JP2024029735A - Medicine for alleviating health issues caused by crowds - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an oral medicine that can alleviate health issues caused by crowds.

SOLUTION: A medicine for alleviating health issues caused by crowds comprises ryokei-jutsukan-to extract as an active ingredient.

SELECTED DRAWING: None

COPYRIGHT: (C)2024,JPO&INPIT

Description

TECHNICAL FIELD The present invention relates to a medicine for improving crowd disorder.

BACKGROUND ART Environments where people are densely packed (hereinafter referred to as "crowds"), such as crowded trains, downtown areas, and event venues, bring stimulation unique to the environment to people. Such stimuli induce various disorders in people who have characteristics such as high sensitivity.

Specifically, the stimuli brought about by a crowded environment include tension stimulation caused by others approaching one's personal space and, in some cases, even more others coming and going; Stimulation of visual field due to forced movement of eyes due to passing of people; Stimulation of sound and/or smell; Stimulation of oxygen deficiency due to thinning of oxygen concentration, etc. These stimuli unique to crowded environments can cause headaches, headaches, etc. It induces complaints such as dizziness, malaise, and/or fatigue (hereinafter referred to as "crowd complaints").

Usually, analgesics are used to treat headaches, and antidepressants are used to treat dizziness. Crowd disorder is a predictable disorder that is induced by certain conditions such as being in a crowded environment, so it would be desirable to have an effective medication. However, crowd disorder tends to cause a combination of multiple symptoms such as headache, dizziness, malaise, fatigue, etc., and conventional medications cannot be used to adequately treat the condition.

Some Chinese herbal medicines are used in the field of psychiatry; for example, in Non-Patent Document 1, there is a Chinese herbal medicine used for anxiety and depression called Shiba, which is used for symptoms such as persistent tension due to stress. Kokaryukotsu-oyaito, Shigyakusan, Yokukansan; Keishikaryukotsu-oyaito, which is used to treat irritability, anxiety, palpitations, etc. in the weak, is described, and Non-Patent Document 2 describes Kamikihito and Kamishoyosan are described to be used for symptoms such as dizziness, which are aggravated by sexual factors.

Phil Chinese Medicine 2018; 70: 3-8. Phil Chinese Medicine 2014; 47: 20-2.

Since herbal medicine is a multi-component system, compound effects can be expected by acting on multiple points of action on the living body. However, since herbal medicines are generally slow-acting and are used for the purpose of improving one's physical condition, they are not expected to be used casually to treat symptoms of overcrowding. In addition, as mentioned above, conventional medicines (Western medicine) are not sufficient to improve the condition of crowding.

Therefore, an object of the present invention is to provide an internal medicine that can improve crowd discomfort.

After conducting extensive research, the inventors of the present invention have newly discovered that Reikeijuakanto can improve the problem of crowding. The present invention was completed through further studies based on this knowledge.

That is, the present invention provides the inventions of the following aspects.
Item 1. An anti-crowd medicine that contains Reikeijuu Kanto extract.
Item 2. Item 2. The crowd-related disorder improving drug according to item 1, which is used to improve headache, dizziness, malaise, and/or fatigue induced in a crowded environment.
Item 3. Item 2. The drug for improving crowd discomfort according to item 1 or 2, which is used to improve discomfort induced by riding in a crowded vehicle.
Item 4. The crowd-related disorder improving drug according to any one of Items 1 to 3, which is taken within 6 hours of exposure to a crowded environment.

According to the present invention, an oral medicine that can improve crowd disorder is provided.

The medicine for improving crowd discomfort of the present disclosure is characterized in that it contains Reikeijukanto extract and is used for improving crowd anxiety. Hereinafter, the medicine for improving crowd disorder of the present disclosure will be described in detail. In this specification, a numerical range indicated by two numerical values and "~" includes the two numerical values as the lower limit and upper limit. For example, the expression 2 to 15% by weight means 2% by weight or more and 15% by weight or less.

