JP2024017078A - Muscle water content improving agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an agent that can improve muscle water content.

SOLUTION: Boi-ogi-to extract can increase muscle water content and is therefore suitable as a muscle water content improving agent.

SELECTED DRAWING: None

COPYRIGHT: (C)2024,JPO&INPIT

Description

The present invention relates to an agent for improving muscle water content.

43.4% of the water in the entire body is present in muscles, and muscle tissue contains as much as 76% water (Non-Patent Document 1).

Fluctuations in the amount of water in the body due to a decrease in muscle mass or water content in the muscles have various adverse effects on biological reactions. Such examples include heat stroke (Non-patent Document 2), decreased endurance performance and sprint performance during exercise (Non-patent Document 3), cerebral infarction, myocardial infarction, hypotension symptoms, immunodeficiency, etc. (Non-patent Document 3), etc. 4).

Air conditioning and sanitary engineering 1979 53 (7) p.617-622 Heatstroke Environmental Health Manual 2008, Ministry of the Environment Heat countermeasure guidebook for athletes, 2017, Japan Sports Promotion Center, National Sports Science Center “It is said that the human body is 60-70% water, but where in the body does it contain the most water?”, [online], October 31, 2017, Insurance Clinic Yokohama Bay Life Service Co., Ltd., [searched on July 22, 2020], Internet <URL: https://www.hoken119.co.jp/info/qa/%E4%BA%BA%E9%96%93%E3% 81%AE%E4%BD%93%E3%81%AF60%EF%BD%9E70%EF%BC%85%E3%81%8C%E6%B0%B4%E5%88%86%E3%81% A8%E8%A8%80%E3%82%8F%E3%82%8C%E3%81%A6%E3%81%84%E3%81%BE%E3%81%99%E3%81%8C% E3%80%81%E6%9C%80/＞

The quickest way to increase the amount of water in your body is to increase the amount of muscle that stores water. However, it is not easy to increase muscle mass, and it is especially difficult for women and the elderly because their muscle mass tends to decrease. If we can increase the amount of water in our muscles, even people with little muscle mass can expect to improve their body water content, which is equivalent to increasing muscle mass.

Therefore, an object of the present invention is to provide a drug that can improve muscle water content.

As a result of intensive studies, the inventors of the present invention have discovered that Hobakokito extract has the effect of improving muscle water content. The present invention was completed through further studies based on this knowledge.

That is, the present invention provides the inventions of the following aspects.
Item 1. A muscle water content improving agent containing Hokiokito extract.
Item 2. Item 1. The muscle water content improving agent according to item 1, which is applied to women after menopause.

According to the present invention, a drug capable of improving muscle water content is provided.

Demonstrates the effect of Hokiokito extract on improving muscle water content.

The present invention is characterized in that it contains Bokkito extract and is used as a muscle water content improving agent. Hereinafter, the muscle water content improving agent of the present invention will be explained in detail.

As for the active ingredient Hobaokito, it is preferable to use the Chinese herbal prescriptions listed in the "New General Chinese Herbal Prescription Guide" (supervised by Yukihiro Goda and Takashi Hakamazuka, edited by the Japan Traditional Chinese Herbal Medicine Preparation Association, published by Jiho Co., Ltd.). Examples include mixed herbal medicines consisting of , Aspergillus japonica , Jutsu (includes Sandalwood jutsu and Sojutsu , preferably Sandalwood jutsu is mentioned), Gingerbread, Astragalus, and Licorice. In addition, Bokiokito contains the mixtures listed in the letters related to herbal medicines that are currently frequently used, as stipulated in the "Basic Handling Policy for Chinese Herbal Preparations" established by the Kampo Herbal Medicine Investigation Committee. Includes crude drugs (Chinese herbal prescriptions).

The Bokiokito extract in the present invention may be obtained as an extract liquid by extracting the above-mentioned mixed herbal medicine and concentrating the obtained extract liquid as necessary, or by drying the extract liquid. It can also be obtained as an extract powder.

In the production of Hoba Okito extract, the extraction solvent used in the extraction process is not particularly limited, but water or aqueous ethanol can be mentioned as an example. The drying process is not particularly limited, and may be performed using a known method such as spray drying, or by adding an appropriate adsorbent (for example, silicic anhydride, starch, etc.) to a soft extract with increased concentration of the extract liquid. Examples include a method of making an adsorbed powder.

As the Bokkito extract used in the present invention, an extract prepared by the method described above may be used, or a commercially available extract may be used. For example, as the extract powder of Hoki-o-kito, Bo-ki-o-ki-to dry extract A and Hoki-oki-to dry extract AZ (both manufactured by Nippon Powder Co., Ltd.), Boki-oki-to extract powder and Hoki-oki-to dry extract AZ are available. Bōkito Dry Extract-F (all manufactured by Alps Yakuhin Kogyo Co., Ltd.) and the like are known as commercial products and can also be obtained commercially.

In the muscle water content improving agent of the present invention, the content of the Hobaokito extract is not particularly limited as long as the effects of the present invention are achieved, but examples include, for example, 1 to 100% by weight in terms of dry extract amount. The term "converted amount of dry extract" refers to the amount itself when using a dry extract (extract powder), and when using an extract liquid or soft extract, it refers to the amount converted to the remaining amount after removing the solvent. Moreover, when the dry extract powder contains additives such as adsorbents added during production, the amount is the amount excluding the additives.

