JPWO2022006380A5 - - Google Patents
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- JPWO2022006380A5 JPWO2022006380A5 JP2022580769A JP2022580769A JPWO2022006380A5 JP WO2022006380 A5 JPWO2022006380 A5 JP WO2022006380A5 JP 2022580769 A JP2022580769 A JP 2022580769A JP 2022580769 A JP2022580769 A JP 2022580769A JP WO2022006380 A5 JPWO2022006380 A5 JP WO2022006380A5
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- Prior art keywords
- antigen
- binding domain
- polypeptide
- substitution
- domain binds
- Prior art date
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- 239000000427 antigen Substances 0.000 claims 105
- 102000036639 antigens Human genes 0.000 claims 105
- 108091007433 antigens Proteins 0.000 claims 105
- 238000006467 substitution reaction Methods 0.000 claims 75
- 229920001184 polypeptide Polymers 0.000 claims 73
- 102000004196 processed proteins & peptides Human genes 0.000 claims 73
- 108090000765 processed proteins & peptides Proteins 0.000 claims 73
- 150000001413 amino acids Chemical group 0.000 claims 44
- 108010002350 Interleukin-2 Proteins 0.000 claims 36
- 102200027864 rs62514902 Human genes 0.000 claims 21
- 102220096696 rs62625272 Human genes 0.000 claims 20
- 102220497892 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11_H16A_mutation Human genes 0.000 claims 19
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 19
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 19
- 102220097722 rs876660020 Human genes 0.000 claims 17
- 210000001744 T-lymphocyte Anatomy 0.000 claims 13
- 102200100726 rs61752874 Human genes 0.000 claims 11
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 10
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 8
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 8
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 101100044298 Drosophila melanogaster fand gene Proteins 0.000 claims 7
- 101150064015 FAS gene Proteins 0.000 claims 7
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims 7
- 101100335198 Pneumocystis carinii fol1 gene Proteins 0.000 claims 7
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 7
- 230000035772 mutation Effects 0.000 claims 7
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims 5
- 101150069255 KLRC1 gene Proteins 0.000 claims 5
- 101100404845 Macaca mulatta NKG2A gene Proteins 0.000 claims 5
- 102100022682 NKG2-A/NKG2-B type II integral membrane protein Human genes 0.000 claims 5
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims 5
- 108010004217 Natural Cytotoxicity Triggering Receptor 1 Proteins 0.000 claims 5
- 102100032870 Natural cytotoxicity triggering receptor 1 Human genes 0.000 claims 5
- 230000037430 deletion Effects 0.000 claims 5
- 238000012217 deletion Methods 0.000 claims 5
- -1 Kabat amino acids Chemical class 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 210000000822 natural killer cell Anatomy 0.000 claims 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 3
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 3
- 101001023379 Homo sapiens Lysosome-associated membrane glycoprotein 1 Proteins 0.000 claims 3
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims 3
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 3
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 3
- 102000017578 LAG3 Human genes 0.000 claims 3
- 206010025323 Lymphomas Diseases 0.000 claims 3
- 102100035133 Lysosome-associated membrane glycoprotein 1 Human genes 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 claims 3
- 102220499387 Transcriptional protein SWT1_Q22A_mutation Human genes 0.000 claims 3
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 3
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 3
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 3
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 3
- 239000002246 antineoplastic agent Substances 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 102220540040 Alkaline phosphatase, placental type_R38A_mutation Human genes 0.000 claims 2
- 206010014733 Endometrial cancer Diseases 0.000 claims 2
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 2
- 239000004471 Glycine Substances 0.000 claims 2
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 2
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 102100029193 Low affinity immunoglobulin gamma Fc region receptor III-A Human genes 0.000 claims 2
- 108010004222 Natural Cytotoxicity Triggering Receptor 3 Proteins 0.000 claims 2
- 102100032852 Natural cytotoxicity triggering receptor 3 Human genes 0.000 claims 2
- 102220580198 Non-receptor tyrosine-protein kinase TYK2_L19A_mutation Human genes 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 101710187830 Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 claims 2