The Chinese herbal prescription for Reikei-Shuu-Akanto Extract Reikei-Shuu-Akanto is based on the Chinese herbal medicines listed in the "New Guide to Prescribing Traditional Chinese Herbal Medicine" (supervised by Yukihiro Goda and Takashi Hakamazuka, edited by the Japan Traditional Chinese Medicine Preparation Association, published by Jiho Co., Ltd.). Prescriptions are preferred, and specific examples include mixed herbal medicines consisting of sagebrush, sandalwood (soujutsu is also acceptable), cinnamon bark, and licorice. Preferably, mixed herbal medicines consisting of sagebrush, sageum, keihi, and licorice are exemplified. In addition, Reikeikyukanto is a mixture of herbal medicines that are listed in letters related to herbal medicines that are currently in frequent use, as stipulated in the "Basic Handling Policy for Chinese Herbal Preparations" established by the Kampo Herbal Medicine Investigation Committee. (Chinese herbal prescriptions) are included.

In addition, the amounts of each crude drug constituting Reikeijukanto are 2 to 6 parts by weight, preferably 3 to 6 parts by weight; 1 to 4 parts by weight, preferably 2 to 3.5 parts by weight. Parts by weight: 1 to 4 parts by weight, preferably 2 to 4 parts by weight of cinnamon; 0.5 to 3 parts by weight, preferably 1 to 2 parts by weight of licorice.

Suitable examples of the crude drug formulation used in the production of the Reikeijukanto extract used in the present disclosure include 6 parts by weight of Bukryō, 3 parts by weight of sandalwood (preferably sojutsu), 4 parts by weight of cinnamon bark, and 2 parts by weight of licorice. Examples include parts by weight.

The form of the extract of Reikeijuakanto may be either a liquid extract such as a soft extract, or a solid dry extract powder.

A liquid extract of Reikeijuakanto can be obtained by extracting a mixed herbal medicine according to the recipe of Reikeijuakanto and concentrating the obtained extract as necessary. Moreover, the dried extract powder of Reikeijukanto can be obtained by drying the liquid extract.

In the production of the extract of Reikeijuakanto, the extraction solvent used in the extraction process is not particularly limited, and includes water and aqueous ethanol. The extraction process for Reikeijuakanto is not particularly limited, but for example, after extraction with an extraction solvent of about 5 to 15 times the total weight (in terms of dry weight) of the herbal medicines contained in Reikeijuakanto. , a method of concentrating to 1/2 volume and removing the solid content is obtained as a liquid extract of Reikeijukanto. Further, by subjecting this liquid extract to a drying treatment, a dry extract powder of Reikeijukanto can be obtained. The drying process is not particularly limited, and any known method may be used, such as spray drying or adding an appropriate adsorbent (for example, silicic anhydride, starch, etc.) to a soft extract with increased concentration. Examples include a method of making an adsorbed powder.

In the present disclosure, when an extract is used as Reikeijukanto, an extract prepared by the method described above may be used, or a commercially available extract may be used.

In the medicine for improving crowd disorder of the present disclosure, the content of Reikei-Kuan-to extract is not particularly limited as long as it achieves the effects of the present disclosure, but it is usually 5 to 100% by weight in terms of dry extract powder of Rei-Kei-Kuan-to extract. %, preferably 10 to 90% by weight, more preferably 20 to 80% by weight, still more preferably 30 to 70% by weight. In addition, in the present disclosure, the converted amount of dry extract powder of Reikeijuu Kanto is the amount itself when using the dry extract powder of Reikeijuu Kanto; In some cases, it is the amount converted to the remaining amount after removing the solvent. In addition, if the dried extract powder of Reikeijukanto contains additives such as adsorbents added during production, the amount is the amount excluding the additives.

