars-Sinai Medical Center | Nafld identification and prediction systems and methods |
| WO2024109722A1 (zh) * | 2022-11-21 | 2024-05-30 | 广州必贝特医药股份有限公司 | 用于抑制CIDEB基因表达的siRNA、药物及其应用 |
| WO2024188164A1 (en) * | 2023-03-10 | 2024-09-19 | Shanghai Argo Biopharmaceutical Co., Ltd. | Compositions and methods for inhibiting expression of cell death inducing dffa like effector b (cideb) |
| AU2024243110A1 (en) * | 2023-04-07 | 2025-11-06 | Rona Bioscience, Limited | Dsrna molecule for regulating expression of cideb mrna |
| CN118063533B (zh) * | 2023-09-18 | 2024-08-27 | 广州必贝特医药股份有限公司 | 修饰的核苷酸化合物、其寡聚核苷酸及其应用 |
| WO2025162435A1 (en) * | 2024-02-02 | 2025-08-07 | Accuredit Therapeutics (Suzhou) Co., Ltd. | Compositions and methods for treatment of liver disease |
| WO2025178854A2 (en) * | 2024-02-19 | 2025-08-28 | Flagship Pioneering Innovations Vii, Llc | Rnai agents targeting cideb and related methods |
| WO2025245188A2 (en) * | 2024-05-21 | 2025-11-27 | Flagship Pioneering Innovations Vii, Llc | Methods of treating liver steatosis and non-alcoholic fatty liver disease |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007538093A (ja) | 2004-05-19 | 2007-12-27 | ナチュラル ソース インターナショナル | 前立腺癌の治療および予防におけるフラボペレイリンとアルストニンとの併用 |
| EP2105511A1 (en) | 2008-03-28 | 2009-09-30 | Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung e.V. | Medicament compositions and substances for treatment and identifying adenocarcinoma of the lung |
| CN102300578A (zh) | 2008-12-01 | 2011-12-28 | 延寿有限责任公司 | 用于改变健康、安康和寿命的方法和组合物 |
| KR20110111474A (ko) | 2009-01-09 | 2011-10-11 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 암에서의 반복적 유전자 융합체 |
| FR2940910A1 (fr) | 2009-01-09 | 2010-07-16 | Vetoquinol Sa | Nouveau comprime a base de s-adenosyl-methionine |
| US8445207B2 (en) | 2009-04-07 | 2013-05-21 | Korea Institute Of Science And Technology | Genes based on thalidomide, valproic acid and methotrexate treatment for screening of drug inducing teratogenicity and screening method using thereof |
| CN102481271A (zh) | 2009-05-11 | 2012-05-30 | 博格生物系统有限责任公司 | 利用表观代谢转变剂、多维细胞内分子或环境影响剂治疗代谢障碍的方法 |
| KR101886342B1 (ko) | 2010-11-30 | 2018-08-10 | (주)아모레퍼시픽 | 피부 노화와 관련된 유전자 및 피부 노화를 방지하는 물질을 스크리닝하는 방법 |
| WO2012149386A1 (en) | 2011-04-27 | 2012-11-01 | Isis Pharmaceuticals, Inc. | Modulation of cideb expression |
| WO2013022821A1 (en) | 2011-08-05 | 2013-02-14 | Gen-Probe Incorporated | Antiandrogen therapy monitoring methods and compositions |
| WO2013022872A1 (en) | 2011-08-10 | 2013-02-14 | Celgene Corporation | Gene methylation biomarkers and methods of use thereof |
| US20140342946A1 (en) | 2011-12-31 | 2014-11-20 | Moni Abraham Kuriakose | Diagnostic tests for predicting prognosis, recurrence, resistance or sensitivity to therapy and metastatic status in cancer |
| WO2014089121A2 (en) | 2012-12-03 | 2014-06-12 | Thomas Ichim | Retrograde delivery of cells and nucleic acids for treatment of cardiovascular diseases |
| CA2976445A1 (en) * | 2015-02-13 | 2016-08-18 | Alnylam Pharmaceuticals, Inc. | Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof |
