TW202216750A - 具有結合位點之ｔ細胞調節多肽及其使用方法 - Google Patents
具有結合位點之ｔ細胞調節多肽及其使用方法 Download PDFInfo
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
Landscapes
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- Peptides Or Proteins (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| US202063110929P | 2020-11-06 | 2020-11-06 | |
| US63/110,929 | 2020-11-06 | ||
| US202063120677P | 2020-12-02 | 2020-12-02 | |
| US63/120,677 | 2020-12-02 |
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| SG11201808552XA (en) * | 2016-05-18 | 2018-10-30 | Cue Biopharma Inc | T-cell modulatory multimeric polypeptides and methods of use thereof |
| CN110325205B (zh) | 2016-12-22 | 2023-08-15 | 库尔生物制药有限公司 | T细胞调节性多聚体多肽及其使用方法 |
| US11851471B2 (en) | 2017-01-09 | 2023-12-26 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| KR20240005989A (ko) | 2017-03-15 | 2024-01-12 | 큐 바이오파마, 인크. | 면역 반응을 조절하는 방법 |
| WO2019051127A1 (en) | 2017-09-07 | 2019-03-14 | Cue Biopharma, Inc. | MULTIMER MODULATOR POLYPEPTIDE OF LYMPHOCYTE T HAVING CONJUGATION SITES AND METHODS OF USE THEREOF |
| IL296209A (en) | 2020-05-12 | 2022-11-01 | Cue Biopharma Inc | Multimeric t-cell modulatory polypeptides and methods of using them |
| JP2023541366A (ja) | 2020-09-09 | 2023-10-02 | キュー バイオファーマ， インコーポレイテッド | １型真性糖尿病（ｔ１ｄ）を治療するためのｍｈｃクラスｉｉ ｔ細胞調節多量体ポリペプチド及びその使用方法 |
| CA3248038A1 (en) * | 2022-04-12 | 2023-10-19 | Minerva Biotechnologies Corporation | ANTI-MUC1* VARIABLE ANTIBODIES AND RELATED USES |
| JP2025515575A (ja) * | 2022-04-14 | 2025-05-20 | キュー バイオファーマ， インコーポレイテッド | Ｔ細胞エンゲージングポリペプチドおよびその使用方法 |
| WO2024206207A1 (en) * | 2023-03-24 | 2024-10-03 | Neximmune, Inc. | Injectable artificial antigen presenting cells for immune therapy |
| EP4484441A1 (en) * | 2023-06-26 | 2025-01-01 | Eberhard-Karls-Universität Tübingen | Mhc-class i derived polypeptide |
| WO2025207816A1 (en) * | 2024-03-27 | 2025-10-02 | Cue Biopharma, Inc. | Treatment of b-cell mediated immune disorders by t-cell mediated depletion of b cells, plasmablasts and plasma cells |
| CN118027176B (zh) * | 2024-03-27 | 2024-12-24 | 郑春杨 | 人β2-微球蛋白突变体 |
| WO2026125765A1 (en) | 2024-12-13 | 2026-06-18 | Immunoscape Pte. Ltd. | Combination therapy |
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| CA3014458A1 (en) * | 2016-03-02 | 2017-09-08 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| KR20240005989A (ko) * | 2017-03-15 | 2024-01-12 | 큐 바이오파마, 인크. | 면역 반응을 조절하는 방법 |
| MX2020002596A (es) * | 2017-09-07 | 2020-07-20 | Cue Biopharma Inc | Polipeptidos moduladores de linfocitos t multimericos y metodos de uso de estos. |
| CA3084674A1 (en) * | 2017-12-23 | 2019-06-27 | Rubius Therapeutics, Inc. | Artificial antigen presenting cells and methods of use |
| TWI856047B (zh) * | 2018-12-19 | 2024-09-21 | 美商信號生物製藥公司 | 多聚體ｔ細胞調節多肽及其使用方法 |
| WO2020132366A2 (en) * | 2018-12-19 | 2020-06-25 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides with conjugation sites and methods of use thereof |
| IL293978A (en) * | 2019-12-20 | 2022-08-01 | Regeneron Pharma | New il2 agonists and methods of using them |
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| EP4182465A2 (en) | 2023-05-24 |
| JP2023534460A (ja) | 2023-08-09 |
| WO2022015880A3 (en) | 2022-03-03 |
| IL299834A (en) | 2023-03-01 |
| US20230279076A1 (en) | 2023-09-07 |
| WO2022015880A2 (en) | 2022-01-20 |
| CN116437952A (zh) | 2023-07-14 |
| AU2021309842A1 (en) | 2023-02-16 |
| CA3174097A1 (en) | 2022-01-20 |
| KR20230052881A (ko) | 2023-04-20 |
| EP4182465A4 (en) | 2024-08-07 |
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