JP2023534951A5 - - Google Patents
Info
- Publication number
- JP2023534951A5 JP2023534951A5 JP2023502828A JP2023502828A JP2023534951A5 JP 2023534951 A5 JP2023534951 A5 JP 2023534951A5 JP 2023502828 A JP2023502828 A JP 2023502828A JP 2023502828 A JP2023502828 A JP 2023502828A JP 2023534951 A5 JP2023534951 A5 JP 2023534951A5
- Authority
- JP
- Japan
- Prior art keywords
- dsrna
- nucleotide
- nucleotides
- group
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063052811P | 2020-07-16 | 2020-07-16 | |
| US63/052,811 | 2020-07-16 | ||
| PCT/US2021/041946 WO2022016043A1 (en) | 2020-07-16 | 2021-07-16 | Conjugated oligonucleotides for tissue specific delivery |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023534951A JP2023534951A (ja) | 2023-08-15 |
| JP2023534951A5 true JP2023534951A5 (enExample) | 2024-07-25 |
Family
ID=79554340
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023502828A Pending JP2023534951A (ja) | 2020-07-16 | 2021-07-16 | 組織特異的送達のためのコンジュゲートされたオリゴヌクレオチド |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20220042015A1 (enExample) |
| EP (1) | EP4181932A4 (enExample) |
| JP (1) | JP2023534951A (enExample) |
| CN (1) | CN116600817A (enExample) |
| AU (1) | AU2021308657A1 (enExample) |
| CA (1) | CA3174068A1 (enExample) |
| WO (1) | WO2022016043A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018031933A2 (en) * | 2016-08-12 | 2018-02-15 | University Of Massachusetts | Conjugated oligonucleotides |
| BR112021002440A2 (pt) | 2018-08-10 | 2021-05-04 | University Of Massachusetts | oligonucleotídeos modificados visando snps |
| WO2020041769A1 (en) | 2018-08-23 | 2020-02-27 | University Of Massachusetts | O-methyl rich fully stabilized oligonucleotides |
| US12365894B2 (en) | 2019-09-16 | 2025-07-22 | University Of Massachusetts | Branched lipid conjugates of siRNA for specific tissue delivery |
| CA3174079A1 (en) | 2020-05-26 | 2021-12-02 | Anastasia Khvorova | Synthetic oligonucleotides having regions of block and cluster modifications |
| US12366070B2 (en) | 2021-04-23 | 2025-07-22 | Stephen Cochran | Cover for circular-profile downspouts having protection from animal/insect intrusion and damage/debris accumulation |
| CA3262515A1 (en) | 2022-07-25 | 2024-02-01 | Amgen Inc. | ARNI CONSTRUCTIONS AND METHODS FOR INHIBITING FAM13A EXPRESSION |
| US20260049309A1 (en) * | 2022-08-15 | 2026-02-19 | Novo Nordisk A/S | Regulation of activity of rnai molecules |
| EP4594520A2 (en) | 2022-09-30 | 2025-08-06 | Sixfold Bioscience Ltd. | Compositions containing oligonucleotides with theranostic applications |
| CN120112649A (zh) * | 2022-09-30 | 2025-06-06 | 马萨诸塞大学 | 靶向s6k1的寡核苷酸 |
| WO2025217569A1 (en) * | 2024-04-11 | 2025-10-16 | University Of Massachusetts | Conjugated chemically-modified dsrna during ex vivo perfusion of organs |
| TW202615058A (zh) * | 2024-06-12 | 2026-04-16 | 美商艾拉倫製藥股份有限公司 | 失養強直性肌肉蛋白質激酶（ｄｍｐｋ）ｉｒｎａ組成物及其使用方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010090762A1 (en) * | 2009-02-04 | 2010-08-12 | Rxi Pharmaceuticals Corporation | Rna duplexes with single stranded phosphorothioate nucleotide regions for additional functionality |
| WO2018031933A2 (en) * | 2016-08-12 | 2018-02-15 | University Of Massachusetts | Conjugated oligonucleotides |
| US11433089B2 (en) * | 2016-09-23 | 2022-09-06 | National University Corporation Tokyo Medical And Dental University | Blood-brain barrier permeable heteroduplex nucleic acid |
| CA3098623A1 (en) * | 2018-05-07 | 2019-11-14 | Alnylam Pharmaceuticals, Inc. | Extrahepatic delivery |
| WO2022109398A1 (en) * | 2020-11-23 | 2022-05-27 | University Of Massachusetts | Oligonucleotides for dgat2 modulation |
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2021
- 2021-07-16 EP EP21843183.1A patent/EP4181932A4/en active Pending
- 2021-07-16 AU AU2021308657A patent/AU2021308657A1/en active Pending
- 2021-07-16 WO PCT/US2021/041946 patent/WO2022016043A1/en not_active Ceased
- 2021-07-16 US US17/377,632 patent/US20220042015A1/en active Pending
- 2021-07-16 CN CN202180061336.7A patent/CN116600817A/zh active Pending
- 2021-07-16 JP JP2023502828A patent/JP2023534951A/ja active Pending
- 2021-07-16 CA CA3174068A patent/CA3174068A1/en active Pending