JP2023540436A - Ｐｄ－ｌ１およびｔｇｆ－βを標的とする二機能性分子 - Google Patents

Ｐｄ－ｌ１およびｔｇｆ－βを標的とする二機能性分子 Download PDF

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JP2023540436A
JP2023540436A JP2023505901A JP2023505901A JP2023540436A JP 2023540436 A JP2023540436 A JP 2023540436A JP 2023505901 A JP2023505901 A JP 2023505901A JP 2023505901 A JP2023505901 A JP 2023505901A JP 2023540436 A JP2023540436 A JP 2023540436A
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seq
amino acid
antibody
acid sequence
fragment
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Japanese (ja)
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ウェンツ ゴン，
イーウェイ トウ，
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レプ バイオファーマ カンパニー リミテッド
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Publication of JP2023540436A publication Critical patent/JP2023540436A/ja
Priority to JP2024187749A priority Critical patent/JP7846734B2/ja
Priority to JP2025194419A priority patent/JP2026015500A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2023505901A 2020-07-28 2021-07-27 Ｐｄ－ｌ１およびｔｇｆ－βを標的とする二機能性分子 Withdrawn JP2023540436A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2024187749A JP7846734B2 (ja) 2020-07-28 2024-10-24 Ｐｄ－ｌ１およびｔｇｆ－βを標的とする二機能性分子
JP2025194419A JP2026015500A (ja) 2020-07-28 2025-11-13 Ｐｄ－ｌ１およびｔｇｆ－βを標的とする二機能性分子

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CNPCT/CN2020/105286 2020-07-28
CN2020105286 2020-07-28
CN2021098476 2021-06-04
CNPCT/CN2021/098476 2021-06-04
PCT/CN2021/108643 WO2022022503A1 (en) 2020-07-28 2021-07-27 Bifunctional molecules targeting pd-l1 and tgf-beta

Related Child Applications (1)

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JP2024187749A Division JP7846734B2 (ja) 2020-07-28 2024-10-24 Ｐｄ－ｌ１およびｔｇｆ－βを標的とする二機能性分子

Publications (1)

Publication Number Publication Date
JP2023540436A true JP2023540436A (ja) 2023-09-25

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Family Applications (3)

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JP2023505901A Withdrawn JP2023540436A (ja) 2020-07-28 2021-07-27 Ｐｄ－ｌ１およびｔｇｆ－βを標的とする二機能性分子
JP2024187749A Active JP7846734B2 (ja) 2020-07-28 2024-10-24 Ｐｄ－ｌ１およびｔｇｆ－βを標的とする二機能性分子
JP2025194419A Pending JP2026015500A (ja) 2020-07-28 2025-11-13 Ｐｄ－ｌ１およびｔｇｆ－βを標的とする二機能性分子

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JP2024187749A Active JP7846734B2 (ja) 2020-07-28 2024-10-24 Ｐｄ－ｌ１およびｔｇｆ－βを標的とする二機能性分子
JP2025194419A Pending JP2026015500A (ja) 2020-07-28 2025-11-13 Ｐｄ－ｌ１およびｔｇｆ－βを標的とする二機能性分子

Country Status (9)

Country Link
US (1) US20230287125A1 (cg-RX-API-DMAC10.html)
EP (1) EP4188950A4 (cg-RX-API-DMAC10.html)
JP (3) JP2023540436A (cg-RX-API-DMAC10.html)
KR (1) KR20230050356A (cg-RX-API-DMAC10.html)
CN (4) CN121319180A (cg-RX-API-DMAC10.html)
AU (1) AU2021317376A1 (cg-RX-API-DMAC10.html)
IL (1) IL299966A (cg-RX-API-DMAC10.html)
PH (1) PH12023550193A1 (cg-RX-API-DMAC10.html)
WO (1) WO2022022503A1 (cg-RX-API-DMAC10.html)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL322840A (en) * 2023-02-20 2025-10-01 Akeso Biopharma Co Ltd Fusion protein comprising a TGF-βRII extracellular region fragment, its pharmaceutical composition and use