Other Ingredients The medicine for improving crowd disorder of the present disclosure may consist of the Reikeikai Kanto extract alone, or may contain additives and/or bases depending on the formulation form. Such additives and bases are not particularly limited as long as they are pharmaceutically acceptable, but include, for example, excipients, binders, disintegrants, lubricants, tonicity agents, plasticizers, Dispersants, emulsifiers, solubilizing agents, wetting agents, stabilizers, suspending agents, adhesives, coating agents, brightening agents, water, oils and fats, waxes, hydrocarbons, fatty acids, higher alcohols , esters, water-soluble polymers, surfactants, metal soaps, lower alcohols, polyhydric alcohols, pH adjusters, buffers, antioxidants, ultraviolet inhibitors, preservatives, flavorings, fragrances, powders, Examples include thickeners, dyes, chelating agents, and the like. These additives may be used alone or in combination of two or more. Further, the contents of these additives and bases are appropriately set depending on the types of additives and bases used, the formulation form of the crowd-congestion disorder improving drug, and the like.

In addition, the medicine for improving crowd disorder of the present disclosure may or may not contain other nutritional components and/or pharmacological components, as necessary, in addition to the Reikeijuu Kanto extract. . Such nutritional and pharmacological ingredients are not particularly limited as long as they are pharmaceutically acceptable, but include, for example, antacids, stomachic agents, digestive agents, intestinal regulation agents, antispasmodics, mucosal repair agents, anti-inflammatory agents, and astringents. agents, antiemetics, antitussives, expectorants, anti-inflammatory enzymes, sedative-hypnotics, antihistamines, caffeine, cardiotonic diuretics, antibacterial agents, vasoconstrictors, vasodilators, local anesthetics, herbal extracts (Reikeijukanto) (other than extracts), vitamins, menthol, etc. These nutritional components and/or pharmacological components may be used alone or in combination of two or more. Further, the content of these components is appropriately set depending on the type of components used, the formulation form of the crowd-congestion disorder alleviating drug, and the like. Preferably, the crowd disorder improving agent of the present disclosure does not contain any nutritional components or pharmacological components in addition to the Reigui Gakuanto extract.

Formulation The form of the preparation of the crowd-congestion disorder improving drug of the present disclosure is not particularly limited as long as it can be administered orally, but examples include powders, fine granules, granules (including dry syrup), tablets, and pills. , solid preparations such as capsules (soft capsules, hard capsules); semi-solid preparations such as jellies; and liquid preparations such as solutions, suspensions, and syrups. Among these formulations, solid formulations are preferred from the viewpoints of stability of the ingredients contained, portability, and the like.

In order to prepare the crowd-congestion disorder improving drug of the present disclosure into the above-mentioned formulation form, it is possible to prepare the drug in the pharmaceutical field by using the Reikeikyukanto extract and additives, bases, nutritional ingredients and/or pharmacological ingredients added as necessary. It may be formulated according to the usual formulation method employed in .

Uses The drug for improving crowd anxiety of the present disclosure is used for the purpose of improving crowd anxiety. Crowd disorder is a disorder induced by exposure to environments where people are crowded, such as in crowded vehicles (for example, crowded trains, crowded buses, etc.), downtown areas, event venues, etc.

Examples of crowd disorder include, for example, tension caused by other people approaching one's personal space, and in some cases even more others coming and going; many others coming into view, and in some cases even more others coming and going Disorders induced by stimuli specific to crowded environments, such as visual stimulation due to forced eye movement; sound and/or smell stimulation; and/or oxygen deficiency stimulation due to thinning of oxygen concentration, are listed. It will be done.

More specific examples of crowd discomfort include headache, dizziness, malaise, and/or fatigue.

Among these crowd disorders, from the viewpoint of further increasing the effect of improving crowd disorder, it is preferable to mention disorders brought about by stimuli specific to the environment inside a crowded car, and more preferably, disorders caused by stimuli specific to the environment inside a crowded car. headache, dizziness, malaise, and/or fatigue caused by stimulation of

There are no particular restrictions on the time periods during which you are exposed to crowd congestion, such as after 6:00 and before 12:00 (including the time when boarding a crowded train in the morning), after 12:00 and before 17:00, after 17:00 and before 8:00 p.m. Examples include before the passage of time (including the time when boarding a crowded train in the evening), after 20:00 and before 24:00, and preferably after 17:00 and before 20:00.