Other Ingredients The muscle water content improving agent of the present invention may consist of the Hobakokito extract alone, or may contain additives and bases depending on the formulation form. Such additives and bases are not particularly limited as long as they are pharmaceutically acceptable, but include, for example, excipients, binders, disintegrants, lubricants, tonicity agents, plasticizers, Dispersants, emulsifiers, solubilizing agents, wetting agents, stabilizers, suspending agents, adhesives, coating agents, brightening agents, water, oils and fats, waxes, hydrocarbons, fatty acids, higher alcohols , esters, water-soluble polymers, surfactants, metal soaps, lower alcohols, polyhydric alcohols, pH adjusters, buffers, antioxidants, ultraviolet inhibitors, preservatives, flavorings, fragrances, powders, Examples include thickeners, dyes, chelating agents, and the like. These additives may be used alone or in combination of two or more. Further, the contents of these additives and bases are appropriately set depending on the types of additives and bases used, the formulation form of the muscle water content improving agent, and the like.

The muscle water content improving agent of the present invention may contain other pharmacological ingredients in addition to the Hobaokito extract, if necessary. The types of such pharmacological ingredients are not particularly limited, but include, for example, antacids, stomachic agents, digestive agents, intestinal regulators, antispasmodics, mucosal repair agents, anti-inflammatory agents, astringents, antiemetics, antitussives, expectorants, and anti-inflammatory agents. Enzymes, sedative-hypnotics, antihistamines, caffeine, cardiotonic diuretics, antibacterial agents, vasoconstrictors, vasodilators, local anesthetics, herbal medicines, herbal extract powders, vitamins, menthol, etc. These pharmacological ingredients may be used alone or in combination of two or more. Moreover, the content of these pharmacological components may be appropriately set from known ones depending on the type of pharmacological components to be used.

Formulation Form The form of formulation of the muscle water content improving agent of the present invention is not particularly limited as long as it can be administered orally, but examples include powders, fine granules, granules (including dry syrup), tablets, and pills. Examples include solid preparations such as tablets and capsules (soft capsules and hard capsules); semi-solid preparations such as jellies; and liquid preparations such as solutions, suspensions, and syrups. Among these formulation forms, solid formulations are preferred from the viewpoints of stability of contained ingredients, portability, and the like.

In order to prepare the muscle water content improving agent of the present invention into the above-mentioned formulation form, Bokiokito extract and additives, bases, and pharmacological ingredients added as necessary are used in the pharmaceutical field. It may be formulated according to the conventional formulation method.

Applications The muscle water content improving agent of the present invention can be used for any purpose as long as it is used for the purpose of improving muscle water content. Improving muscle water content refers to increasing the reduced muscle water content to a normal amount or an amount exceeding the normal amount. More specifically, the muscle water content improving agent of the present invention utilizes the muscle water content improving effect to suppress or suppress a decrease in water content associated with a decrease in muscle mass or symptoms based on a decrease in muscle water content. It can be used for improvement purposes. More specifically, the muscle water content improving agent of the present invention can prevent or improve heatstroke, prevent or improve endurance performance during exercise or decrease in sprint performance, cerebral infarction, myocardial infarction, hypotension symptoms, immunity. Examples include prevention or improvement of health disorders such as poor health.

Since the muscle water content improving agent of the present invention has the effect of increasing muscle water content, it is preferably applied to subjects with a small amount of muscle, which is a water storage reservoir. Such subjects include people who are aware of lack of exercise, women, elderly people, etc. Among them, women who are after menopause are preferred.

Dose/Administration The muscle water content improving agent of the present invention is administered orally. The dosage of the muscle water content improving agent of the present invention is appropriately determined depending on the symptoms, age, etc. of the subject. For example, the daily intake amount of Hoba Okito extract in terms of dry extract amount is 1,300 to 6,000 mg, preferably 2,000 to 4,800 mg, and more preferably 3,000 to 4,000 mg.

The timing of taking the muscle water content improving agent of the present invention is not particularly limited, and may be taken before meals, after meals, or between meals, but preferably before meals or between meals.

EXAMPLES Hereinafter, the present invention will be specifically explained with reference to Examples, but the present invention is not limited to these Examples.

As a raw material crude drug for the preparation of BOT extract powder , 1 part by weight of ginger, 3 parts by weight, 5 parts by weight, 3 parts byakujutsu, 5 parts by weight, and 1.5 parts by weight of licorice were used. After chopping, it was extracted at about 100°C for 1 hour using 20 times the weight of water, centrifuged to obtain an extract, concentrated under reduced pressure, and dried using a spray dryer to obtain Boba Okeito extract powder. I got it. Note that drying with a spray dryer was performed by dropping the extract into an atomizer with a rotational speed of 10,000 rpm, and supplying hot air at 150°C.

Experimental method Using female C57BL/6J mice, two ovariectomized groups (OVX) and one sham-operated group (Sham) were created at the age of 6 weeks, and they were fed normal food and underwent a 2-week recovery period. Afterwards, they were fed a high-fat diet for an additional two weeks. The high-fat diet fed to one of the two OVX groups (this will be referred to as the OVX-BOT group) contained 2% by weight of Bobaokito (BOT) extract powder.

Thereafter, the calf muscle was extracted and its weight (wet weight) was measured. Furthermore, the extracted calf muscles were freeze-dried and dried until they reached a constant weight. After drying, the weight (dry weight) was measured again, and the ratio (%) of the water content to the dry weight obtained by subtracting the dry weight from the wet weight was derived as the muscle water content. The results are shown in Figure 1.

Results As shown in Figure 1, it was observed that muscle water content significantly increased in the OVX-BOT group. In other words, it was confirmed that Hobakokito extract has an excellent effect on improving muscle water content.

Claims (2)

A muscle water content improving agent containing Hokiokito extract. The muscle water content improving agent according to claim 1, which is applied to women after menopause.