| WO2016175913A1 (en) | 2015-04-27 | 2016-11-03 | Roseman University Of Health Sciences | Methods for therapeutic targeting of circulating tumor cells during hemodialysis |
| WO2017067477A1 (en) | 2015-10-20 | 2017-04-27 | Hung-Cheng Lai | Methods for making diagnosis and/or prognosis of gynecologic neoplasm |
| US20190071795A1 (en) | 2016-03-09 | 2019-03-07 | Molecular Stethoscope, Inc. | Methods and systems for detecting tissue conditions |
| WO2017191274A2 (en) | 2016-05-04 | 2017-11-09 | Curevac Ag | Rna encoding a therapeutic protein |
| AU2018348195B2 (en) | 2017-10-11 | 2025-05-15 | Regeneron Pharmaceuticals, Inc. | Inhibition of HSD17B13 in the treatment of liver disease in patients expressing the PNPLA3 I148M variation |
| WO2019140380A1 (en) | 2018-01-12 | 2019-07-18 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| US20210000906A1 (en) | 2018-03-21 | 2021-01-07 | Ionis Pharmaceuticals, Inc. | Modulation of hsd17b13 expression |
| AU2019239971B2 (en) | 2018-03-21 | 2025-09-11 | Regeneron Pharmaceuticals, Inc. | 17beta-hydroxysteroid dehydrogenase type 13 (HSD17b13) iRNA compositions and methods of use thereof |
| MX2020013994A (es) | 2018-06-22 | 2021-05-27 | Bluestar Genomics Inc | Análisis de hidroximetilación de muestras de ácido nucleico sin células para asignación de tejido de origen, y métodos relacionados de uso. |
| US11021545B2 (en) | 2018-07-31 | 2021-06-01 | The Regents Of The University Of California | Multimodal cancer therapy comprising chimeric viral/nonviral nanoparticles and anticancer agents |
| KR102769565B1 (ko) | 2018-09-19 | 2025-02-20 | 애로우헤드 파마슈티컬스 인코포레이티드 | 17베타-HSD 유형 13- (HSD17B13)의 발현을 억제하기 위한 RNAi 작용제, 그의 조성물, 및 사용 방법 |
-
2021
- 2021-12-22 MX MX2023007587A patent/MX2023007587A/es unknown
- 2021-12-22 EP EP21848076.2A patent/EP4267739A1/en active Pending
- 2021-12-22 JP JP2023538855A patent/JP2024502282A/ja active Pending
- 2021-12-22 WO PCT/US2021/064987 patent/WO2022140624A1/en not_active Ceased
- 2021-12-22 CA CA3201624A patent/CA3201624A1/en active Pending
- 2021-12-22 IL IL303536A patent/IL303536A/en unknown
- 2021-12-22 KR KR1020237020837A patent/KR20230124915A/ko active Pending
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2022
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2024
- 2024-05-10 US US18/660,837 patent/US20240376471A1/en active Pending
Also Published As
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| WO2022140624A1 (en) | 2022-06-30 |
| MX2023007587A (es) | 2023-09-21 |
| AU2021410768A1 (en) | 2023-06-22 |
| US11773393B2 (en) | 2023-10-03 |
| US12018259B2 (en) | 2024-06-25 |
| US20220220474A1 (en) | 2022-07-14 |
| IL303536A (en) | 2023-08-01 |
| AU2021410768A9 (en) | 2025-01-09 |
| US20220282253A1 (en) | 2022-09-08 |
| EP4267739A1 (en) | 2023-11-01 |
| US20240376471A1 (en) | 2024-11-14 |
| JP2024502282A (ja) | 2024-01-18 |
| CA3201624A1 (en) | 2022-06-30 |
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