JP2024026132A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2024026132A5 JP2024026132A5 JP2023197481A JP2023197481A JP2024026132A5 JP 2024026132 A5 JP2024026132 A5 JP 2024026132A5 JP 2023197481 A JP2023197481 A JP 2023197481A JP 2023197481 A JP2023197481 A JP 2023197481A JP 2024026132 A5 JP2024026132 A5 JP 2024026132A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- cancer
- antigen
- binding fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000427 antigen Substances 0.000 claims 12
- 102000036639 antigens Human genes 0.000 claims 12
- 108091007433 antigens Proteins 0.000 claims 12
- 239000012634 fragment Substances 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 2
- 102000053602 DNA Human genes 0.000 claims 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 241000699802 Cricetulus griseus Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 241000235648 Pichia Species 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 229940039227 diagnostic agent Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 201000010175 gallbladder cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810142118 | 2018-02-11 | ||
| CN201810142118.6 | 2018-02-11 | ||
| PCT/CN2019/074397 WO2019154315A1 (zh) | 2018-02-11 | 2019-02-01 | 抗b7-h4抗体、其抗原结合片段及其医药用途 |
| JP2020542138A JP7393337B2 (ja) | 2018-02-11 | 2019-02-01 | 抗ｂ７－ｈ４抗体、その抗原結合断片及びその医薬用途 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020542138A Division JP7393337B2 (ja) | 2018-02-11 | 2019-02-01 | 抗ｂ７－ｈ４抗体、その抗原結合断片及びその医薬用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024026132A JP2024026132A (ja) | 2024-02-28 |
| JP2024026132A5 true JP2024026132A5 (enExample) | 2024-03-15 |
Family
ID=67548182
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020542138A Active JP7393337B2 (ja) | 2018-02-11 | 2019-02-01 | 抗ｂ７－ｈ４抗体、その抗原結合断片及びその医薬用途 |
| JP2023197481A Pending JP2024026132A (ja) | 2018-02-11 | 2023-11-21 | 抗ｂ７－ｈ４抗体、その抗原結合断片及びその医薬用途 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020542138A Active JP7393337B2 (ja) | 2018-02-11 | 2019-02-01 | 抗ｂ７－ｈ４抗体、その抗原結合断片及びその医薬用途 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11472882B2 (enExample) |
| EP (1) | EP3753951A4 (enExample) |
| JP (2) | JP7393337B2 (enExample) |
| KR (1) | KR20200119846A (enExample) |
| CN (2) | CN116693686A (enExample) |
| AU (1) | AU2019218319B2 (enExample) |
| BR (1) | BR112020015736A2 (enExample) |
| CA (1) | CA3089246A1 (enExample) |
| MX (1) | MX2020008181A (enExample) |
| TW (1) | TWI823895B (enExample) |
| WO (1) | WO2019154315A1 (enExample) |
| ZA (1) | ZA202004701B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200119846A (ko) * | 2018-02-11 | 2020-10-20 | 장쑤 한서 파마슈티칼 그룹 캄파니 리미티드 | 항 비7 에이치4 항체, 그의 항원 결합 단편 및 그의 약학적 용도 |
| CN112351797B (zh) * | 2019-06-06 | 2023-12-22 | 上海翰森生物医药科技有限公司 | 抗b7-h4抗体-药物偶联物及其医药用途 |
| WO2021190480A1 (zh) * | 2020-03-24 | 2021-09-30 | 上海翰森生物医药科技有限公司 | 抗体-药物偶联物及其医药用途 |
| TW202144425A (zh) * | 2020-04-17 | 2021-12-01 | 大陸商上海翰森生物醫藥科技有限公司 | 特異性抗原結合分子，其製備方法及醫藥用途 |
| CN116249717A (zh) | 2020-06-24 | 2023-06-09 | 普罗塞纳生物科学有限公司 | 识别分拣蛋白的抗体 |
| WO2022039490A1 (en) * | 2020-08-18 | 2022-02-24 | Abl Bio, Inc. | Anti-b7-h4/anti-4-1bb bispecific antibodies and use thereof |
