JP2024103495A5 - - Google Patents
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- JP2024103495A5 JP2024103495A5 JP2024074818A JP2024074818A JP2024103495A5 JP 2024103495 A5 JP2024103495 A5 JP 2024103495A5 JP 2024074818 A JP2024074818 A JP 2024074818A JP 2024074818 A JP2024074818 A JP 2024074818A JP 2024103495 A5 JP2024103495 A5 JP 2024103495A5
- Authority
- JP
- Japan
- Prior art keywords
- crystal
- measured
- ray powder
- powder diffraction
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000013078 crystal Substances 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 4
- 238000000634 powder X-ray diffraction Methods 0.000 claims 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 206010025323 Lymphomas Diseases 0.000 claims 2
- RNULKRJBTXBTBX-UGVMAUAESA-N OC1=C(C=CC2=CC=CC=C12)C(=O)O.N[C@@H]1CC[C@H](CC1)NC(O)=O Chemical compound OC1=C(C=CC2=CC=CC=C12)C(=O)O.N[C@@H]1CC[C@H](CC1)NC(O)=O RNULKRJBTXBTBX-UGVMAUAESA-N 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims 2
- 238000000113 differential scanning calorimetry Methods 0.000 claims 1
- 238000004455 differential thermal analysis Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
- 238000002411 thermogravimetry Methods 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562265675P | 2015-12-10 | 2015-12-10 | |
| US62/265,675 | 2015-12-10 | ||
| PCT/US2016/065799 WO2017100553A1 (en) | 2015-12-10 | 2016-12-09 | Fumagillol derivatives and polymorphs thereof |
| JP2018529646A JP7553224B2 (ja) | 2015-12-10 | 2016-12-09 | フマギロール誘導体およびその多形体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018529646A Division JP7553224B2 (ja) | 2015-12-10 | 2016-12-09 | フマギロール誘導体およびその多形体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024103495A JP2024103495A (ja) | 2024-08-01 |
| JP2024103495A5 true JP2024103495A5 (enExample) | 2024-11-25 |
Family
ID=57589276
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018529646A Active JP7553224B2 (ja) | 2015-12-10 | 2016-12-09 | フマギロール誘導体およびその多形体 |
| JP2024074818A Pending JP2024103495A (ja) | 2015-12-10 | 2024-05-02 | フマギロール誘導体およびその多形体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018529646A Active JP7553224B2 (ja) | 2015-12-10 | 2016-12-09 | フマギロール誘導体およびその多形体 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9969722B2 (enExample) |
| EP (1) | EP3386956B1 (enExample) |
| JP (2) | JP7553224B2 (enExample) |
| KR (2) | KR102849342B1 (enExample) |
| CN (1) | CN108290853B (enExample) |
| AU (1) | AU2016366306B2 (enExample) |
| CA (1) | CA3005450A1 (enExample) |
| DK (1) | DK3386956T3 (enExample) |
| ES (1) | ES2893749T3 (enExample) |
| MX (2) | MX2018006904A (enExample) |
| WO (1) | WO2017100553A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2576638B1 (en) | 2010-05-25 | 2020-12-23 | Syndevrx, Inc. | Polymer-conjugated metap2 inhibitors, and therapeutic methods of use thereof |
| BR112015025892A2 (pt) | 2013-04-10 | 2017-07-25 | Syndevrx Inc | inibidores de metap2 e métodos para tratar obesidade |
| DK3386956T3 (da) * | 2015-12-10 | 2021-10-11 | Syndevrx Inc | Fumagillolderivater og polymorfer deraf |
| CA3239447A1 (en) | 2016-01-11 | 2017-07-20 | Syndevrx, Inc. | Treatment for tumors driven by metabolic dysfunction |
| CA3117666A1 (en) | 2018-10-26 | 2020-04-30 | Syndevrx, Inc. | Biomarkers of metap2 inhibitors and applications thereof |
| WO2024040009A2 (en) * | 2022-08-17 | 2024-02-22 | Primetime Life Sciences, Llc | Inhibitors of methionine aminopeptidase-2 and methods of preparation and uses thereof |
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| GB8500209D0 (en) | 1985-01-04 | 1985-02-13 | Ceskoslovenska Akademie Ved | Synthetic polymeric drugs |
| SE8702550D0 (sv) | 1987-06-18 | 1987-06-18 | Anders Grubb | Cysteinproteashemmare |
| US5166172A (en) | 1988-09-01 | 1992-11-24 | Takeda Chemical Industries, Ltd. | Fumagillol derivatives and pharmaceutical compositions thereof |
| US4997878A (en) | 1988-12-29 | 1991-03-05 | Exxon Research And Engineering Company | Hydrophobically associating polymers containing dimethyl acrylamide functionality |
