JP2023553935A5 - - Google Patents
Info
- Publication number
- JP2023553935A5 JP2023553935A5 JP2023535332A JP2023535332A JP2023553935A5 JP 2023553935 A5 JP2023553935 A5 JP 2023553935A5 JP 2023535332 A JP2023535332 A JP 2023535332A JP 2023535332 A JP2023535332 A JP 2023535332A JP 2023553935 A5 JP2023553935 A5 JP 2023553935A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- mrna
- amino acid
- polypeptide
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063124060P | 2020-12-11 | 2020-12-11 | |
| US63/124,060 | 2020-12-11 | ||
| US202063130104P | 2020-12-23 | 2020-12-23 | |
| US63/130,104 | 2020-12-23 | ||
| US202163165636P | 2021-03-24 | 2021-03-24 | |
| US63/165,636 | 2021-03-24 | ||
| US202163275424P | 2021-11-03 | 2021-11-03 | |
| US63/275,424 | 2021-11-03 | ||
| PCT/US2021/062922 WO2022125968A1 (en) | 2020-12-11 | 2021-12-10 | Polynucleotides, compositions, and methods for genome editing involving deamination |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023553935A JP2023553935A (ja) | 2023-12-26 |
| JP2023553935A5 true JP2023553935A5 (https=) | 2025-09-04 |
Family
ID=80118959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023535332A Pending JP2023553935A (ja) | 2020-12-11 | 2021-12-10 | 脱アミノ化を伴うゲノム編集のためのポリヌクレオチド、組成物、及び方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20240002820A1 (https=) |
| EP (1) | EP4259792A1 (https=) |
| JP (1) | JP2023553935A (https=) |
| KR (1) | KR20230129996A (https=) |
| AU (1) | AU2021394998A1 (https=) |
| CA (1) | CA3205000A1 (https=) |
| CL (1) | CL2023001684A1 (https=) |
| CO (1) | CO2023009114A2 (https=) |
| CR (1) | CR20230305A (https=) |
| IL (1) | IL303506A (https=) |
| MX (1) | MX2023006876A (https=) |
| TW (1) | TW202237845A (https=) |
| WO (1) | WO2022125968A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022246266A1 (en) * | 2021-05-21 | 2022-11-24 | Beam Therapeutics Inc. | Base editing of transthyretin gene |
| WO2022261292A1 (en) * | 2021-06-10 | 2022-12-15 | Intellia Therapeutics, Inc. | Modified guide rnas comprising an internal linker for gene editing |
| IL312507A (en) * | 2021-11-03 | 2024-07-01 | Intellia Therapeutics Inc | Modified guide rnas for gene editing |
| CA3237303A1 (en) * | 2021-11-03 | 2023-05-11 | Intellia Therapeutics, Inc. | Polynucleotides, compositions, and methods for genome editing |
| WO2024006955A1 (en) | 2022-06-29 | 2024-01-04 | Intellia Therapeutics, Inc. | Engineered t cells |
| EP4638783A2 (en) | 2022-12-22 | 2025-10-29 | Intellia Therapeutics, Inc. | Methods for analyzing nucleic acid cargos of lipid nucleic acid assemblies |
| WO2024227082A1 (en) * | 2023-04-26 | 2024-10-31 | Vijay Sankaran | Base-editing perturbation screens and uses thereof |
| WO2025038637A1 (en) | 2023-08-14 | 2025-02-20 | Intellia Therapeutics, Inc. | Compositions and methods for genetically modifying transforming growth factor beta receptor type 2 (tgfβr2) |
| WO2025038642A1 (en) | 2023-08-14 | 2025-02-20 | Intellia Therapeutics, Inc. | Compositions and methods for genetically modifying cd70 |
| WO2025081064A2 (en) * | 2023-10-11 | 2025-04-17 | Illumina, Inc. | Thermophilic deaminase and methods for identifying modified cytosine |
| WO2025078604A1 (en) * | 2023-10-13 | 2025-04-17 | Smartcella Solutions Ab | Methods and compositions for delivery of unmodified mrna constructs using mesenchymal stem cells |
| WO2025128871A2 (en) | 2023-12-13 | 2025-06-19 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
| WO2025137439A2 (en) | 2023-12-20 | 2025-06-26 | Intellia Therapeutics, Inc. | Engineered t cells |
| WO2025255308A1 (en) | 2024-06-07 | 2025-12-11 | Intellia Therapeutics, Inc. | Cd8 co-receptor chimeric polypeptides in tcr cell therapy |
| WO2026006390A2 (en) * | 2024-06-26 | 2026-01-02 | Intellia Therapeutics, Inc. | Modified guide rnas for genome editing |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5585481A (en) | 1987-09-21 | 1996-12-17 | Gen-Probe Incorporated | Linking reagents for nucleotide probes |
| US5378825A (en) | 1990-07-27 | 1995-01-03 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs |
| JP3131222B2 (ja) | 1991-12-24 | 2001-01-31 | アイシス・ファーマシューティカルス・インコーポレーテッド | ギャップを有する２′修飾オリゴヌクレオチド |
