JP2023537632A - 疼痛の処置のためのＮａＶ１．７の非水和ケトン阻害剤 - Google Patents

疼痛の処置のためのＮａＶ１．７の非水和ケトン阻害剤 Download PDF

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JP2023537632A
JP2023537632A JP2023511616A JP2023511616A JP2023537632A JP 2023537632 A JP2023537632 A JP 2023537632A JP 2023511616 A JP2023511616 A JP 2023511616A JP 2023511616 A JP2023511616 A JP 2023511616A JP 2023537632 A JP2023537632 A JP 2023537632A
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alkyl
halo
groups
optionally substituted
compound
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JP2023537632A5 (enExample
Inventor
パジョウヘシュ，ハッサン
ムルカイ，ジョン
モンテレオーネ，デニス
チョウ，シャン
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サイトワン セラピューティクス インコーポレイテッド
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Publication of JP2023537632A publication Critical patent/JP2023537632A/ja
Publication of JP2023537632A5 publication Critical patent/JP2023537632A5/ja
Priority to JP2026036645A priority Critical patent/JP2026116909A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2023511616A 2020-08-14 2021-08-14 疼痛の処置のためのＮａＶ１．７の非水和ケトン阻害剤 Pending JP2023537632A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2026036645A JP2026116909A (ja) 2020-08-14 2026-03-06 疼痛の処置のためのＮａＶ１．７の非水和ケトン阻害剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063066012P 2020-08-14 2020-08-14
US63/066,012 2020-08-14
PCT/US2021/046054 WO2022036297A1 (en) 2020-08-14 2021-08-14 Non-hydrated ketone inhibitors of nav1.7 for the treatment of pain

Related Child Applications (1)

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JP2026036645A Division JP2026116909A (ja) 2020-08-14 2026-03-06 疼痛の処置のためのＮａＶ１．７の非水和ケトン阻害剤

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JP2023537632A true JP2023537632A (ja) 2023-09-04
JP2023537632A5 JP2023537632A5 (enExample) 2024-09-02

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JP2023511616A Pending JP2023537632A (ja) 2020-08-14 2021-08-14 疼痛の処置のためのＮａＶ１．７の非水和ケトン阻害剤
JP2026036645A Pending JP2026116909A (ja) 2020-08-14 2026-03-06 疼痛の処置のためのＮａＶ１．７の非水和ケトン阻害剤

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JP2026036645A Pending JP2026116909A (ja) 2020-08-14 2026-03-06 疼痛の処置のためのＮａＶ１．７の非水和ケトン阻害剤

Country Status (12)

Country Link
US (1) US20230339958A1 (enExample)
EP (2) EP4196482B1 (enExample)
JP (2) JP2023537632A (enExample)
KR (1) KR20230051252A (enExample)
CN (1) CN116368139A (enExample)
AU (1) AU2021326546A1 (enExample)
BR (1) BR112023002659A2 (enExample)
CA (1) CA3188924A1 (enExample)
ES (1) ES3061196T3 (enExample)
IL (1) IL300626A (enExample)
MX (1) MX2023001741A (enExample)
WO (1) WO2022036297A1 (enExample)