- 102100033733 Tumor necrosis factor receptor superfamily member 1B Human genes 0.000 claims 2
- 230000001093 anti-cancer Effects 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 108040006849 interleukin-2 receptor activity proteins Proteins 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
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- 239000000203 mixture Substances 0.000 claims 2
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- 201000011549 stomach cancer Diseases 0.000 claims 2
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- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical group COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- 208000002008 AIDS-Related Lymphoma Diseases 0.000 claims 1
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 102220467418 Acyl-coenzyme A thioesterase MBLAC2_E61Q_mutation Human genes 0.000 claims 1
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000003950 B-cell lymphoma Diseases 0.000 claims 1
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 1
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 1
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- 208000006332 Choriocarcinoma Diseases 0.000 claims 1
- 102220603939 Clathrin heavy chain 1_P65N_mutation Human genes 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000002699 Digestive System Neoplasms Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 108700004922 F42A Proteins 0.000 claims 1
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 1
- 101150046249 Havcr2 gene Proteins 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 101000884298 Homo sapiens CD226 antigen Proteins 0.000 claims 1
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims 1
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 1
- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 claims 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 1
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 1
- 102220604965 Killer cell immunoglobulin-like receptor 3DL1_M23V_mutation Human genes 0.000 claims 1
- 206010023825 Laryngeal cancer Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025312 Lymphoma AIDS related Diseases 0.000 claims 1
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 1
- 102220608429 Mitogen-activated protein kinase kinase kinase kinase 1_E95V_mutation Human genes 0.000 claims 1
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 1
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- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 102220533967 Protein BEX1_E61S_mutation Human genes 0.000 claims 1
- 102220498123 Protein LRATD2_E95S_mutation Human genes 0.000 claims 1
- 102220643014 Protein phosphatase 1A_Q22G_mutation Human genes 0.000 claims 1
- 102220640550 Putative oxidoreductase GLYR1_L19S_mutation Human genes 0.000 claims 1
- 102220495631 Putative uncharacterized protein LOC645739_F42A_mutation Human genes 0.000 claims 1
- 102220494437 Receptor of activated protein C kinase 1_Q22V_mutation Human genes 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 201000000582 Retinoblastoma Diseases 0.000 claims 1
- 208000004337 Salivary Gland Neoplasms Diseases 0.000 claims 1
- 206010061934 Salivary gland cancer Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 102220547809 Serine/threonine-protein kinase B-raf_N88T_mutation Human genes 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 102220603562 TYRO protein tyrosine kinase-binding protein_Q22D_mutation Human genes 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 102220610852 Thialysine N-epsilon-acetyltransferase_L72G_mutation Human genes 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 102000004060 Transforming Growth Factor-beta Type II Receptor Human genes 0.000 claims 1
- 108010082684 Transforming Growth Factor-beta Type II Receptor Proteins 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 206010047741 Vulval cancer Diseases 0.000 claims 1
- 208000004354 Vulvar Neoplasms Diseases 0.000 claims 1
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims 1
- 229960003852 atezolizumab Drugs 0.000 claims 1
- 201000009036 biliary tract cancer Diseases 0.000 claims 1
- 208000020790 biliary tract neoplasm Diseases 0.000 claims 1
- 201000000220 brain stem cancer Diseases 0.000 claims 1
- 102220363900 c.182A>C Human genes 0.000 claims 1
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- 102220344885 c.67A>T Human genes 0.000 claims 1
- 102220350724 c.68T>A Human genes 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 201000007455 central nervous system cancer Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
