JP2023551535A - Ｔ細胞がんを治療するための方法および材料 - Google Patents

Ｔ細胞がんを治療するための方法および材料 Download PDF

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JP2023551535A
JP2023551535A JP2023533230A JP2023533230A JP2023551535A JP 2023551535 A JP2023551535 A JP 2023551535A JP 2023533230 A JP2023533230 A JP 2023533230A JP 2023533230 A JP2023533230 A JP 2023533230A JP 2023551535 A JP2023551535 A JP 2023551535A
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polypeptide
seq
amino acid
cells
cell
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JP2023551535A5 (enExample
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サラ ディナポリ
ジャクリン ダグラス
エミリー ハン－チュン シュエ
マイケル エス． フアン
ケネス ダブリュ． キンズラー
マキシミリアン コニグ
ブライアン ジェイ． モグ
ニコラス パパドポウロス
アンドリュー エム． パードール
スマン ポール
アレクサンダー エイチ． パールマン
バート フォーゲルシュタイン
シビン チョウ
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ザ・ジョンズ・ホプキンス・ユニバーシティー
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2023533230A 2020-12-01 2021-12-01 Ｔ細胞がんを治療するための方法および材料 Pending JP2023551535A (ja)

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US202063119753P 2020-12-01 2020-12-01
US63/119,753 2020-12-01
PCT/US2021/061453 WO2022119955A1 (en) 2020-12-01 2021-12-01 Methods and materials for treating t cell cancers

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JP2023551535A true JP2023551535A (ja) 2023-12-08
JP2023551535A5 JP2023551535A5 (enExample) 2024-11-29

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US (1) US20240002541A1 (enExample)
EP (1) EP4255482A1 (enExample)
JP (1) JP2023551535A (enExample)
CN (1) CN116867519A (enExample)
AU (1) AU2021392655A1 (enExample)
CA (1) CA3203773A1 (enExample)
WO (1) WO2022119955A1 (enExample)

Families Citing this family (5)

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Publication number Priority date Publication date Assignee Title
CN120076829A (zh) 2022-10-18 2025-05-30 明治制果药业株式会社 T细胞肿瘤的治疗剂
US20260193361A1 (en) * 2022-11-11 2026-07-09 Pasithea Therapeutics Corp. Anti-alpha5 integrin antibodies and uses thereof
IL326971A (en) * 2023-09-05 2026-05-01 Michele Pitaro Single-chain variable fragment and molecules derived therefrom that bind the trvb5-1 fragment of the β chain of the human T-cell receptor
WO2025247325A1 (en) * 2024-05-30 2025-12-04 Hanx Biopharmaceuticals, (Wuhan) Ltd. Antibody-drug conjugates targeting trbv12 and uses thereof
WO2026011103A1 (en) * 2024-07-03 2026-01-08 Yale University Tcr-vβeta specific therapeutic molecules and uses thereof

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09509307A (ja) * 1993-12-08 1997-09-22 ティー セル サイエンスィズ インコーポレイテッド ヒト化抗体及びそれらの使用
JP2005000169A (ja) * 1991-06-14 2005-01-06 Genentech Inc 免疫グロブリン変異体
JP2005514371A (ja) * 2001-11-28 2005-05-19 ノバルティス アクチエンゲゼルシャフト 抗ｔ細胞免疫毒素融合タンパク質およびその治療的使用
JP2018517712A (ja) * 2015-06-01 2018-07-05 メディジーン イミュノテラピーズ ゲーエムベーハー Ｔ細胞受容体特異的抗体
WO2020010250A2 (en) * 2018-07-03 2020-01-09 Elstar Therapeutics, Inc. Anti-tcr antibody molecules and uses thereof
WO2020091635A2 (ru) * 2018-12-25 2020-05-07 Закрытое Акционерное Общество "Биокад" Гуманизированные антитела против участка бета цепи 9-го семейства trbv9 ткр человека, и способы их применения
JP2020520920A (ja) * 2017-05-16 2020-07-16 ザ・ジョンズ・ホプキンス・ユニバーシティ Ｍａｎａボディおよび使用方法
WO2020172598A1 (en) * 2019-02-21 2020-08-27 Elstar Therapeutics, Inc. Multifunctional molecules that bind to t cells and uses thereof to treat autoimmune disorders
WO2020172596A1 (en) * 2019-02-21 2020-08-27 Elstar Therapeutics, Inc. Anti-tcr antibody molecules and thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3192810A1 (en) * 2016-01-14 2017-07-19 Deutsches Krebsforschungszentrum Psma binding antibody and uses thereof

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005000169A (ja) * 1991-06-14 2005-01-06 Genentech Inc 免疫グロブリン変異体
JPH09509307A (ja) * 1993-12-08 1997-09-22 ティー セル サイエンスィズ インコーポレイテッド ヒト化抗体及びそれらの使用
JP2005514371A (ja) * 2001-11-28 2005-05-19 ノバルティス アクチエンゲゼルシャフト 抗ｔ細胞免疫毒素融合タンパク質およびその治療的使用
JP2018517712A (ja) * 2015-06-01 2018-07-05 メディジーン イミュノテラピーズ ゲーエムベーハー Ｔ細胞受容体特異的抗体
JP2020520920A (ja) * 2017-05-16 2020-07-16 ザ・ジョンズ・ホプキンス・ユニバーシティ Ｍａｎａボディおよび使用方法
WO2020010250A2 (en) * 2018-07-03 2020-01-09 Elstar Therapeutics, Inc. Anti-tcr antibody molecules and uses thereof
WO2020091635A2 (ru) * 2018-12-25 2020-05-07 Закрытое Акционерное Общество "Биокад" Гуманизированные антитела против участка бета цепи 9-го семейства trbv9 ткр человека, и способы их применения
WO2020172598A1 (en) * 2019-02-21 2020-08-27 Elstar Therapeutics, Inc. Multifunctional molecules that bind to t cells and uses thereof to treat autoimmune disorders
WO2020172596A1 (en) * 2019-02-21 2020-08-27 Elstar Therapeutics, Inc. Anti-tcr antibody molecules and thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LOUISE F. RISNES ET AL.: "Disease-driving CD4+ T cell clonotypes persist for decades in celiac disease", JOURNAL OF CLINICAL INVESTIGATION, vol. 128, no. 6, JPN6025044694, June 2018 (2018-06-01), pages 2642 - 2650, ISSN: 0005721306 *

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AU2021392655A1 (en) 2023-06-22
US20240002541A1 (en) 2024-01-04
CA3203773A1 (en) 2022-06-09
EP4255482A1 (en) 2023-10-11
AU2021392655A9 (en) 2024-05-02
WO2022119955A1 (en) 2022-06-09
CN116867519A (zh) 2023-10-10

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