JP2023532904A - 修飾ｉｌ－２ポリペプチドを含むポリペプチド及びその使用 - Google Patents

修飾ｉｌ－２ポリペプチドを含むポリペプチド及びその使用 Download PDF

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Publication number
JP2023532904A
JP2023532904A JP2022580769A JP2022580769A JP2023532904A JP 2023532904 A JP2023532904 A JP 2023532904A JP 2022580769 A JP2022580769 A JP 2022580769A JP 2022580769 A JP2022580769 A JP 2022580769A JP 2023532904 A JP2023532904 A JP 2023532904A
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Japan
Prior art keywords
polypeptide
binding domain
antigen binding
modified
substitution
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JP2022580769A
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English (en)
Japanese (ja)
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JP2023532904A5 (https=
Inventor
ジョン シー． ティマー
フロリアン スルツマイアー
ケイトリン エム． ウィリス
ブライアン ベックランド
ブレンダン ピー． エッケルマン
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Sanofi Aatd Inc
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Inhibrx Inc
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Application filed by Inhibrx Inc filed Critical Inhibrx Inc
Publication of JP2023532904A publication Critical patent/JP2023532904A/ja
Publication of JP2023532904A5 publication Critical patent/JP2023532904A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
JP2022580769A 2020-07-02 2021-07-01 修飾ｉｌ－２ポリペプチドを含むポリペプチド及びその使用 Pending JP2023532904A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063047681P 2020-07-02 2020-07-02
US63/047,681 2020-07-02
PCT/US2021/040061 WO2022006380A2 (en) 2020-07-02 2021-07-01 Polypeptides comprising modified il-2 polypeptides and uses thereof

Publications (2)

Publication Number Publication Date
JP2023532904A true JP2023532904A (ja) 2023-08-01
JP2023532904A5 JP2023532904A5 (https=) 2024-07-03

Family

ID=77127075

Family Applications (1)

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JP2022580769A Pending JP2023532904A (ja) 2020-07-02 2021-07-01 修飾ｉｌ－２ポリペプチドを含むポリペプチド及びその使用

Country Status (12)

Country Link
US (1) US20230235005A1 (https=)
EP (1) EP4175979A2 (https=)
JP (1) JP2023532904A (https=)
KR (1) KR20230035076A (https=)
CN (1) CN116615440A (https=)
AR (1) AR122863A1 (https=)
AU (1) AU2021299552A1 (https=)
CA (1) CA3184618A1 (https=)
IL (1) IL299542A (https=)
MX (1) MX2022016532A (https=)
TW (1) TW202216745A (https=)
WO (1) WO2022006380A2 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230112632A (ko) 2020-10-23 2023-07-27 애셔 바이오테라퓨틱스, 인크. 면역 세포 기능을 조절하기 위한 cd8 항원 결합 분자와의 융합
IL308609A (en) 2021-05-19 2024-01-01 Asher Biotherapeutics Inc IL-21 polypeptides and target constructs
WO2023133393A1 (en) * 2022-01-05 2023-07-13 Inhibrx, Inc. Gamma delta t-cell-targeted modified il-2 polypeptides and uses thereof
WO2023151661A1 (zh) * 2022-02-11 2023-08-17 江苏恒瑞医药股份有限公司 免疫缀合物及其用途
CN119546343A (zh) * 2022-04-27 2025-02-28 亚设生物治疗公司 细胞因子融合蛋白与cd8抗原结合分子的组合
US20240076343A1 (en) 2022-06-16 2024-03-07 Cephalon Llc Anti-pd-1 antibody-attenuated il-2 immunoconjugates and uses thereof
WO2024008126A1 (en) * 2022-07-06 2024-01-11 Elpiscience (Suzhou) Biopharma, Ltd. Il2 muteins and uses thereof
CN116041539B (zh) * 2022-10-31 2023-07-21 山东博安生物技术股份有限公司 Il-2突变体免疫缀合物
KR20250143339A (ko) * 2023-02-06 2025-10-01 메르크 파텐트 게엠베하 VHH-기반 NKp46 결합제
AU2024330564A1 (en) 2023-08-30 2026-04-02 Xilio Development, Inc. Vhh masked cytokines and methods of use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007528728A (ja) * 2004-03-05 2007-10-18 カイロン コーポレーション 改善されたインターロイキン−２ムテイン
JP2018512151A (ja) * 2016-05-04 2018-05-17 アムジエン・インコーポレーテツド 制御性ｔ細胞の増殖のためのインターロイキン−２変異タンパク質
WO2020060122A1 (ko) * 2018-09-17 2020-03-26 (주)지아이이노베이션 Il-2 단백질 및 cd80 단백질을 포함하는 융합단백질 및 이의 용도
WO2020247843A2 (en) * 2019-06-05 2020-12-10 Asher Biotherapeutics, Inc. Fusions of mutant interleukin-2 polypeptides with antigen binding molecules for modulating immune cell function