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018527949A (ja) * 2015-08-06 2018-09-27 ウーシー バイオロジクス（シャンハイ）カンパニー リミテッド 新規抗ｐｄ−ｌ１抗体
WO2018205985A1 (zh) * 2017-05-12 2018-11-15 江苏恒瑞医药股份有限公司 含有TGF-β受体的融合蛋白及其医药用途
WO2019113464A1 (en) * 2017-12-08 2019-06-13 Elstar Therapeutics, Inc. Multispecific molecules and uses thereof
JP2019516394A (ja) * 2016-03-23 2019-06-20 マブスペース バイオサイエンシズ （スーチョウ） カンパニー，リミテッド 新規抗ｐｄ−ｌ１抗体
JP2020504095A (ja) * 2016-12-08 2020-02-06 イーライ リリー アンド カンパニー 抗ＰＤ−Ｌ１抗体との組み合わせのための抗Ｔｉｍ−３抗体

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
HRP20210977T1 (hr) * 2014-02-10 2021-09-17 Merck Patent Gmbh Ciljano inhibiranje tgf beta
CN107686520B (zh) * 2016-08-04 2023-01-03 信达生物制药(苏州)有限公司 抗pd-l1纳米抗体及其应用
CN109575140B (zh) * 2017-09-29 2021-02-23 北京比洋生物技术有限公司 靶向pd-1或pd-l1且靶向vegf家族的双靶向融合蛋白及其用途
EP3470429A1 (en) * 2017-10-10 2019-04-17 Numab Innovation AG Antibodies targeting pdl1 and methods of use thereof
CN109721657B (zh) * 2017-10-27 2021-11-02 北京比洋生物技术有限公司 阻断pd-1/pd-l1信号传导途径且活化t细胞的融合蛋白及其用途
BR112020019827A2 (pt) * 2018-03-29 2021-01-05 I-Mab Biopharma Us Limited Anticorpo ou fragmento do mesmo, anticorpo biespecífico, composição, polinucleotídeo nucleotídeo, célula isolada, e, métodos para tratar câncer ou infecção e detectar a expressão de pd-l1 em uma amostra
CN113271962A (zh) * 2018-08-22 2021-08-17 默克专利有限公司 利用靶向TGF-β抑制的三阴性乳腺癌的治疗
CA3118415A1 (en) * 2018-11-09 2020-05-14 Jiangsu Hengrui Medicine Co., Ltd. Tgf-.beta. receptor fusion protein pharmaceutical composition and use thereof
EP3990116A1 (en) * 2019-06-28 2022-05-04 Gensun Biopharma Inc. ANTITUMOR ANTAGONIST CONSISTING OF A MUTATED TGFß1 - RII EXTRACELLULAR DOMAIN AND AN IMMUNOGLOBULIN SCAFFOLD
US11028174B1 (en) * 2020-07-28 2021-06-08 Lepu Biopharma Co., Ltd. Bifunctional molecules targeting PD-L1 and TGF-β
CN112940134B (zh) * 2021-05-11 2021-09-03 正大天晴药业集团南京顺欣制药有限公司 针对PD-1和TGF-β的双功能蛋白

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018527949A (ja) * 2015-08-06 2018-09-27 ウーシー バイオロジクス（シャンハイ）カンパニー リミテッド 新規抗ｐｄ−ｌ１抗体
JP2019516394A (ja) * 2016-03-23 2019-06-20 マブスペース バイオサイエンシズ （スーチョウ） カンパニー，リミテッド 新規抗ｐｄ−ｌ１抗体
JP2020504095A (ja) * 2016-12-08 2020-02-06 イーライ リリー アンド カンパニー 抗ＰＤ−Ｌ１抗体との組み合わせのための抗Ｔｉｍ−３抗体
WO2018205985A1 (zh) * 2017-05-12 2018-11-15 江苏恒瑞医药股份有限公司 含有TGF-β受体的融合蛋白及其医药用途
WO2019113464A1 (en) * 2017-12-08 2019-06-13 Elstar Therapeutics, Inc. Multispecific molecules and uses thereof

Also Published As

Publication number Publication date
CN119462927B (zh) 2025-07-29
JP2025010203A (ja) 2025-01-20
CN121319180A (zh) 2026-01-13
IL299966A (en) 2023-03-01
CN119409832A (zh) 2025-02-11
WO2022022503A1 (en) 2022-02-03
EP4188950A1 (en) 2023-06-07
EP4188950A4 (en) 2025-01-22
CN119462927A (zh) 2025-02-18
CN116348493B (zh) 2025-10-17
AU2021317376A1 (en) 2023-02-23
CN116348493A (zh) 2023-06-27
CN119409832B (zh) 2025-08-01
JP2026015500A (ja) 2026-01-29
US20230287125A1 (en) 2023-09-14
JP7846734B2 (ja) 2026-04-15
PH12023550193A1 (en) 2024-06-24
KR20230050356A (ko) 2023-04-14

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