JP2023522701A5 - - Google Patents
Info
- Publication number
- JP2023522701A5 JP2023522701A5 JP2022563451A JP2022563451A JP2023522701A5 JP 2023522701 A5 JP2023522701 A5 JP 2023522701A5 JP 2022563451 A JP2022563451 A JP 2022563451A JP 2022563451 A JP2022563451 A JP 2022563451A JP 2023522701 A5 JP2023522701 A5 JP 2023522701A5
- Authority
- JP
- Japan
- Prior art keywords
- dsrna
- nucleotides
- antisense strand
- nucleotide
- chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063012603P | 2020-04-20 | 2020-04-20 | |
| US63/012,603 | 2020-04-20 | ||
| PCT/US2021/028166 WO2021216556A2 (en) | 2020-04-20 | 2021-04-20 | Oligonucleotides for msh3 modulation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2026063763A Division JP2026129735A (ja) | 2020-04-20 | 2026-04-08 | Ｍｓｈ３調節のためのオリゴヌクレオチド |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023522701A JP2023522701A (ja) | 2023-05-31 |
| JP2023522701A5 true JP2023522701A5 (enExample) | 2024-05-02 |
Family
ID=78270051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022563451A Pending JP2023522701A (ja) | 2020-04-20 | 2021-04-20 | Ｍｓｈ３調節のためのオリゴヌクレオチド |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20210355491A1 (enExample) |
| EP (1) | EP4138860A4 (enExample) |
| JP (1) | JP2023522701A (enExample) |
| AU (1) | AU2021260581A1 (enExample) |
| CA (1) | CA3176204A1 (enExample) |
| WO (1) | WO2021216556A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3929293A3 (en) | 2015-04-03 | 2022-03-16 | University Of Massachusetts | Fully stabilized asymmetric sirna |
| WO2017030973A1 (en) | 2015-08-14 | 2017-02-23 | University Of Massachusetts | Bioactive conjugates for oligonucleotide delivery |
| WO2018237245A1 (en) | 2017-06-23 | 2018-12-27 | University Of Massachusetts | TWO TAIL SELF-ADMINISTRATION SIRNA AND ASSOCIATED METHODS |
| BR112021002440A2 (pt) | 2018-08-10 | 2021-05-04 | University Of Massachusetts | oligonucleotídeos modificados visando snps |
| WO2020041769A1 (en) | 2018-08-23 | 2020-02-27 | University Of Massachusetts | O-methyl rich fully stabilized oligonucleotides |
| CN113614232A (zh) | 2019-01-18 | 2021-11-05 | 马萨诸塞大学 | 动态药代动力学修饰锚 |
| KR20220047989A (ko) | 2019-08-09 | 2022-04-19 | 유니버시티 오브 매사추세츠 | Snp를 표적화하는 화학적으로 변형된 올리고뉴클레오타이드 |
| US12365894B2 (en) | 2019-09-16 | 2025-07-22 | University Of Massachusetts | Branched lipid conjugates of siRNA for specific tissue delivery |
| EP4146807A4 (en) * | 2020-05-08 | 2024-09-04 | Takeda Pharmaceuticals U.S.A., Inc. | METHODS OF TREATING NUCLEOTIDE AMPLIFICATION DISEASES ASSOCIATED WITH MSH3 ACTIVITY |
| CA3174079A1 (en) | 2020-05-26 | 2021-12-02 | Anastasia Khvorova | Synthetic oligonucleotides having regions of block and cluster modifications |
| US11408000B2 (en) | 2020-06-03 | 2022-08-09 | Triplet Therapeutics, Inc. | Oligonucleotides for the treatment of nucleotide repeat expansion disorders associated with MSH3 activity |
| EP4164656A4 (en) * | 2020-06-11 | 2025-10-22 | Ionis Pharmaceuticals Inc | COMPOUNDS AND METHODS FOR REDUCING MSH3 EXPRESSION |
| BR112023019981A2 (pt) | 2021-03-29 | 2023-12-12 | Alnylam Pharmaceuticals Inc | Composições do agente irna de huntingtina (htt) e métodos de uso das mesmas |
| EP4423272A2 (en) * | 2021-10-29 | 2024-09-04 | Alnylam Pharmaceuticals, Inc. | Huntingtin (htt) irna agent compositions and methods of use thereof |
| WO2023114989A2 (en) * | 2021-12-17 | 2023-06-22 | University Of Massachusetts | Oligonucleotides for mlh3 modulation |
| US20240035027A1 (en) * | 2022-05-04 | 2024-02-01 | University Of Massachusetts | Oligonucleotides for pms2 modulation |
| WO2023225495A2 (en) * | 2022-05-16 | 2023-11-23 | Atalanta Therapeutics, Inc. | Compositions and methods for treatment of microsatellite dna expansion disorders |
| WO2024064954A2 (en) * | 2022-09-23 | 2024-03-28 | The Children's Hospital Of Philadelphia | Compositions and methods for treating huntington's disease and related disorders |
| CN122341734A (zh) * | 2023-10-11 | 2026-07-03 | 优尼科生物制药有限公司 | 重复扩增障碍中msh3的核酸调节 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPO974597A0 (en) * | 1997-10-10 | 1997-11-06 | Rhone-Poulenc Agro | Methods for obtaining plant varieties |
| US7361468B2 (en) * | 2004-07-02 | 2008-04-22 | Affymetrix, Inc. | Methods for genotyping polymorphisms in humans |
| US20150307876A1 (en) * | 2012-02-10 | 2015-10-29 | Regents Of The University Of Minnesota | Dna assimilation |
| WO2015171918A2 (en) * | 2014-05-07 | 2015-11-12 | Louisiana State University And Agricultural And Mechanical College | Compositions and uses for treatment thereof |
| CA3255657A1 (en) * | 2015-02-10 | 2025-12-01 | Genzyme Corporation | VARIANT RNAi |
| RS60762B1 (sr) * | 2015-04-03 | 2020-10-30 | Univ Massachusetts | Oligonukleotidna jedinjenja za ciljane irnk hantingtina |
| US20170009304A1 (en) * | 2015-07-07 | 2017-01-12 | Splicingcodes.Com | Method and kit for detecting fusion transcripts |
| WO2017132669A1 (en) * | 2016-01-31 | 2017-08-03 | University Of Massachusetts | Branched oligonucleotides |
| WO2020117702A1 (en) * | 2018-12-03 | 2020-06-11 | Triplet Therapeutics, Inc. | Methods for the treatment of trinucleotide repeat expansion disorders associated with msh3 activity |
-
2021
- 2021-04-20 WO PCT/US2021/028166 patent/WO2021216556A2/en not_active Ceased
- 2021-04-20 EP EP21792058.6A patent/EP4138860A4/en active Pending
- 2021-04-20 AU AU2021260581A patent/AU2021260581A1/en active Pending
- 2021-04-20 JP JP2022563451A patent/JP2023522701A/ja active Pending
- 2021-04-20 CA CA3176204A patent/CA3176204A1/en active Pending
- 2021-04-20 US US17/235,153 patent/US20210355491A1/en active Pending
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