| CA3203721A1 (en) | 2021-01-04 | 2022-07-07 | Timothy B. Lowinger | B7h4-targeted antibody-drug conjugates and methods of use thereof |
| IL305847A (en) | 2021-03-26 | 2023-11-01 | Innate Pharma | Multispecific proteins that contain a binding site for NKP46, a binding site for a cancer antigen that is fused to a cytokine to attract NK cells |
| WO2022258678A1 (en) | 2021-06-09 | 2022-12-15 | Innate Pharma | Multispecific proteins binding to nkp30, a cytokine receptor, a tumour antigen and cd16a |
| WO2022258691A1 (en) | 2021-06-09 | 2022-12-15 | Innate Pharma | Multispecific proteins binding to nkg2d, a cytokine receptor, a tumour antigen and cd16a |
| WO2022258662A1 (en) | 2021-06-09 | 2022-12-15 | Innate Pharma | Multispecific proteins binding to nkp46, a cytokine receptor, a tumour antigen and cd16a |
| US20240309095A1 (en) * | 2021-07-07 | 2024-09-19 | Incyte Corporation | Anti-b7-h4 antibodies and uses thereof |
| AU2022402985A1 (en) * | 2021-12-01 | 2024-07-11 | Kadmon Corporation, Llc | B7-h4 antibodies and anti-b7-h4 antibody/il-15 fusion proteins |
| CA3242070A1 (en) * | 2021-12-23 | 2023-06-29 | Andriani IOANNOU | Antibodies recognizing sortilin |
| IL315698A (en) * | 2022-03-30 | 2024-11-01 | Duality Biologics Suzhou Co Ltd | B7h4 antibody-drug conjugate and use thereof |
| WO2024208818A1 (en) | 2023-04-04 | 2024-10-10 | Innate Pharma | Modular chimeric antigen receptor |
| TW202444431A (zh) * | 2023-04-12 | 2024-11-16 | 大陸商上海翰森生物醫藥科技有限公司 | 抗體藥物偶聯物在製備預防和／或治療癌症的藥物中的用途 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030091580A1 (en) * | 2001-06-18 | 2003-05-15 | Mitcham Jennifer L. | Compositions and methods for the therapy and diagnosis of ovarian cancer |
| US6858710B2 (en) * | 1998-12-17 | 2005-02-22 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of ovarian cancer |
| EP3058955B1 (en) * | 2005-03-24 | 2019-05-29 | Millennium Pharmaceuticals, Inc. | Antibodies that bind ov064 and methods of use therefor |
| US8759490B2 (en) * | 2005-03-24 | 2014-06-24 | Millennium Pharamaceuticals, Inc. | Antibodies that bind OV064 and methods of use therefor |
| CN104072614B (zh) * | 2005-07-08 | 2017-04-26 | 生物基因Ma公司 | 抗-αvβ6 抗体及其用途 |
| WO2009073533A2 (en) * | 2007-11-30 | 2009-06-11 | Medarex, Inc. | Anti-b7h4 monoclonal antibody-drug conjugate and methods of use |
| PT3042917T (pt) * | 2010-08-12 | 2018-05-02 | Lilly Co Eli | Anticorpos do péptido beta amilóide anti-n3pglu e seus usos |
| CA2845536A1 (en) | 2011-08-15 | 2013-02-21 | Amplimmune, Inc. | Anti-b7-h4 antibodies and their uses |
| WO2013157105A1 (ja) * | 2012-04-18 | 2013-10-24 | 公立大学法人大阪市立大学 | ムチンサブタイプ５ａｃ特異的ヒト化抗体およびその利用 |
| SG11201504764SA (en) * | 2012-12-19 | 2015-07-30 | Amplimmune Inc | Anti-human b7-h4 antibodies and their uses |
| AU2014244424A1 (en) * | 2013-03-14 | 2015-08-27 | Genentech, Inc. | Anti-B7-H4 antibodies and immunoconjugates |
| US9562099B2 (en) | 2013-03-14 | 2017-02-07 | Genentech, Inc. | Anti-B7-H4 antibodies and immunoconjugates |
| CN103981150B (zh) * | 2014-03-28 | 2016-06-01 | 苏州大学 | 抗人b7-h4单克隆抗体及其制备和应用 |
| EP3191518B1 (en) * | 2014-09-12 | 2020-01-15 | Genentech, Inc. | Anti-b7-h4 antibodies and immunoconjugates |
| CA2981143A1 (en) * | 2015-03-27 | 2016-10-06 | University Of Southern California | Car t-cells for the treatment of b7-h4 expressing solid tumors |
