JP2023551110A - Ｉｌ‐１７モジュレーターとしてのジシクロプロピルメチル誘導体 - Google Patents

Ｉｌ‐１７モジュレーターとしてのジシクロプロピルメチル誘導体 Download PDF

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Publication number
JP2023551110A
JP2023551110A JP2023527430A JP2023527430A JP2023551110A JP 2023551110 A JP2023551110 A JP 2023551110A JP 2023527430 A JP2023527430 A JP 2023527430A JP 2023527430 A JP2023527430 A JP 2023527430A JP 2023551110 A JP2023551110 A JP 2023551110A
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JP
Japan
Prior art keywords
formula
compound
alkyl
pharmaceutically acceptable
oxide
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2023527430A
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English (en)
Japanese (ja)
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JP2023551110A5 (enExample
Inventor
リチャード フロスト、ジェイムズ
ウィリアム ハスレット、グレゴリー
トーマス レウベルソン、ジェイムズ
Original Assignee
ユーシービー バイオファルマ エスアールエル
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Priority claimed from GBGB2017642.6A external-priority patent/GB202017642D0/en
Priority claimed from GBGB2108945.3A external-priority patent/GB202108945D0/en
Application filed by ユーシービー バイオファルマ エスアールエル filed Critical ユーシービー バイオファルマ エスアールエル
Publication of JP2023551110A publication Critical patent/JP2023551110A/ja
Publication of JP2023551110A5 publication Critical patent/JP2023551110A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2023527430A 2020-11-09 2021-11-01 Ｉｌ‐１７モジュレーターとしてのジシクロプロピルメチル誘導体 Pending JP2023551110A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB2017642.6A GB202017642D0 (en) 2020-11-09 2020-11-09 Therapeputic agents
GB2017642.6 2020-11-09
GB2108945.3 2021-06-22
GBGB2108945.3A GB202108945D0 (en) 2021-06-22 2021-06-22 Therapeutic agents
PCT/EP2021/080251 WO2022096412A1 (en) 2020-11-09 2021-11-01 Dicyclopropylmethyl derivatives as il-17 modulators

Publications (2)

Publication Number Publication Date
JP2023551110A true JP2023551110A (ja) 2023-12-07
JP2023551110A5 JP2023551110A5 (enExample) 2024-10-15

Family

ID=78536191

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023527430A Pending JP2023551110A (ja) 2020-11-09 2021-11-01 Ｉｌ‐１７モジュレーターとしてのジシクロプロピルメチル誘導体

Country Status (6)

Country Link
US (1) US20230399328A1 (enExample)
EP (1) EP4240742A1 (enExample)
JP (1) JP2023551110A (enExample)
CN (1) CN116406267A (enExample)
CA (1) CA3199816A1 (enExample)
WO (1) WO2022096412A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR126255A1 (es) 2021-07-01 2023-10-04 UCB Biopharma SRL Derivados de imidazotriazina como moduladores de il-17
WO2023025783A1 (en) 2021-08-23 2023-03-02 Leo Pharma A/S Small molecule modulators of il-17
WO2023111181A1 (en) 2021-12-16 2023-06-22 Leo Pharma A/S Small molecule modulators of il-17
WO2023166172A1 (en) 2022-03-04 2023-09-07 Leo Pharma A/S Small molecule modulators of il-17
GB202210731D0 (en) 2022-07-22 2022-09-07 UCB Biopharma SRL Therapeutic agents
TW202430165A (zh) 2022-12-02 2024-08-01 丹麥商理奧藥品公司 Il-17之小分子調節劑

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019138017A1 (en) * 2018-01-15 2019-07-18 Ucb Biopharma Sprl Fused imidazole derivatives as il-17 modulators
WO2020127685A1 (en) * 2018-12-19 2020-06-25 Leo Pharma A/S Amino-acid anilides as small molecule modulators of il-17

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2242504B1 (en) 2008-01-09 2021-07-14 The Schepens Eye Research Institute, Inc. Therapeutic compositions for treatment of ocular inflammatory disorders
EP2809660B1 (en) 2012-02-02 2016-01-20 Ensemble Therapeutics Corporation Macrocyclic compounds for modulating il-17
WO2014066726A2 (en) 2012-10-26 2014-05-01 Ensemble Therapeutics Corporation Compounds for modulating il-17
GB201709456D0 (en) 2017-06-14 2017-07-26 Ucb Biopharma Sprl Therapeutic agents
CN110511213B (zh) 2018-05-22 2021-10-19 成都先导药物开发股份有限公司 一种免疫调节剂
EP3820567A1 (en) 2018-07-12 2021-05-19 UCB Biopharma SRL Spirocyclic indane analogues as il-17 modulators
GB201820165D0 (en) 2018-12-11 2019-01-23 Ucb Biopharma Sprl Therapeutic agents
GB201820166D0 (en) 2018-12-11 2019-01-23 Ucb Biopharma Sprl Therapeutic agents
TWI752400B (zh) 2019-01-07 2022-01-11 美商美國禮來大藥廠 Il-17a抑制劑
US20220162191A1 (en) 2019-03-08 2022-05-26 Leo Pharma A/S Small molecule modulators of il-17
GB201909191D0 (en) 2019-06-26 2019-08-07 Ucb Biopharma Sprl Therapeutic agents
GB201909190D0 (en) 2019-06-26 2019-08-07 Ucb Biopharma Sprl Therapeutic agents
GB201909194D0 (en) 2019-06-26 2019-08-07 Ucb Biopharma Sprl Therapeutic agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019138017A1 (en) * 2018-01-15 2019-07-18 Ucb Biopharma Sprl Fused imidazole derivatives as il-17 modulators
WO2020127685A1 (en) * 2018-12-19 2020-06-25 Leo Pharma A/S Amino-acid anilides as small molecule modulators of il-17

Also Published As

Publication number Publication date
WO2022096412A1 (en) 2022-05-12
CN116406267A (zh) 2023-07-07
EP4240742A1 (en) 2023-09-13
CA3199816A1 (en) 2022-05-12
US20230399328A1 (en) 2023-12-14

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