JP2023534460A - コンジュゲーション部位を有するｔ細胞調節性ポリペプチド及びその使用方法 - Google Patents

コンジュゲーション部位を有するｔ細胞調節性ポリペプチド及びその使用方法 Download PDF

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JP2023534460A
JP2023534460A JP2023502701A JP2023502701A JP2023534460A JP 2023534460 A JP2023534460 A JP 2023534460A JP 2023502701 A JP2023502701 A JP 2023502701A JP 2023502701 A JP2023502701 A JP 2023502701A JP 2023534460 A JP2023534460 A JP 2023534460A
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cell
polypeptide
sequence
mod
sequences
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JP2023534460A5 (cg-RX-API-DMAC10.html
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ディー． セイデル ザ サード ロナルド
ジェイ． チャパルロ ロドルフォ
エフ． ロス ジョン
メング ロー チー
スリ アニッシュ
ジェイ． モニズ レイモンド
サグ ガーパンナ
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キュー バイオファーマ，インコーポレーテッド
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Publication of JP2023534460A5 publication Critical patent/JP2023534460A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2023502701A 2020-07-14 2021-07-14 コンジュゲーション部位を有するｔ細胞調節性ポリペプチド及びその使用方法 Pending JP2023534460A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202063051472P 2020-07-14 2020-07-14
US63/051,472 2020-07-14
US202063110929P 2020-11-06 2020-11-06
US63/110,929 2020-11-06
US202063120677P 2020-12-02 2020-12-02
US63/120,677 2020-12-02
PCT/US2021/041675 WO2022015880A2 (en) 2020-07-14 2021-07-14 T-cell modulatory polypeptides with conjugation sites and methods of use thereof

Publications (2)

Publication Number Publication Date
JP2023534460A true JP2023534460A (ja) 2023-08-09
JP2023534460A5 JP2023534460A5 (cg-RX-API-DMAC10.html) 2024-07-26

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JP2023502701A Pending JP2023534460A (ja) 2020-07-14 2021-07-14 コンジュゲーション部位を有するｔ細胞調節性ポリペプチド及びその使用方法

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US (1) US20230279076A1 (cg-RX-API-DMAC10.html)
EP (1) EP4182465A4 (cg-RX-API-DMAC10.html)
JP (1) JP2023534460A (cg-RX-API-DMAC10.html)
KR (1) KR20230052881A (cg-RX-API-DMAC10.html)
CN (1) CN116437952A (cg-RX-API-DMAC10.html)
AU (1) AU2021309842A1 (cg-RX-API-DMAC10.html)
CA (1) CA3174097A1 (cg-RX-API-DMAC10.html)
IL (1) IL299834A (cg-RX-API-DMAC10.html)
TW (1) TW202216750A (cg-RX-API-DMAC10.html)
WO (1) WO2022015880A2 (cg-RX-API-DMAC10.html)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201808552XA (en) * 2016-05-18 2018-10-30 Cue Biopharma Inc T-cell modulatory multimeric polypeptides and methods of use thereof
CN110325205B (zh) 2016-12-22 2023-08-15 库尔生物制药有限公司 T细胞调节性多聚体多肽及其使用方法
US11851471B2 (en) 2017-01-09 2023-12-26 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
KR20240005989A (ko) 2017-03-15 2024-01-12 큐 바이오파마, 인크. 면역 반응을 조절하는 방법
WO2019051127A1 (en) 2017-09-07 2019-03-14 Cue Biopharma, Inc. MULTIMER MODULATOR POLYPEPTIDE OF LYMPHOCYTE T HAVING CONJUGATION SITES AND METHODS OF USE THEREOF
IL296209A (en) 2020-05-12 2022-11-01 Cue Biopharma Inc Multimeric t-cell modulatory polypeptides and methods of using them
JP2023541366A (ja) 2020-09-09 2023-10-02 キュー バイオファーマ， インコーポレイテッド １型真性糖尿病（ｔ１ｄ）を治療するためのｍｈｃクラスｉｉ ｔ細胞調節多量体ポリペプチド及びその使用方法
CA3248038A1 (en) * 2022-04-12 2023-10-19 Minerva Biotechnologies Corporation ANTI-MUC1* VARIABLE ANTIBODIES AND RELATED USES
JP2025515575A (ja) * 2022-04-14 2025-05-20 キュー バイオファーマ， インコーポレイテッド Ｔ細胞エンゲージングポリペプチドおよびその使用方法
WO2024206207A1 (en) * 2023-03-24 2024-10-03 Neximmune, Inc. Injectable artificial antigen presenting cells for immune therapy
EP4484441A1 (en) * 2023-06-26 2025-01-01 Eberhard-Karls-Universität Tübingen Mhc-class i derived polypeptide
WO2025207816A1 (en) * 2024-03-27 2025-10-02 Cue Biopharma, Inc. Treatment of b-cell mediated immune disorders by t-cell mediated depletion of b cells, plasmablasts and plasma cells
CN118027176B (zh) * 2024-03-27 2024-12-24 郑春杨 人β2-微球蛋白突变体
WO2026125765A1 (en) 2024-12-13 2026-06-18 Immunoscape Pte. Ltd. Combination therapy

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016501900A (ja) * 2012-12-21 2016-01-21 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ジスルフィド結合した多価ｍｈｃクラスｉを含む多機能タンパク質
WO2019126818A1 (en) * 2017-12-23 2019-06-27 Rubius Therapeutics, Inc. Artificial antigen presenting cells and methods of use
WO2020132297A1 (en) * 2018-12-19 2020-06-25 Cue Biopharma, Inc. Multimeric t-cell modulatory polypeptides and methods of use thereof
WO2020132366A2 (en) * 2018-12-19 2020-06-25 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides with conjugation sites and methods of use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3014458A1 (en) * 2016-03-02 2017-09-08 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
KR20240005989A (ko) * 2017-03-15 2024-01-12 큐 바이오파마, 인크. 면역 반응을 조절하는 방법
MX2020002596A (es) * 2017-09-07 2020-07-20 Cue Biopharma Inc Polipeptidos moduladores de linfocitos t multimericos y metodos de uso de estos.
IL293978A (en) * 2019-12-20 2022-08-01 Regeneron Pharma New il2 agonists and methods of using them

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016501900A (ja) * 2012-12-21 2016-01-21 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ジスルフィド結合した多価ｍｈｃクラスｉを含む多機能タンパク質
WO2019126818A1 (en) * 2017-12-23 2019-06-27 Rubius Therapeutics, Inc. Artificial antigen presenting cells and methods of use
WO2020132297A1 (en) * 2018-12-19 2020-06-25 Cue Biopharma, Inc. Multimeric t-cell modulatory polypeptides and methods of use thereof
WO2020132366A2 (en) * 2018-12-19 2020-06-25 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides with conjugation sites and methods of use thereof

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Publication number Publication date
EP4182465A2 (en) 2023-05-24
WO2022015880A3 (en) 2022-03-03
TW202216750A (zh) 2022-05-01
IL299834A (en) 2023-03-01
US20230279076A1 (en) 2023-09-07
WO2022015880A2 (en) 2022-01-20
CN116437952A (zh) 2023-07-14
AU2021309842A1 (en) 2023-02-16
CA3174097A1 (en) 2022-01-20
KR20230052881A (ko) 2023-04-20
EP4182465A4 (en) 2024-08-07

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