| US5258453A (en) | 1992-01-21 | 1993-11-02 | University Of Utah | Drug delivery system for the simultaneous delivery of drugs activatable by enzymes and light |
| GB9320781D0 (en) | 1993-10-08 | 1993-12-01 | Erba Carlo Spa | Polymer-bound camptothecin derivatives |
| US20030220233A1 (en) | 1994-01-24 | 2003-11-27 | Neorx Corporation | Radiolabeled annexins |
| TW527183B (en) | 1996-06-06 | 2003-04-11 | Daiichi Seiyaku Co | Drug complex |
| TW409058B (en) | 1996-06-06 | 2000-10-21 | Daiichi Seiyaku Co | Method for preparation of a drug complex |
| US6759509B1 (en) | 1996-11-05 | 2004-07-06 | Bristol-Myers Squibb Company | Branched peptide linkers |
| AU9376998A (en) | 1997-09-02 | 1999-03-22 | Johns Hopkins University School Of Medicine, The | Vitamin d3 analog loaded polymer formulations for cancer and neurodegenerative disorders |
| JP2002502814A (ja) | 1997-10-31 | 2002-01-29 | チルドレンズ・メディカル・センター・コーポレイション | 血管化した正常組織の大きさおよび増殖の調節のための方法 |
| KR100357542B1 (ko) | 1998-05-15 | 2002-10-18 | 주식회사종근당 | 푸마질롤 유도체 및 그 제조방법 |
| EA003398B1 (ru) | 1998-05-22 | 2003-04-24 | Дайити Фармасьютикал Ко., Лтд. | Лекарственный комплекс c полимерным носителем |
| US6464850B1 (en) | 1998-07-31 | 2002-10-15 | Biowhittaker Molecular Applications, Inc. | Method for producing hydrophilic monomers and uses thereof |
| HK1042438A1 (zh) | 1998-10-30 | 2002-08-16 | 第一制药株式会社 | Dds化合物及其测定方法 |
| AU7025600A (en) | 1999-09-08 | 2001-04-10 | School Of Pharmacy, University Of London, The | Uniform molecular weight polymers |
| US6811788B2 (en) | 2000-01-19 | 2004-11-02 | Baofa Yu | Combinations and methods for treating neoplasms |
| US6548477B1 (en) | 2000-11-01 | 2003-04-15 | Praecis Pharmaceuticals Inc. | Therapeutic agents and methods of use thereof for the modulation of angiogenesis |
| US20070161570A1 (en) | 2000-11-01 | 2007-07-12 | Praecis Pharmaceuticals, Inc. | Methionine aminopeptidase-2 inhibitors and methods of use thereof |
| EP1243276A1 (en) | 2001-03-23 | 2002-09-25 | Franciscus Marinus Hendrikus De Groot | Elongated and multiple spacers containing activatible prodrugs |
| US7091186B2 (en) | 2001-09-24 | 2006-08-15 | Seattle Genetics, Inc. | p-Amidobenzylethers in drug delivery agents |
| DE60233420D1 (de) | 2001-09-27 | 2009-10-01 | Equispharm Co Ltd | Fumagillolderivate und verfahren zu deren herstellung |
| WO2003070173A2 (en) | 2002-02-15 | 2003-08-28 | Sympore Gmbh | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof |
| AU2003230852B2 (en) | 2002-04-11 | 2008-07-10 | Children's Medical Center Corporation | TNP-470 polymer conjugates and use thereof |
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| US20040116348A1 (en) | 2002-09-23 | 2004-06-17 | Ying Chau | Polymer-linker-drug conjugates for targeted drug delivery |
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| ES2394799T3 (es) | 2003-12-31 | 2013-02-05 | The Penn State Research Foundation | Métodos para predecir y superar la resistencia a quimioterapia en cáncer de ovario |
| US20070287680A1 (en) | 2004-05-10 | 2007-12-13 | University Of Utah Research Foundation | Combined Active and Passive Targeting of Biologically Active Agents |
| US7214664B2 (en) | 2004-12-03 | 2007-05-08 | The Curators Of The University Of Missouri | Peptidyl prodrugs that resist P-glycoprotein mediated drug efflux |
| US20080248030A1 (en) | 2005-02-02 | 2008-10-09 | Children's Medical Center Corporation | Method of Treating Angiogenic Diseases |
| US7629315B2 (en) | 2005-03-09 | 2009-12-08 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Compositions for blocking the inhibitory effect of human CRP on human leptin |
| WO2006124711A1 (en) | 2005-05-16 | 2006-11-23 | The Board Of Trustees Of The University Of Illinois | Composition and method for providing localized delivery of a therapeutic agent |
