JP2024073531A5 - - Google Patents
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- Publication number
- JP2024073531A5 JP2024073531A5 JP2024038103A JP2024038103A JP2024073531A5 JP 2024073531 A5 JP2024073531 A5 JP 2024073531A5 JP 2024038103 A JP2024038103 A JP 2024038103A JP 2024038103 A JP2024038103 A JP 2024038103A JP 2024073531 A5 JP2024073531 A5 JP 2024073531A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- polypeptide
- variable domain
- pichia host
- immunoglobulin single
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000235648 Pichia Species 0.000 claims 53
- 102000039446 nucleic acids Human genes 0.000 claims 52
- 108020004707 nucleic acids Proteins 0.000 claims 52
- 150000007523 nucleic acids Chemical class 0.000 claims 52
- 238000000034 method Methods 0.000 claims 46
- 108090000765 processed proteins & peptides Proteins 0.000 claims 40
- 229920001184 polypeptide Polymers 0.000 claims 39
- 102000004196 processed proteins & peptides Human genes 0.000 claims 39
- 230000002068 genetic effect Effects 0.000 claims 36
- 108060003951 Immunoglobulin Proteins 0.000 claims 35
- 102000018358 immunoglobulin Human genes 0.000 claims 35
- 101000664600 Homo sapiens Tripartite motif-containing protein 3 Proteins 0.000 claims 25
- 102100038798 Tripartite motif-containing protein 3 Human genes 0.000 claims 25
- 235000018102 proteins Nutrition 0.000 claims 24
- 102000004169 proteins and genes Human genes 0.000 claims 24
- 108090000623 proteins and genes Proteins 0.000 claims 24
- 238000013518 transcription Methods 0.000 claims 8
- 230000035897 transcription Effects 0.000 claims 8
- 102100040881 60S acidic ribosomal protein P0 Human genes 0.000 claims 5
- 101000609814 Dictyostelium discoideum Protein disulfide-isomerase 1 Proteins 0.000 claims 5
- 101000673456 Homo sapiens 60S acidic ribosomal protein P0 Proteins 0.000 claims 5
- 101001114059 Homo sapiens Protein-arginine deiminase type-1 Proteins 0.000 claims 5
- 102100023222 Protein-arginine deiminase type-1 Human genes 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 5
- 210000000349 chromosome Anatomy 0.000 claims 4
- 241000235058 Komagataella pastoris Species 0.000 claims 2
- 102000007562 Serum Albumin Human genes 0.000 claims 2
- 108010071390 Serum Albumin Proteins 0.000 claims 2
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 1
- 102000008100 Human Serum Albumin Human genes 0.000 claims 1
- 108091006905 Human Serum Albumin Proteins 0.000 claims 1
- -1 Kar2p Proteins 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 230000001276 controlling effect Effects 0.000 claims 1
- 230000002596 correlated effect Effects 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662294470P | 2016-02-12 | 2016-02-12 | |
| US62/294,470 | 2016-02-12 | ||
| JP2018542263A JP7540877B2 (ja) | 2016-02-12 | 2017-02-10 | 免疫グロブリン単一可変ドメインの生成方法 |
| PCT/EP2017/053034 WO2017137579A1 (en) | 2016-02-12 | 2017-02-10 | Method for the production of immunoglobulin single variable domains |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018542263A Division JP7540877B2 (ja) | 2016-02-12 | 2017-02-10 | 免疫グロブリン単一可変ドメインの生成方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024073531A JP2024073531A (ja) | 2024-05-29 |
| JP2024073531A5 true JP2024073531A5 (enExample) | 2024-11-11 |
Family
ID=58018106
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018542263A Active JP7540877B2 (ja) | 2016-02-12 | 2017-02-10 | 免疫グロブリン単一可変ドメインの生成方法 |
| JP2024038103A Pending JP2024073531A (ja) | 2016-02-12 | 2024-03-12 | 免疫グロブリン単一可変ドメインの生成方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018542263A Active JP7540877B2 (ja) | 2016-02-12 | 2017-02-10 | 免疫グロブリン単一可変ドメインの生成方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10975141B2 (enExample) |
| EP (1) | EP3414268A1 (enExample) |
