CA3014443A1 - Method for the production of immunoglobulin single variable domains - Google Patents
Method for the production of immunoglobulin single variable domains Download PDFInfo
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- CA3014443A1 CA3014443A1 CA3014443A CA3014443A CA3014443A1 CA 3014443 A1 CA3014443 A1 CA 3014443A1 CA 3014443 A CA3014443 A CA 3014443A CA 3014443 A CA3014443 A CA 3014443A CA 3014443 A1 CA3014443 A1 CA 3014443A1
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- nucleic acid
- polypeptide
- single variable
- immunoglobulin single
- variable domain
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662294470P | 2016-02-12 | 2016-02-12 | |
| US62/294,470 | 2016-02-12 | ||
| PCT/EP2017/053034 WO2017137579A1 (en) | 2016-02-12 | 2017-02-10 | Method for the production of immunoglobulin single variable domains |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3014443A1 true CA3014443A1 (en) | 2017-08-17 |
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ID=58018106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3014443A Pending CA3014443A1 (en) | 2016-02-12 | 2017-02-10 | Method for the production of immunoglobulin single variable domains |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10975141B2 (enExample) |
| EP (1) | EP3414268A1 (enExample) |
| JP (2) | JP7540877B2 (enExample) |
| CN (1) | CN108699151B (enExample) |
| AU (2) | AU2017216864B2 (enExample) |
| CA (1) | CA3014443A1 (enExample) |
| WO (1) | WO2017137579A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO2768984T3 (enExample) * | 2015-11-12 | 2018-06-09 | ||
| EP3414268A1 (en) | 2016-02-12 | 2018-12-19 | Ablynx NV | Method for the production of immunoglobulin single variable domains |
| WO2019187911A1 (ja) * | 2018-03-26 | 2019-10-03 | 国立大学法人神戸大学 | 新規細胞及びそれを用いた目的タンパク質の製造方法 |
| CN114981300B (zh) * | 2019-12-06 | 2025-10-31 | 艾伯霖克斯公司 | 包含靶向TNFα和IL-23的免疫球蛋白单个可变结构域的多肽 |
| CN110964113B (zh) * | 2019-12-24 | 2021-09-03 | 北京纽安博生物技术有限公司 | 介导结合免疫球蛋白的单域抗体、由其构建的双功能抗体及其应用 |
| WO2021187560A1 (ja) * | 2020-03-19 | 2021-09-23 | 国立大学法人神戸大学 | 内在性遺伝子の発現が増強された遺伝子組換え細胞の製造方法 |
| EP4126971A1 (en) | 2020-03-30 | 2023-02-08 | Ablynx N.V. | Method for the production and purification of multivalent immunoglobulin single variable domains |
| FR3120866B1 (fr) | 2021-03-19 | 2025-02-28 | Univ Toulouse 3 Paul Sabatier | Molécule hybride comprenant un peptide citrulliné dérivé de la fibrine et un anticorps ou fragment d’anticorps se liant à CD38 et/ou CD138, et ses utilisations |
| FR3120877B1 (fr) | 2021-03-19 | 2025-03-14 | Univ Toulouse 3 Paul Sabatier | Cellule immunitaire comprenant un récepteur Fc à sa surface, et sur lequel est greffé une molécule hybride comprenant un fragment Fc d’anticorps et au moins un peptide citrulliné dérivé de la fibrine, et ses utilisations |
| FR3120865B1 (fr) | 2021-03-19 | 2025-02-28 | Univ Toulouse 3 Paul Sabatier | Molécule hybride comprenant un fragment Fc d’anticorps et au moins un peptide citrulliné dérivé de la fibrine, et ses utilisations |
| CN114920839B (zh) * | 2022-06-17 | 2023-03-10 | 天津大学 | 特异性结合il-23的纳米抗体及其用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8232377B2 (en) | 2006-05-16 | 2012-07-31 | National Institute Of Advanced Industrial Science And Technology | Method for high-level secretory production of protein |
| US9212226B2 (en) | 2008-05-16 | 2015-12-15 | Ablynx N.V. | Amino acid sequences directed against CXCR4 and other GPCRs and compounds comprising the same |
| DK2982690T3 (da) | 2009-04-30 | 2021-04-12 | Ablynx Nv | Fremgangsmåde til fremstilling af domæne-antistoffer |
| WO2010135678A1 (en) * | 2009-05-22 | 2010-11-25 | Research Corporation Technologies, Inc. | Nucleic acids of pichia pastoris and use thereof for recombinant production of proteins |
| WO2011161266A1 (en) | 2010-06-25 | 2011-12-29 | Ablynx Nv | Improved immunoglobulin single variable domains and constructs thereof directed against cxcr4 |
| US20150158948A9 (en) | 2011-03-28 | 2015-06-11 | Francis Descamps | Bispecific anti-cxcr7 immunoglobulin single variable domains |
| PT3248986T (pt) | 2014-05-16 | 2022-04-05 | Ablynx Nv | Domínios variáveis de imunoglobulina |
| EP3414268A1 (en) | 2016-02-12 | 2018-12-19 | Ablynx NV | Method for the production of immunoglobulin single variable domains |
-
2017
- 2017-02-10 EP EP17704752.9A patent/EP3414268A1/en active Pending
- 2017-02-10 AU AU2017216864A patent/AU2017216864B2/en active Active
- 2017-02-10 WO PCT/EP2017/053034 patent/WO2017137579A1/en not_active Ceased
- 2017-02-10 JP JP2018542263A patent/JP7540877B2/ja active Active
- 2017-02-10 US US16/076,314 patent/US10975141B2/en active Active
- 2017-02-10 CA CA3014443A patent/CA3014443A1/en active Pending
- 2017-02-10 CN CN201780010990.9A patent/CN108699151B/zh active Active
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2020
- 2020-07-30 US US16/943,022 patent/US11851480B2/en active Active
-
2023
- 2023-09-19 AU AU2023233070A patent/AU2023233070A1/en not_active Abandoned
-
2024
- 2024-03-12 JP JP2024038103A patent/JP2024073531A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2017216864A1 (en) | 2018-07-26 |
| WO2017137579A1 (en) | 2017-08-17 |
| CN108699151B (zh) | 2022-08-12 |
| JP2019507748A (ja) | 2019-03-22 |
| AU2023233070A1 (en) | 2023-10-05 |
| US11851480B2 (en) | 2023-12-26 |
| US20210047392A1 (en) | 2021-02-18 |
| EP3414268A1 (en) | 2018-12-19 |
| CN108699151A (zh) | 2018-10-23 |
| JP2024073531A (ja) | 2024-05-29 |
| AU2017216864B2 (en) | 2023-06-22 |
| JP7540877B2 (ja) | 2024-08-27 |
| US10975141B2 (en) | 2021-04-13 |
| US20190194302A1 (en) | 2019-06-27 |
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