| WO2011053822A2 (en) | 2009-11-01 | 2011-05-05 | The Brigham And Women's Hospital, Inc. | Notch inhibition in the treatment and prevention of obesity and metabolic syndrome |
| CA2690244C (en) | 2007-06-26 | 2016-08-09 | Ofra Benny-Ratsaby | Metap-2 inhibitor polymersomes for therapeutic administration |
| WO2009036108A1 (en) | 2007-09-13 | 2009-03-19 | Children's Medical Center Corporation | Methods and compositions for inhibiting vascular leakage |
| US20090104210A1 (en) | 2007-10-17 | 2009-04-23 | Tota Michael R | Peptide compounds for treating obesity and insulin resistance |
| BRPI0820229A2 (pt) | 2007-11-28 | 2017-05-09 | A Stevenson Cheri | conjugados de análogos de fumagilina biodegradáveis biocompatíveis |
| US20100298371A1 (en) | 2007-12-04 | 2010-11-25 | Mayank Ghanshyambhai Dave | Process for preparing chemically and chirally pure solifenacin base and its salts |
| WO2009094155A1 (en) | 2008-01-22 | 2009-07-30 | Thar Pharmaceuticals | In vivo studies of crystalline forms of meloxicam |
| WO2009141826A2 (en) | 2008-05-22 | 2009-11-26 | Ramot At Tel Aviv University Ltd. | Novel conjugates of polymers having a therapeutically active agent and an angiogenesis targeting moiety attached thereto and uses thereof in the treatment of angiogenesis related diseases |
| DE102008027574A1 (de) | 2008-06-10 | 2009-12-17 | Merck Patent Gmbh | Neue Pyrrolidinderivate als MetAP-2 Inhibitoren |
| WO2010065877A2 (en) | 2008-12-04 | 2010-06-10 | Zafgen Corporation | Methods of treating an overweight or obese subject |
| WO2010065883A2 (en) | 2008-12-04 | 2010-06-10 | Zafgen Corporation | Method of treating an overweight or obese subject |
| TWI373345B (en) | 2009-02-19 | 2012-10-01 | Academia Sinica | Breast cancer-targeting peptides and use thereof |
| WO2011127304A2 (en) | 2010-04-07 | 2011-10-13 | Zafgen Corporation | Methods of treating an overweight subject |
| EP2575887A4 (en) | 2010-05-25 | 2015-01-14 | SynDevRX | CONJUGATES OF OPTIMIZED MEDICINES |
| US9895449B2 (en) | 2010-05-25 | 2018-02-20 | Syndevrx, Inc. | Polymer-conjugated MetAP2 inhibitors, and therapeutic methods of use thereof |
| EP2576638B1 (en) | 2010-05-25 | 2020-12-23 | Syndevrx, Inc. | Polymer-conjugated metap2 inhibitors, and therapeutic methods of use thereof |
| PH12013500934A1 (en) | 2010-11-09 | 2022-10-24 | Zafgen Inc | Crystalline solids of a metap-2 inhibitor and methods of making and using same |
| EP2683706B1 (en) | 2011-03-08 | 2018-02-21 | Zafgen, Inc. | Oxaspiro [2.5]octane derivatives and analogs |
| JP6177888B2 (ja) * | 2012-05-09 | 2017-08-09 | ザフゲン，インコーポレイテッド | フマギロール型化合物ならびにその製造および使用方法 |
| BR112015025892A2 (pt) * | 2013-04-10 | 2017-07-25 | Syndevrx Inc | inibidores de metap2 e métodos para tratar obesidade |
| DK3386956T3 (da) * | 2015-12-10 | 2021-10-11 | Syndevrx Inc | Fumagillolderivater og polymorfer deraf |
| CA3239447A1 (en) | 2016-01-11 | 2017-07-20 | Syndevrx, Inc. | Treatment for tumors driven by metabolic dysfunction |
-
2016
- 2016-12-09 DK DK16816157.8T patent/DK3386956T3/da active
- 2016-12-09 KR KR1020187019456A patent/KR102849342B1/ko active Active
- 2016-12-09 ES ES16816157T patent/ES2893749T3/es active Active
- 2016-12-09 KR KR1020257027526A patent/KR20250127347A/ko active Pending
- 2016-12-09 MX MX2018006904A patent/MX2018006904A/es unknown
- 2016-12-09 CA CA3005450A patent/CA3005450A1/en active Pending
- 2016-12-09 US US15/373,874 patent/US9969722B2/en active Active
- 2016-12-09 WO PCT/US2016/065799 patent/WO2017100553A1/en not_active Ceased
- 2016-12-09 AU AU2016366306A patent/AU2016366306B2/en active Active
- 2016-12-09 CN CN201680072272.XA patent/CN108290853B/zh active Active
- 2016-12-09 EP EP16816157.8A patent/EP3386956B1/en active Active
- 2016-12-09 JP JP2018529646A patent/JP7553224B2/ja active Active
-
2018
- 2018-04-06 US US15/946,899 patent/US10287277B2/en active Active
- 2018-06-06 MX MX2023002589A patent/MX2023002589A/es unknown
-
2024
- 2024-05-02 JP JP2024074818A patent/JP2024103495A/ja active Pending
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