| US11433141B2 (en) * | 2016-07-26 | 2022-09-06 | Shizuoka Prefecture | Anti-B7-H4 antibody |
| CN107299085B (zh) * | 2017-05-26 | 2020-09-29 | 广东医科大学 | 分泌抗人b7-h4胞外单克隆抗体杂交瘤细胞株和抗人b7-h4单克隆抗体及其应用 |
| KR20200119846A (ko) * | 2018-02-11 | 2020-10-20 | 장쑤 한서 파마슈티칼 그룹 캄파니 리미티드 | 항 비7 에이치4 항체, 그의 항원 결합 단편 및 그의 약학적 용도 |
| AU2019228600A1 (en) * | 2018-03-02 | 2020-09-24 | Five Prime Therapeutics, Inc. | B7-H4 antibodies and methods of use thereof |
| KR102227515B1 (ko) | 2018-12-18 | 2021-03-12 | 주식회사 포스코 | 제올라이트 및 그 제조방법 |
-
2019
- 2019-02-01 KR KR1020207026012A patent/KR20200119846A/ko active Pending
- 2019-02-01 US US16/967,016 patent/US11472882B2/en active Active
- 2019-02-01 BR BR112020015736-8A patent/BR112020015736A2/pt unknown
- 2019-02-01 CA CA3089246A patent/CA3089246A1/en active Pending
- 2019-02-01 AU AU2019218319A patent/AU2019218319B2/en active Active
- 2019-02-01 JP JP2020542138A patent/JP7393337B2/ja active Active
- 2019-02-01 CN CN202310820681.5A patent/CN116693686A/zh active Pending
- 2019-02-01 EP EP19750949.0A patent/EP3753951A4/en active Pending
- 2019-02-01 MX MX2020008181A patent/MX2020008181A/es unknown
- 2019-02-01 CN CN201980001361.9A patent/CN110366560B/zh active Active
- 2019-02-01 WO PCT/CN2019/074397 patent/WO2019154315A1/zh not_active Ceased
- 2019-02-11 TW TW108104453A patent/TWI823895B/zh active
-
2020
- 2020-07-29 ZA ZA2020/04701A patent/ZA202004701B/en unknown
-
2023
- 2023-11-21 JP JP2023197481A patent/JP2024026132A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024026132A5 (enExample) | ||
| EP3368572B9 (en) | Anti-pd-1 antibodies and compositions | |
| CN107151269B (zh) | 一种pdl-1抗体、其药物组合物及其用途 | |
| JP6205410B2 (ja) | Ｓｔ２抗原結合タンパク質 | |
| RU2020127196A (ru) | Антитело против 4-1bb, его антигенсвязывающий фрагмент и его медицинское применение | |
| RU2018119165A (ru) | Антитело против лиганда 1 запрограммированной гибели клеток (pd-l1), его антигенсвязывающий фрагмент и их медицинское применение | |
| CN109843927A (zh) | 抗b7-h3抗体、其抗原结合片段及其医药用途 | |
| JP2020522280A5 (enExample) | ||
| WO2014194274A2 (en) | Oncostatin m receptor antigen binding proteins | |
| US20250179195A1 (en) | Anti-flt3 antibodies and compositions | |
| JP2020522281A5 (enExample) | ||
| US20250051467A1 (en) | Fap/cd40 binding molecule and medicinal use thereof | |
| CN114901697A (zh) | 一种抗lag-3的单克隆抗体、其抗原结合片段及其应用 | |
| US20210189003A1 (en) | De-immunised anti-erbb3 antibodies | |
| US11655300B2 (en) | Colony stimulating factor 1 receptor (CSF1R) antibodies and immunoconjugates thereof | |
| US12030942B2 (en) | Anti-PD-1 antibodies and compositions | |
| WO2024131846A1 (en) | Antibody, antigen-binding fragment thereof, and pharmaceutical use thereof | |
| RU2836004C1 (ru) | Антитела и композиции против flt3 | |
| RU2020124155A (ru) | Антитело к b7-h4, его антигенсвязывающий фрагмент и его фармацевтическое применение | |
| HK40085294A (en) | Anti-pd-1 antibodies and compositions | |
| WO2024183791A1 (zh) | 包含抗ctla4-抗pd-1双特异性抗体的药物组合及其用途 | |
| TW202521578A (zh) | Ｂｔｎ３ａ結合蛋白及其醫藥用途 | |
| RU2021116840A (ru) | Антитело против cd40, его антигенсвязывающий фрагмент и фармацевтическое применение | |
| JPWO2022242680A5 (enExample) | ||
| RU2019141751A (ru) | Антитело к cd40, его антигенсвязывающий фрагмент и его медицинское применение |