| JPH10500310A (ja) | 1994-05-19 | 1998-01-13 | ダコ アクティーゼルスカブ | 淋菌及びトラコーマ クラミジアの検出のためのｐｎａ プローブ |
| WO2001075436A1 (en) | 2000-04-03 | 2001-10-11 | Board Of Trustees Of The Leland Stanford Junior University | A method for protein structure alignment |
| US20060051405A1 (en) | 2004-07-19 | 2006-03-09 | Protiva Biotherapeutics, Inc. | Compositions for the delivery of therapeutic agents and uses thereof |
| US7774185B2 (en) | 2004-09-14 | 2010-08-10 | International Business Machines Corporation | Protein structure alignment using cellular automata |
| US20140310830A1 (en) | 2012-12-12 | 2014-10-16 | Feng Zhang | CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes |
| CN107879960B (zh) | 2013-03-08 | 2021-06-22 | 诺华股份有限公司 | 用于传递活性成分的脂质和脂质组合物 |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| EP3083556B1 (en) | 2013-12-19 | 2019-12-25 | Novartis AG | Lipids and lipid compositions for the delivery of active agents |
| CN106794141B (zh) | 2014-07-16 | 2021-05-28 | 诺华股份有限公司 | 将核酸包封在脂质纳米粒主体中的方法 |
| KR20230156800A (ko) | 2015-03-03 | 2023-11-14 | 더 제너럴 하스피탈 코포레이션 | 변경된 PAM 특이성을 갖는 조작된 CRISPR-Cas9 뉴클레아제 |
| CN120842296A (zh) | 2015-09-21 | 2025-10-28 | 垂林克生物技术有限公司 | 用于合成5’-加帽rna的组合物和方法 |
| LT3436077T (lt) | 2016-03-30 | 2025-06-25 | Intellia Therapeutics, Inc. | Lipidų nanodalelių vaisto formos, skirtos crispr/cas komponentams |
| KR20180134412A (ko) | 2016-04-22 | 2018-12-18 | 인텔리아 테라퓨틱스, 인크. | 전사 인자 4에서 트라이뉴클레오타이드 반복부와 연관된 질환의 치료를 위한 조성물 및 방법 |
| SG10202106058WA (en) | 2016-12-08 | 2021-07-29 | Intellia Therapeutics Inc | Modified guide rnas |
| TWI851534B (zh) | 2016-12-22 | 2024-08-11 | 美商英特利亞醫療公司 | 用於治療α-１抗胰蛋白酶缺乏症之組合物及方法 |
| WO2019041296A1 (zh) * | 2017-09-01 | 2019-03-07 | 上海科技大学 | 一种碱基编辑系统及方法 |
| US20230140670A1 (en) | 2017-09-29 | 2023-05-04 | Intellia Therapeutics, Inc. | Formulations |
| EP3688161A1 (en) | 2017-09-29 | 2020-08-05 | Intellia Therapeutics, Inc. | Compositions and methods for ttr gene editing and treating attr amyloidosis |
| AU2019282824C1 (en) | 2018-06-08 | 2026-04-23 | Intellia Therapeutics, Inc. | Modified guide RNAS for gene editing |
| MX2021001070A (es) | 2018-07-31 | 2021-05-27 | Intellia Therapeutics Inc | Composiciones y métodos para editar el gen hidroxiácido oxidasa 1 (hao1) para tratar la hiperoxaluria primaria tipo 1 (ph1). |
| AU2019326408A1 (en) * | 2018-08-23 | 2021-03-11 | Sangamo Therapeutics, Inc. | Engineered target specific base editors |
| US20220009878A1 (en) | 2018-10-02 | 2022-01-13 | Intellia Therapeutics, Inc. | Ionizable amine lipids |
| IL282267B2 (en) | 2018-10-15 | 2026-03-01 | Univ Massachusetts | Programmed DNA editing by chimeric deaminase-nme2cas9 proteins |
| BR112021010853A2 (pt) | 2018-12-05 | 2021-08-31 | Intellia Therapeutics, Inc. | Lipídios de amina modificados |
| EP3911735A4 (en) * | 2019-01-16 | 2023-07-12 | Beam Therapeutics, Inc. | MODIFIED IMMUNE CELLS WITH INCREASED ANTINEOPLASTIC ACTIVITY AND RESISTANCE TO IMMUNOSUPPRESSION |
| AU2020248337A1 (en) * | 2019-03-28 | 2021-11-04 | Intellia Therapeutics, Inc. | Compositions and methods for ttr gene editing and treating ATTR amyloidosis comprising a corticosteroid or use thereof |
| CN114127044A (zh) | 2019-04-25 | 2022-03-01 | 英特利亚治疗股份有限公司 | 可电离的胺类脂质和脂质纳米颗粒 |
-
2021
- 2021-12-10 IL IL303506A patent/IL303506A/en unknown
- 2021-12-10 CA CA3205000A patent/CA3205000A1/en active Pending
- 2021-12-10 KR KR1020237022781A patent/KR20230129996A/ko active Pending
- 2021-12-10 AU AU2021394998A patent/AU2021394998A1/en active Pending
- 2021-12-10 WO PCT/US2021/062922 patent/WO2022125968A1/en not_active Ceased
- 2021-12-10 CR CR20230305A patent/CR20230305A/es unknown
- 2021-12-10 MX MX2023006876A patent/MX2023006876A/es unknown
- 2021-12-10 TW TW110146322A patent/TW202237845A/zh unknown
- 2021-12-10 EP EP21852000.5A patent/EP4259792A1/en active Pending
- 2021-12-10 JP JP2023535332A patent/JP2023553935A/ja active Pending
-
2023
- 2023-06-09 CL CL2023001684A patent/CL2023001684A1/es unknown
- 2023-06-09 US US18/332,335 patent/US20240002820A1/en active Pending
- 2023-07-07 CO CONC2023/0009114A patent/CO2023009114A2/es unknown
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