JP2024502282A5 - - Google Patents
Info
- Publication number
- JP2024502282A5 JP2024502282A5 JP2023538855A JP2023538855A JP2024502282A5 JP 2024502282 A5 JP2024502282 A5 JP 2024502282A5 JP 2023538855 A JP2023538855 A JP 2023538855A JP 2023538855 A JP2023538855 A JP 2023538855A JP 2024502282 A5 JP2024502282 A5 JP 2024502282A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid molecule
- cideb
- use according
- pnpla3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063129725P | 2020-12-23 | 2020-12-23 | |
| US63/129,725 | 2020-12-23 | ||
| US202163149258P | 2021-02-13 | 2021-02-13 | |
| US63/149,258 | 2021-02-13 | ||
| US202163246101P | 2021-09-20 | 2021-09-20 | |
| US63/246,101 | 2021-09-20 | ||
| US202163257137P | 2021-10-19 | 2021-10-19 | |
| US63/257,137 | 2021-10-19 | ||
| PCT/US2021/064987 WO2022140624A1 (en) | 2020-12-23 | 2021-12-22 | Treatment of liver diseases with cell death inducing dffa like effector b (cideb) inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024502282A JP2024502282A (ja) | 2024-01-18 |
| JP2024502282A5 true JP2024502282A5 (https=) | 2024-12-05 |
Family
ID=80001294
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023538855A Pending JP2024502282A (ja) | 2020-12-23 | 2021-12-22 | 細胞死誘導ｄｆｆａ様エフェクターｂ（ｃｉｄｅｂ）阻害剤での肝疾患の治療 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US12018259B2 (https=) |
| EP (1) | EP4267739A1 (https=) |
| JP (1) | JP2024502282A (https=) |
| KR (1) | KR20230124915A (https=) |
| CA (1) | CA3201624A1 (https=) |
| IL (1) | IL303536A (https=) |
| MX (1) | MX2023007587A (https=) |
| WO (1) | WO2022140624A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2024538859A (ja) * | 2021-08-31 | 2024-10-24 | アルナイラム ファーマシューティカルズ， インコーポレイテッド | 細胞死誘導ＤＦＦＡ様エフェクターＢ（ＣＩＤＥＢ）ｉＲＮＡ組成物およびその使用方法 |
| US20230193392A1 (en) | 2021-12-20 | 2023-06-22 | Regeneron Pharmaceuticals, Inc. | Methods Of Identifying And Evaluating Liver Inflammation And Liver Fibrosis In A Subject By Determining A Stratified Score Based On Gene Expression |
| CN119278205A (zh) * | 2022-04-07 | 2025-01-07 | 得克萨斯大学体系董事会 | 用靶向CIDEB的siRNA治疗肝病的组合物和方法 |
| US20240071625A1 (en) * | 2022-08-29 | 2024-02-29 | Cedars-Sinai Medical Center | Nafld identification and prediction systems and methods |
| WO2024109722A1 (zh) * | 2022-11-21 | 2024-05-30 | 广州必贝特医药股份有限公司 | 用于抑制CIDEB基因表达的siRNA、药物及其应用 |
| WO2024188164A1 (en) * | 2023-03-10 | 2024-09-19 | Shanghai Argo Biopharmaceutical Co., Ltd. | Compositions and methods for inhibiting expression of cell death inducing dffa like effector b (cideb) |
| AU2024243110A1 (en) * | 2023-04-07 | 2025-11-06 | Rona Bioscience, Limited | Dsrna molecule for regulating expression of cideb mrna |
| CN118063533B (zh) * | 2023-09-18 | 2024-08-27 | 广州必贝特医药股份有限公司 | 修饰的核苷酸化合物、其寡聚核苷酸及其应用 |
| WO2025162435A1 (en) * | 2024-02-02 | 2025-08-07 | Accuredit Therapeutics (Suzhou) Co., Ltd. | Compositions and methods for treatment of liver disease |
| WO2025178854A2 (en) * | 2024-02-19 | 2025-08-28 | Flagship Pioneering Innovations Vii, Llc | Rnai agents targeting cideb and related methods |
| WO2025245188A2 (en) * | 2024-05-21 | 2025-11-27 | Flagship Pioneering Innovations Vii, Llc | Methods of treating liver steatosis and non-alcoholic fatty liver disease |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007538093A (ja) | 2004-05-19 | 2007-12-27 | ナチュラル ソース インターナショナル | 前立腺癌の治療および予防におけるフラボペレイリンとアルストニンとの併用 |
| EP2105511A1 (en) | 2008-03-28 | 2009-09-30 | Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung e.V. | Medicament compositions and substances for treatment and identifying adenocarcinoma of the lung |
| CN102300578A (zh) | 2008-12-01 | 2011-12-28 | 延寿有限责任公司 | 用于改变健康、安康和寿命的方法和组合物 |
| KR20110111474A (ko) | 2009-01-09 | 2011-10-11 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 암에서의 반복적 유전자 융합체 |