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CA3058214A1 (en) 2017-03-29 2018-10-04 The Board Of Trustees Of The Leland Stanford Junior University 11,13-modified saxitoxins for the treatment of pain
EP3860714B1 (en) 2018-10-03 2023-09-06 Siteone Therapeutics, Inc. 11,13-modified saxitoxins for the treatment of pain
CA3221939A1 (en) 2021-06-04 2022-12-08 Vertex Pharmaceuticals Incorporated N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamide analogs as modulators of sodium channels
CN117794918A (zh) 2021-06-04 2024-03-29 沃泰克斯药物股份有限公司 经取代的四氢呋喃类似物作为钠通道调节剂
WO2022256842A1 (en) 2021-06-04 2022-12-08 Vertex Pharmaceuticals Incorporated Hydroxy and (halo)alkoxy substituted tetrahydrofurans as modulators of sodium channels
US20240368135A1 (en) 2021-06-04 2024-11-07 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofuran-2-carboxamides as modulators of sodium channels
SMT202600064T1 (it) 2021-06-04 2026-03-09 Vertex Pharma Forme farmaceutiche solide e regimi di dosaggio comprendenti (2r,3s,4s,5r)-4-[[3-(3,4-difluoro-2-metossi-fenil)-4,5-dimetil-5-(trifluorometil) tetraidrofuran-2-carbonil]ammino]piridin-2-carbossammide
SI4347031T1 (sl) 2021-06-04 2026-01-30 Vertex Pharmaceuticals Incorporated N-(hidroksialkil (hetero)aril) tetrahidrofuran karboksamidi kot modulatorji natrijevih kanalčkov
AU2023255558A1 (en) 2022-04-22 2024-10-31 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
AU2023257313A1 (en) 2022-04-22 2024-10-31 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
JP2025513455A (ja) 2022-04-22 2025-04-24 バーテックス ファーマシューティカルズ インコーポレイテッド 疼痛の治療のためのヘテロアリール化合物
IL316422A (en) 2022-04-22 2024-12-01 Vertex Pharma Heteroaryl compounds for pain treatment
KR20250120351A (ko) 2022-12-06 2025-08-08 버텍스 파마슈티칼스 인코포레이티드 나트륨 채널의 치환된 테트라하이드로푸란 조절제의 합성을 위한 방법
KR20260116140A (ko) 2023-10-23 2026-07-28 버텍스 파마슈티칼스 인코포레이티드 통증 치료를 위한 헤테로아릴 화합물
TW202535867A (zh) 2023-10-23 2025-09-16 美商維泰克斯製藥公司 用於治療疼痛之鈉通道調節劑及其固體形式的製備方法
KR20260116141A (ko) 2023-10-23 2026-07-28 버텍스 파마슈티칼스 인코포레이티드 통증 치료용 화합물 및 이의 고체 형태의 제조방법
KR20260118418A (ko) 2023-10-23 2026-07-30 버텍스 파마슈티칼스 인코포레이티드 통증 치료를 위한 헤테로아릴 화합물
AU2024393245A1 (en) 2023-12-07 2026-06-18 Vertex Pharmaceuticals Incorporated Dosing regimens and formulations of suzetrigine for use in the treatment of acute and chronic pain
TW202606663A (zh) 2024-06-28 2026-02-16 美商維泰克斯製藥公司 用於治療疼痛之雜芳基化合物
LU605402B1 (en) 2024-07-11 2026-07-14 Sea4Us Biotecnologia E Recursos Marinhos Sa Oxazolidone-derived compounds and their use in the treatment of chronic and acute pain
WO2026030525A1 (en) 2024-07-31 2026-02-05 Vertex Pharmaceuticals Incorporated Zilvetrigine dosage forms and dosing regimens for treating pain

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JP2013519653A (ja) * 2010-02-10 2013-05-30 ファイトトックス リミテッド サキシトキシン誘導体での触覚の喪失の処置
WO2018183782A1 (en) * 2017-03-29 2018-10-04 Siteone Therapeutics, Inc. 11,13-modified saxitoxins for the treatment of pain
JP2018534270A (ja) * 2015-09-30 2018-11-22 サイトワン セラピューティクス， インコーポレイテッド 疼痛の治療のための１１，１３−修飾サキシトキシン
WO2020072835A1 (en) * 2018-10-03 2020-04-09 Siteone Therapeutics, Inc. 11,13-modified saxitoxins for the treatment of pain

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Also Published As

Publication number Publication date
EP4647075A3 (en) 2026-01-14
EP4647075A2 (en) 2025-11-12
WO2022036297A1 (en) 2022-02-17
ES3061196T3 (en) 2026-03-31
EP4196482B1 (en) 2025-10-01
CN116368139A (zh) 2023-06-30
MX2023001741A (es) 2023-04-25
BR112023002659A2 (pt) 2023-05-02
AU2021326546A1 (en) 2023-04-13
CA3188924A1 (en) 2022-02-17
US20230339958A1 (en) 2023-10-26
IL300626A (en) 2023-04-01
KR20230051252A (ko) 2023-04-17
EP4196482A1 (en) 2023-06-21
JP2026116909A (ja) 2026-07-14

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