JP2023540888A - 非天然の改変Fc受容体に特異的に結合する、ヒトIgGの非天然の改変Fc領域 - Google Patents

非天然の改変Fc受容体に特異的に結合する、ヒトIgGの非天然の改変Fc領域 Download PDF

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JP2023540888A
JP2023540888A JP2023512109A JP2023512109A JP2023540888A JP 2023540888 A JP2023540888 A JP 2023540888A JP 2023512109 A JP2023512109 A JP 2023512109A JP 2023512109 A JP2023512109 A JP 2023512109A JP 2023540888 A JP2023540888 A JP 2023540888A
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hla
cells
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隆一 守屋
宏樹 白井
真司 曽我
尚子 嶋田
デヴィッド ウィリアム ラッセル
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Astellas Pharma Inc
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JP2023512109A 2020-08-19 2021-08-18 非天然の改変Fc受容体に特異的に結合する、ヒトIgGの非天然の改変Fc領域 Pending JP2023540888A (ja)

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US202063067629P 2020-08-19 2020-08-19
US63/067,629 2020-08-19
PCT/IB2021/000556 WO2022038411A1 (en) 2020-08-19 2021-08-18 Human non-naturally occurring modified fc region of igg specifically binding to non-naturally occurring modified fc receptor

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JP2023540888A true JP2023540888A (ja) 2023-09-27
JP2023540888A5 JP2023540888A5 (https=) 2024-08-23

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US (1) US20230303658A1 (https=)
EP (1) EP4200325A1 (https=)
JP (1) JP2023540888A (https=)
KR (1) KR20230052279A (https=)
CN (1) CN116322749A (https=)
AU (1) AU2021328717A1 (https=)
BR (1) BR112023003036A2 (https=)
CA (1) CA3189553A1 (https=)
IL (1) IL300484A (https=)
MX (1) MX2023002013A (https=)
WO (1) WO2022038411A1 (https=)

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GB202204016D0 (en) * 2022-03-22 2022-05-04 Ucl Business Plc Affinity chromatography ligands for antibody glycovariant separation

Citations (1)

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Publication number Priority date Publication date Assignee Title
JP2003512019A (ja) * 1999-01-15 2003-04-02 ジェネンテック・インコーポレーテッド 変化したエフェクター機能を有するポリペプチド変異体

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US6737056B1 (en) * 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
CA2650730A1 (en) * 2006-04-27 2007-11-08 Pikamab, Inc. Methods and compositions for antibody therapy
JP2013528357A (ja) * 2010-03-29 2013-07-11 ザイムワークス,インコーポレイテッド 強化又は抑制されたエフェクター機能を有する抗体
US9233125B2 (en) 2010-12-14 2016-01-12 University Of Maryland, Baltimore Universal anti-tag chimeric antigen receptor-expressing T cells and methods of treating cancer
CA3205636A1 (en) 2011-04-20 2012-10-26 University Of Washington Through Its Center For Commercialization Beta-2 microglobulin-deficient cells
FI2838548T3 (fi) 2012-04-17 2023-10-02 Univ Washington Through Its Center For Commercialization HLA:n luokan II puutteelliset solut, HLA:n luokan II puutteelliset solut, jotka kykenevät ilmentämään HLA:n luokan II proteiineja, ja niiden käytöt
EP2990416B1 (en) 2014-08-29 2018-06-20 GEMoaB Monoclonals GmbH Universal chimeric antigen receptor expressing immune cells for targeting of diverse multiple antigens and method of manufacturing the same and use of the same for treatment of cancer, infections and autoimmune disorders
KR20180075689A (ko) 2015-11-23 2018-07-04 트르스티스 오브 보스톤 유니버시티 키메라 항원 수용체에 관한 방법 및 조성물
EP3430036A4 (en) 2016-03-18 2019-08-14 Unum Therapeutics MODIFIED CHIMERIC RECEPTORS AND USES IN IMMUNOTHERAPY

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003512019A (ja) * 1999-01-15 2003-04-02 ジェネンテック・インコーポレーテッド 変化したエフェクター機能を有するポリペプチド変異体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MIMOTO, F. ET AL., MOLECULAR IMMUNOLOGY, vol. 58, no. 1, JPN6025045433, 2014, pages 132 - 138, ISSN: 0005726646 *

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MX2023002013A (es) 2023-04-11
IL300484A (en) 2023-04-01
BR112023003036A2 (pt) 2023-04-25
WO2022038411A1 (en) 2022-02-24
CA3189553A1 (en) 2022-02-24
KR20230052279A (ko) 2023-04-19
AU2021328717A1 (en) 2023-04-13
US20230303658A1 (en) 2023-09-28
EP4200325A1 (en) 2023-06-28
CN116322749A (zh) 2023-06-23

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