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US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
EP1400536A1 (en) 1991-06-14 2004-03-24 Genentech Inc. Method for making humanized antibodies
DK1034298T3 (da) 1997-12-05 2012-01-30 Scripps Research Inst Humanisering af murint antistof
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
CA2541651C (en) 2003-10-22 2011-05-24 Keck Graduate Institute Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy
EP1740615B1 (en) 2004-03-31 2014-11-05 Genentech, Inc. Humanized anti-tgf-beta antibodies
WO2015164815A1 (en) * 2014-04-24 2015-10-29 The Board Of Trustees Of The Leland Stanford Junior University Superagonists, partial agonists and antagonists of interleukin-2
ES2973548T3 (es) * 2016-12-22 2024-06-20 Cue Biopharma Inc Polipéptidos multiméricos moduladores de linfocitos T y métodos para su uso
KR20250156190A (ko) * 2018-06-22 2025-10-31 큐진 인크. 인터루킨-2 변이체 및 이의 사용 방법
SG11202106700WA (en) * 2019-01-07 2021-07-29 Inhibrx Inc Polypeptides comprising modified il-2 polypeptides and uses thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007528728A (ja) * 2004-03-05 2007-10-18 カイロン コーポレーション 改善されたインターロイキン−２ムテイン
JP2018512151A (ja) * 2016-05-04 2018-05-17 アムジエン・インコーポレーテツド 制御性ｔ細胞の増殖のためのインターロイキン−２変異タンパク質
WO2020060122A1 (ko) * 2018-09-17 2020-03-26 (주)지아이이노베이션 Il-2 단백질 및 cd80 단백질을 포함하는 융합단백질 및 이의 용도
WO2020247843A2 (en) * 2019-06-05 2020-12-10 Asher Biotherapeutics, Inc. Fusions of mutant interleukin-2 polypeptides with antigen binding molecules for modulating immune cell function

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
STAUBER DJ. ET AL.: "Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor", PROC NATL ACAD SCI USA, vol. 103, JPN6025044641, 2006, pages 2788 - 2793, ISSN: 0005722700 *
TAKEYOSHI M. ET AL.: "Cloning and sequence of guinea pig interleukin 2 (IL-2)", ARCH TOXICOL, vol. 72, JPN6025023818, 1998, pages 676 - 678, ISSN: 0005722699 *
ZURAWSKI SM. ET AL.: "Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeri", EMBO J., vol. 12, no. 13, JPN6025023819, 1993, pages 5113 - 5119, ISSN: 0005722698 *

Also Published As

Publication number Publication date
WO2022006380A2 (en) 2022-01-06
EP4175979A2 (en) 2023-05-10
TW202216745A (zh) 2022-05-01
WO2022006380A3 (en) 2022-02-24
KR20230035076A (ko) 2023-03-10
CN116615440A (zh) 2023-08-18
MX2022016532A (es) 2023-04-12
CA3184618A1 (en) 2022-01-06
AU2021299552A1 (en) 2023-02-02
AR122863A1 (es) 2022-10-12
US20230235005A1 (en) 2023-07-27
IL299542A (en) 2023-02-01

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