| JP (2) | JP7540877B2 (enExample) |
| CN (1) | CN108699151B (enExample) |
| AU (2) | AU2017216864B2 (enExample) |
| CA (1) | CA3014443A1 (enExample) |
| WO (1) | WO2017137579A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO2768984T3 (enExample) * | 2015-11-12 | 2018-06-09 | ||
| EP3414268A1 (en) | 2016-02-12 | 2018-12-19 | Ablynx NV | Method for the production of immunoglobulin single variable domains |
| WO2019187911A1 (ja) * | 2018-03-26 | 2019-10-03 | 国立大学法人神戸大学 | 新規細胞及びそれを用いた目的タンパク質の製造方法 |
| CN114981300B (zh) * | 2019-12-06 | 2025-10-31 | 艾伯霖克斯公司 | 包含靶向TNFα和IL-23的免疫球蛋白单个可变结构域的多肽 |
| CN110964113B (zh) * | 2019-12-24 | 2021-09-03 | 北京纽安博生物技术有限公司 | 介导结合免疫球蛋白的单域抗体、由其构建的双功能抗体及其应用 |
| WO2021187560A1 (ja) * | 2020-03-19 | 2021-09-23 | 国立大学法人神戸大学 | 内在性遺伝子の発現が増強された遺伝子組換え細胞の製造方法 |
| EP4126971A1 (en) | 2020-03-30 | 2023-02-08 | Ablynx N.V. | Method for the production and purification of multivalent immunoglobulin single variable domains |
| FR3120866B1 (fr) | 2021-03-19 | 2025-02-28 | Univ Toulouse 3 Paul Sabatier | Molécule hybride comprenant un peptide citrulliné dérivé de la fibrine et un anticorps ou fragment d’anticorps se liant à CD38 et/ou CD138, et ses utilisations |
| FR3120877B1 (fr) | 2021-03-19 | 2025-03-14 | Univ Toulouse 3 Paul Sabatier | Cellule immunitaire comprenant un récepteur Fc à sa surface, et sur lequel est greffé une molécule hybride comprenant un fragment Fc d’anticorps et au moins un peptide citrulliné dérivé de la fibrine, et ses utilisations |
| FR3120865B1 (fr) | 2021-03-19 | 2025-02-28 | Univ Toulouse 3 Paul Sabatier | Molécule hybride comprenant un fragment Fc d’anticorps et au moins un peptide citrulliné dérivé de la fibrine, et ses utilisations |
| CN114920839B (zh) * | 2022-06-17 | 2023-03-10 | 天津大学 | 特异性结合il-23的纳米抗体及其用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8232377B2 (en) | 2006-05-16 | 2012-07-31 | National Institute Of Advanced Industrial Science And Technology | Method for high-level secretory production of protein |
| US9212226B2 (en) | 2008-05-16 | 2015-12-15 | Ablynx N.V. | Amino acid sequences directed against CXCR4 and other GPCRs and compounds comprising the same |
| DK2982690T3 (da) | 2009-04-30 | 2021-04-12 | Ablynx Nv | Fremgangsmåde til fremstilling af domæne-antistoffer |
| WO2010135678A1 (en) * | 2009-05-22 | 2010-11-25 | Research Corporation Technologies, Inc. | Nucleic acids of pichia pastoris and use thereof for recombinant production of proteins |
| WO2011161266A1 (en) | 2010-06-25 | 2011-12-29 | Ablynx Nv | Improved immunoglobulin single variable domains and constructs thereof directed against cxcr4 |
| US20150158948A9 (en) | 2011-03-28 | 2015-06-11 | Francis Descamps | Bispecific anti-cxcr7 immunoglobulin single variable domains |
| PT3248986T (pt) | 2014-05-16 | 2022-04-05 | Ablynx Nv | Domínios variáveis de imunoglobulina |
| EP3414268A1 (en) | 2016-02-12 | 2018-12-19 | Ablynx NV | Method for the production of immunoglobulin single variable domains |
-
2017
- 2017-02-10 EP EP17704752.9A patent/EP3414268A1/en active Pending
- 2017-02-10 AU AU2017216864A patent/AU2017216864B2/en active Active
- 2017-02-10 WO PCT/EP2017/053034 patent/WO2017137579A1/en not_active Ceased
- 2017-02-10 JP JP2018542263A patent/JP7540877B2/ja active Active
- 2017-02-10 US US16/076,314 patent/US10975141B2/en active Active
- 2017-02-10 CA CA3014443A patent/CA3014443A1/en active Pending
- 2017-02-10 CN CN201780010990.9A patent/CN108699151B/zh active Active
-
2020
- 2020-07-30 US US16/943,022 patent/US11851480B2/en active Active
-
2023
- 2023-09-19 AU AU2023233070A patent/AU2023233070A1/en not_active Abandoned
-
2024
- 2024-03-12 JP JP2024038103A patent/JP2024073531A/ja active Pending
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