|
US6469158B1
(en)
|
1992-05-14 |
2002-10-22 |
Ribozyme Pharmaceuticals, Incorporated |
Synthesis, deprotection, analysis and purification of RNA and ribozymes
|
|
US5804683A
(en)
|
1992-05-14 |
1998-09-08 |
Ribozyme Pharmaceuticals, Inc. |
Deprotection of RNA with alkylamine
|
|
US5977343A
(en)
|
1992-05-14 |
1999-11-02 |
Ribozyme Pharmaceuticals, Inc. |
Synthesis, deprotection, analysis and purification of RNA and ribozymes
|
|
EP1253199A1
(en)
|
1993-09-02 |
2002-10-30 |
Ribozyme Pharmaceuticals, Inc. |
Abasic moieties containing enzymatic nucleic acids
|
|
US5889136A
(en)
|
1995-06-09 |
1999-03-30 |
The Regents Of The University Of Colorado |
Orthoester protecting groups in RNA synthesis
|
|
US5998203A
(en)
|
1996-04-16 |
1999-12-07 |
Ribozyme Pharmaceuticals, Inc. |
Enzymatic nucleic acids containing 5'-and/or 3'-cap structures
|
|
US6111086A
(en)
|
1998-02-27 |
2000-08-29 |
Scaringe; Stephen A. |
Orthoester protecting groups
|
|
KR20080023768A
(ko)
|
2000-03-30 |
2008-03-14 |
화이트헤드 인스티튜트 포 바이오메디칼 리서치 |
Ｒｎａ 간섭의 ｒｎａ 서열 특이적인 매개체
|
|
CN100523215C
(zh)
|
2000-12-01 |
2009-08-05 |
马普科技促进协会 |
介导rna干涉的小rna分子
|
|
US20050159378A1
(en)
|
2001-05-18 |
2005-07-21 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA)
|
|
WO2003040395A2
(en)
|
2001-11-07 |
2003-05-15 |
Applera Corporation |
Universal nucleotides for nucleic acid analysis
|
|
US20070265220A1
(en)
|
2004-03-15 |
2007-11-15 |
City Of Hope |
Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
|
|
WO2007030167A1
(en)
|
2005-09-02 |
2007-03-15 |
Nastech Pharmaceutical Company Inc. |
Modification of double-stranded ribonucleic acid molecules
|
|
WO2010033225A2
(en)
|
2008-09-22 |
2010-03-25 |
Dicerna Pharmaceuticals, Inc. |
Compositions and methods for the specific inhibition of gene expression by dsrna possessing modifications
|
|
KR20110110776A
(ko)
|
2008-12-18 |
2011-10-07 |
다이서나 파마수이티컬, 인크. |
유전자 발현의 특이적 억제를 위한 연장된 다이서 기질 제제 및 방법
|
|
WO2010093788A2
(en)
|
2009-02-11 |
2010-08-19 |
Dicerna Pharmaceuticals, Inc. |
Multiplex dicer substrate rna interference molecules having joining sequences
|
|
US8927513B2
(en)
|
2009-07-07 |
2015-01-06 |
Alnylam Pharmaceuticals, Inc. |
5′ phosphate mimics
|
|
US9725479B2
(en)
|
2010-04-22 |
2017-08-08 |
Ionis Pharmaceuticals, Inc. |
5′-end derivatives
|
|
KR102104401B1
(ko)
|
2011-03-29 |
2020-04-27 |
알닐람 파마슈티칼스 인코포레이티드 |
Tmprss6 유전자의 발현을 억제하기 위한 조성물 및 방법
|
|
AU2012328680A1
(en)
|
2011-10-25 |
2014-05-01 |
Ionis Pharmaceuticals, Inc. |
Antisense modulation of GCCR expression
|
|
EP2776564B1
(en)
|
2011-11-07 |
2019-10-02 |
Ionis Pharmaceuticals, Inc. |
Modulation of tmprss6 expression
|
|
AU2014268529C1
(en)
*
|
2013-05-22 |
2020-10-01 |
Alnylam Pharmaceuticals, Inc. |
TMPRSS6 iRNA compositions and methods of use thereof
|
|
EP3134732A2
(en)
*
|
2014-04-24 |
2017-03-01 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for detecting anti-drug antibodies
|
|
WO2016085852A1
(en)
|
2014-11-24 |
2016-06-02 |
Alnylam Pharmaceuticals, Inc. |
Tmprss6 irna compositions and methods of use thereof
|
|
EP3865576A1
(en)
|
2014-12-15 |
2021-08-18 |
Dicerna Pharmaceuticals, Inc. |
Ligand-modified double-stranded nucleic acids
|
|
CN107429250B
(zh)
|
2015-04-03 |
2022-03-01 |
Ionis制药公司 |
用于调节tmprss6表达的化合物和方法
|
|
WO2018045317A1
(en)
|
2016-09-02 |
2018-03-08 |
Dicerna Pharmaceuticals, Inc. |
4'-phosphate analogs and oligonucleotides comprising the same
|
|
EP4219714A3
(en)
|
2017-04-05 |
2023-08-30 |
Silence Therapeutics GmbH |
Rna interference mediated inhibition of tmprss6
|
|
US10675295B2
(en)
*
|
2017-06-29 |
2020-06-09 |
Dicerna Pharmaceuticals, Inc. |
Compositions and methods for inhibiting HMGB1 expression
|
|
EP3598995A1
(en)
|
2018-07-26 |
2020-01-29 |
Silence Therapeutics GmbH |
Products and compositions
|
|
IL284327B2
(en)
*
|
2018-12-28 |
2024-11-01 |
Dicerna Pharmaceuticals Inc |
Compositions and methods for inhibiting hmgb1 expression
|
|
TW202221120A
(zh)
*
|
2020-08-04 |
2022-06-01 |
美商黛瑟納製藥公司 |
用於治療代謝症候群之組成物及方法
|
|
IL307721A
(en)
|
2021-04-20 |
2023-12-01 |
Astrazeneca Ireland Ltd |
Compounds and methods for inhibiting expression of component 3
|
|
CA3216106A1
(en)
|
2021-04-26 |
2022-11-03 |
Alnylam Pharmaceuticals, Inc. |
Transmembrane protease, serine 6 (tmprss6) irna compositions and methods of use thereof
|
|
TWI868755B
(zh)
|
2022-06-24 |
2025-01-01 |
丹麥商諾佛 儂迪克股份有限公司 |
抑制跨膜絲胺酸蛋白酶６（ｔｍｐｒｓｓ６）表現的組成物及方法
|