JP2024170457A5 - - Google Patents
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- Publication number
- JP2024170457A5 JP2024170457A5 JP2024145040A JP2024145040A JP2024170457A5 JP 2024170457 A5 JP2024170457 A5 JP 2024170457A5 JP 2024145040 A JP2024145040 A JP 2024145040A JP 2024145040 A JP2024145040 A JP 2024145040A JP 2024170457 A5 JP2024170457 A5 JP 2024170457A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- following structure
- compound
- activity
- inflammatory
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 4
- 101001089266 Homo sapiens Receptor-interacting serine/threonine-protein kinase 3 Proteins 0.000 claims 3
- 208000004852 Lung Injury Diseases 0.000 claims 3
- 102100033729 Receptor-interacting serine/threonine-protein kinase 3 Human genes 0.000 claims 3
- 206010069363 Traumatic lung injury Diseases 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 208000027866 inflammatory disease Diseases 0.000 claims 3
- 230000002757 inflammatory effect Effects 0.000 claims 3
- 231100000515 lung injury Toxicity 0.000 claims 3
- 208000015122 neurodegenerative disease Diseases 0.000 claims 3
- 125000006414 CCl Chemical group ClC* 0.000 claims 2
- 241000712431 Influenza A virus Species 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 229910014033 C-OH Inorganic materials 0.000 claims 1
- 229910014570 C—OH Inorganic materials 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 102000001253 Protein Kinase Human genes 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000002956 necrotizing effect Effects 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 108060006633 protein kinase Proteins 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962848719P | 2019-05-16 | 2019-05-16 | |
| US201962848648P | 2019-05-16 | 2019-05-16 | |
| US62/848,648 | 2019-05-16 | ||
| US62/848,719 | 2019-05-16 | ||
| PCT/US2020/032784 WO2020232190A1 (en) | 2019-05-16 | 2020-05-14 | Protein kinase inhibitors and uses thereof for the treatment of diseases and conditions |
| JP2021568650A JP7546603B2 (ja) | 2019-05-16 | 2020-05-14 | タンパク質キナーゼ阻害剤ならびに疾患および状態の治療のためのその使用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021568650A Division JP7546603B2 (ja) | 2019-05-16 | 2020-05-14 | タンパク質キナーゼ阻害剤ならびに疾患および状態の治療のためのその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024170457A JP2024170457A (ja) | 2024-12-10 |
| JP2024170457A5 true JP2024170457A5 (enExample) | 2024-12-19 |
Family
ID=70919255
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021568650A Active JP7546603B2 (ja) | 2019-05-16 | 2020-05-14 | タンパク質キナーゼ阻害剤ならびに疾患および状態の治療のためのその使用 |
| JP2024145040A Pending JP2024170457A (ja) | 2019-05-16 | 2024-08-27 | タンパク質キナーゼ阻害剤ならびに疾患および状態の治療のためのその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021568650A Active JP7546603B2 (ja) | 2019-05-16 | 2020-05-14 | タンパク質キナーゼ阻害剤ならびに疾患および状態の治療のためのその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20220194937A1 (enExample) |
| EP (2) | EP4480485A3 (enExample) |
| JP (2) | JP7546603B2 (enExample) |
| AU (1) | AU2020275304B2 (enExample) |
| CA (1) | CA3137869A1 (enExample) |
| WO (1) | WO2020232190A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11174255B2 (en) * | 2017-05-15 | 2021-11-16 | University Of Houston System | Pyrido[2,3-d]pyrimidin-7-ones and related compounds as inhibitors of protein kinases |
| US20220194937A1 (en) * | 2019-05-16 | 2022-06-23 | University Of Houston System | Protein kinase inhibitors and uses thereof for the treatment of diseases and conditions |
| CN113072471B (zh) * | 2021-03-02 | 2022-09-16 | 四川美大康华康药业有限公司 | 一种利非司特中间体及其制备方法 |
| WO2024097805A1 (en) * | 2022-11-01 | 2024-05-10 | Trustees Of Tufts College | Mixed lineage kinase domain like pseudokinase (mlkl) activators |
| WO2024199388A1 (zh) * | 2023-03-29 | 2024-10-03 | 微境生物医药科技(上海)有限公司 | 作为myt1抑制剂的化合物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL117923A (en) * | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
| WO1999009030A1 (en) * | 1997-08-20 | 1999-02-25 | Warner-Lambert Company | Naphthyridinones for inhibiting protein tyrosine kinase and cell cycle kinase mediated cellular proliferation |
| HUP0203803A3 (en) * | 2000-01-27 | 2004-09-28 | Warner Lambert Co | Pyridopyrimidinone derivatives for treatment of neurodegenerative disease |
| WO2014031571A1 (en) * | 2012-08-21 | 2014-02-27 | Icahn School Of Medicine At Mount Sinai | Treatment of viral infections |
| WO2015179436A1 (en) * | 2014-05-19 | 2015-11-26 | Sanford-Burnham Medical Research Institute | Inflammation therapy using mekk3 inhibitors or blocking peptides |
| US11174255B2 (en) * | 2017-05-15 | 2021-11-16 | University Of Houston System | Pyrido[2,3-d]pyrimidin-7-ones and related compounds as inhibitors of protein kinases |
| US20220194937A1 (en) * | 2019-05-16 | 2022-06-23 | University Of Houston System | Protein kinase inhibitors and uses thereof for the treatment of diseases and conditions |
-
2020
- 2020-05-14 US US17/595,406 patent/US20220194937A1/en active Pending
- 2020-05-14 EP EP24191377.1A patent/EP4480485A3/en active Pending
- 2020-05-14 JP JP2021568650A patent/JP7546603B2/ja active Active
- 2020-05-14 AU AU2020275304A patent/AU2020275304B2/en active Active
- 2020-05-14 WO PCT/US2020/032784 patent/WO2020232190A1/en not_active Ceased
- 2020-05-14 CA CA3137869A patent/CA3137869A1/en active Pending
- 2020-05-14 EP EP20729566.8A patent/EP3968991B1/en active Active
-
2024
- 2024-08-27 JP JP2024145040A patent/JP2024170457A/ja active Pending
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