| FR2940910A1 (fr) | 2009-01-09 | 2010-07-16 | Vetoquinol Sa | Nouveau comprime a base de s-adenosyl-methionine |
| US8445207B2 (en) | 2009-04-07 | 2013-05-21 | Korea Institute Of Science And Technology | Genes based on thalidomide, valproic acid and methotrexate treatment for screening of drug inducing teratogenicity and screening method using thereof |
| CN102481271A (zh) | 2009-05-11 | 2012-05-30 | 博格生物系统有限责任公司 | 利用表观代谢转变剂、多维细胞内分子或环境影响剂治疗代谢障碍的方法 |
| KR101886342B1 (ko) | 2010-11-30 | 2018-08-10 | (주)아모레퍼시픽 | 피부 노화와 관련된 유전자 및 피부 노화를 방지하는 물질을 스크리닝하는 방법 |
| WO2012149386A1 (en) | 2011-04-27 | 2012-11-01 | Isis Pharmaceuticals, Inc. | Modulation of cideb expression |
| WO2013022821A1 (en) | 2011-08-05 | 2013-02-14 | Gen-Probe Incorporated | Antiandrogen therapy monitoring methods and compositions |
| WO2013022872A1 (en) | 2011-08-10 | 2013-02-14 | Celgene Corporation | Gene methylation biomarkers and methods of use thereof |
| US20140342946A1 (en) | 2011-12-31 | 2014-11-20 | Moni Abraham Kuriakose | Diagnostic tests for predicting prognosis, recurrence, resistance or sensitivity to therapy and metastatic status in cancer |
| WO2014089121A2 (en) | 2012-12-03 | 2014-06-12 | Thomas Ichim | Retrograde delivery of cells and nucleic acids for treatment of cardiovascular diseases |
| CA2976445A1 (en) * | 2015-02-13 | 2016-08-18 | Alnylam Pharmaceuticals, Inc. | Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof |
| WO2016175913A1 (en) | 2015-04-27 | 2016-11-03 | Roseman University Of Health Sciences | Methods for therapeutic targeting of circulating tumor cells during hemodialysis |
| WO2017067477A1 (en) | 2015-10-20 | 2017-04-27 | Hung-Cheng Lai | Methods for making diagnosis and/or prognosis of gynecologic neoplasm |
| US20190071795A1 (en) | 2016-03-09 | 2019-03-07 | Molecular Stethoscope, Inc. | Methods and systems for detecting tissue conditions |
| WO2017191274A2 (en) | 2016-05-04 | 2017-11-09 | Curevac Ag | Rna encoding a therapeutic protein |
| AU2018348195B2 (en) | 2017-10-11 | 2025-05-15 | Regeneron Pharmaceuticals, Inc. | Inhibition of HSD17B13 in the treatment of liver disease in patients expressing the PNPLA3 I148M variation |
| WO2019140380A1 (en) | 2018-01-12 | 2019-07-18 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| US20210000906A1 (en) | 2018-03-21 | 2021-01-07 | Ionis Pharmaceuticals, Inc. | Modulation of hsd17b13 expression |
| AU2019239971B2 (en) | 2018-03-21 | 2025-09-11 | Regeneron Pharmaceuticals, Inc. | 17beta-hydroxysteroid dehydrogenase type 13 (HSD17b13) iRNA compositions and methods of use thereof |
| MX2020013994A (es) | 2018-06-22 | 2021-05-27 | Bluestar Genomics Inc | Análisis de hidroximetilación de muestras de ácido nucleico sin células para asignación de tejido de origen, y métodos relacionados de uso. |
| US11021545B2 (en) | 2018-07-31 | 2021-06-01 | The Regents Of The University Of California | Multimodal cancer therapy comprising chimeric viral/nonviral nanoparticles and anticancer agents |
| KR102769565B1 (ko) | 2018-09-19 | 2025-02-20 | 애로우헤드 파마슈티컬스 인코포레이티드 | 17베타-HSD 유형 13- (HSD17B13)의 발현을 억제하기 위한 RNAi 작용제, 그의 조성물, 및 사용 방법 |
-
2021
- 2021-12-22 MX MX2023007587A patent/MX2023007587A/es unknown
- 2021-12-22 EP EP21848076.2A patent/EP4267739A1/en active Pending
- 2021-12-22 JP JP2023538855A patent/JP2024502282A/ja active Pending
- 2021-12-22 WO PCT/US2021/064987 patent/WO2022140624A1/en not_active Ceased
- 2021-12-22 CA CA3201624A patent/CA3201624A1/en active Pending
- 2021-12-22 IL IL303536A patent/IL303536A/en unknown
- 2021-12-22 KR KR1020237020837A patent/KR20230124915A/ko active Pending
- 2021-12-22 US US17/560,008 patent/US12018259B2/en active Active
-
2022
- 2022-03-31 US US17/709,705 patent/US11773393B2/en active Active
-
2024
- 2024-05-10 US US18/660,837 patent/US20240376471A1/en active Pending
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