Dosage/Usage The crowding disorder improving drug of the present disclosure is used by oral administration. The dose of the crowd-congestion disorder improving drug of the present disclosure is appropriately set according to the age, sex, constitution, severity of symptoms, etc. of the subject to be administered. For example, 1 to 3 times a day in an amount of 0.3 to 2 g, preferably 0.6 to 1.5 g, in terms of dry extract final amount of Reikeikai Kanto extract per person per day; You can take it depending on how many times you are exposed to crowded environments. Further, for example, the dry extract powder amount of Reikeikai Kanto extract per person is about 0.1 to 1 g, preferably 0.2 to 0.75 g, and more preferably 0.3 to 1 g per person. The amount of 0.5g can be taken 1 to 3 times a day, preferably 2 times a day.

The timing of administration is not particularly limited, and may be taken before meals, after meals, or between meals. The medicine for improving crowd anxiety of the present disclosure has immediate effect, so it can be used as an as-needed medicine, for example, for the purpose of preventing crowd anxiety, within 6 hours, preferably within 5 hours of being exposed to a crowd environment. Preferably, it can be taken within 4 hours, more preferably within 3 hours.

EXAMPLES Hereinafter, the present invention will be specifically explained with reference to Examples, but the present invention is not limited to these Examples.

The raw materials for the production of Reikeikakuanto extract granules are used in the proportions of 6 parts by weight of Bukryō, 3 parts by weight of Soju, 4 parts by weight of cinnamon bark, and 2 parts by weight of licorice. The extract was extracted at about 100° C. for 1 hour, centrifuged to obtain an extract, concentrated under reduced pressure, and dried using a spray dryer to obtain a powdered Rei Guiju Ganto extract. The amount of the obtained Reikeijuu Kanto extract powder was 1.5 g per 15 g of the raw herbal medicine mixture. Note that drying with a spray dryer was performed by dropping the extract into an atomizer with a rotational speed of 10,000 rpm, and supplying hot air at 150°C. Furthermore, a granule preparation was prepared using the obtained Reikeijukanto extract powder. The daily dose of Reikeijuu Kanto extract powder was 0.75 g, and the dose of Rei Keijuu Kanto extract powder per dose was 0.325 g.

Experimental Example The subjects were eight men and women who complained of discomfort with crowds. These test subjects experienced complaints of headache, dizziness, fatigue, and/or fatigue (not including panic attacks) when boarding the crowded train.

Three hours before boarding a crowded train in the morning and a crowded train in the evening (we selected times when the level of congestion was the same for both) (before or between meals), we added 0.375 g of Ring Guijuu Sweet Tang Extract (dried). The patient took the granules at a dose equivalent to the extract equivalent amount.

Regarding the improvement effect of crowd-related disorder after one dose, we will examine the overall improvement effect of crowd-related disorder as well as the improvement of each complaint of crowd-related disorder (specifically, headache, malaise, fatigue, dizziness). Regarding the improvement effect, responses were received as ``I felt it'', ``I felt it somewhat'', ``I can't say either way'', ``I didn't feel it at all'', or ``I didn't feel it.'' Table 1 shows the ratio (%) of the number of people who responded for each evaluation. Table 1 also shows the ratio (%) of the total number of people who rated "I felt it" or "I felt it rather" as valid points.

As shown in Table 1, by taking Reikeikakuanto extract before boarding a train, various symptoms of crowd discomfort caused by riding on a crowded train are improved, and the overall improvement effect for crowd anxiety is high. Valid points were obtained. In particular, among the complaints, 100% of effective points were achieved for the overall improvement effect of crowd disorder, which is induced by riding on a crowded train in the evening, and an extremely high improvement effect was obtained.

Claims (4)

An anti-crowd medicine that contains Reikeijuu Kanto extract. 2. The crowd-related disorder improving drug according to claim 1, which is used to improve headache, dizziness, malaise, and/or fatigue induced in a crowded environment. The drug for improving crowd discomfort according to claim 1, which is used to improve discomfort induced by riding in a crowded vehicle. The crowd-related disorder improving drug according to claim 1, which is taken within 6 hours of being exposed to a crowded environment.