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- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 208000024558 digestive system cancer Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229950009791 durvalumab Drugs 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 208000024519 eye neoplasm Diseases 0.000 claims 1
- 230000003325 follicular Effects 0.000 claims 1
- 201000003444 follicular lymphoma Diseases 0.000 claims 1
- 201000010231 gastrointestinal system cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000009277 hairy cell leukemia Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 239000000833 heterodimer Substances 0.000 claims 1
- 239000000710 homodimer Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 208000020082 intraepithelial neoplasia Diseases 0.000 claims 1
- 229960005386 ipilimumab Drugs 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 206010023841 laryngeal neoplasm Diseases 0.000 claims 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 1
- 201000005249 lung adenocarcinoma Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 201000005243 lung squamous cell carcinoma Diseases 0.000 claims 1
- 230000000527 lymphocytic effect Effects 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000016847 malignant urinary system neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 208000025113 myeloid leukemia Diseases 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 229960003301 nivolumab Drugs 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 201000008106 ocular cancer Diseases 0.000 claims 1
- 244000309459 oncolytic virus Species 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 229960002621 pembrolizumab Drugs 0.000 claims 1
- 201000002628 peritoneum cancer Diseases 0.000 claims 1
- 230000004962 physiological condition Effects 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 238000002271 resection Methods 0.000 claims 1
- 201000007048 respiratory system cancer Diseases 0.000 claims 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 claims 1
- 102220223852 rs1060502978 Human genes 0.000 claims 1
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- 102220062675 rs786204152 Human genes 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 229950007217 tremelimumab Drugs 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 229950005972 urelumab Drugs 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 201000004435 urinary system cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
- 229950003520 utomilumab Drugs 0.000 claims 1
- 201000005102 vulva cancer Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063047681P | 2020-07-02 | 2020-07-02 | |
| US63/047,681 | 2020-07-02 | ||
| PCT/US2021/040061 WO2022006380A2 (en) | 2020-07-02 | 2021-07-01 | Polypeptides comprising modified il-2 polypeptides and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023532904A JP2023532904A (ja) | 2023-08-01 |
| JP2023532904A5 JP2023532904A5 (https=) | 2024-07-03 |
| JPWO2022006380A5 true JPWO2022006380A5 (https=) | 2024-07-03 |
Family
ID=77127075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022580769A Pending JP2023532904A (ja) | 2020-07-02 | 2021-07-01 | 修飾ｉｌ－２ポリペプチドを含むポリペプチド及びその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20230235005A1 (https=) |
| EP (1) | EP4175979A2 (https=) |
| JP (1) | JP2023532904A (https=) |
| KR (1) | KR20230035076A (https=) |
| CN (1) | CN116615440A (https=) |
| AR (1) | AR122863A1 (https=) |
| AU (1) | AU2021299552A1 (https=) |
| CA (1) | CA3184618A1 (https=) |
| IL (1) | IL299542A (https=) |
| MX (1) | MX2022016532A (https=) |
| TW (1) | TW202216745A (https=) |
| WO (1) | WO2022006380A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4232071A4 (en) | 2020-10-23 | 2024-08-28 | Asher Biotherapeutics, Inc. | FUSIONS WITH CD8 ANTIGEN-BINDING MOLECULES TO MODULATE IMMUNE CELL FUNCTION |
| AU2022275666A1 (en) | 2021-05-19 | 2023-12-07 | Asher Biotherapeutics, Inc. | Il-21 polypeptides and targeted constructs |
| US20250109203A1 (en) * | 2022-01-05 | 2025-04-03 | Inhibrx Biosciences, Inc. | Gamma Delta T-Cell-Targeted Modified IL-2 Polypeptides and Uses Thereof |
| CA3243623A1 (en) * | 2022-02-11 | 2025-01-20 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Immunoconjugated and its use |
| JP2025515470A (ja) * | 2022-04-27 | 2025-05-15 | アシャ バイオセラピューティクス，インク． | サイトカイン融合タンパク質とｃｄ８抗原結合分子の併用 |
| CA3259108A1 (en) | 2022-06-16 | 2023-12-21 | Cephalon Llc | Attenuated Anti-PD1-IL2 Immunoconjugates and Their Uses |
| TW202402784A (zh) * | 2022-07-06 | 2024-01-16 | 中國商科望（上海）生物醫藥科技有限公司 | Il2突變蛋白及其用途 |
| CN116041539B (zh) * | 2022-10-31 | 2023-07-21 | 山东博安生物技术股份有限公司 | Il-2突变体免疫缀合物 |
| EP4662237A1 (en) * | 2023-02-06 | 2025-12-17 | Merck Patent GmbH | Vhh-based nkp46 binders |
| US20250092109A1 (en) | 2023-08-30 | 2025-03-20 | Xilio Development, Inc. | Vhh masked cytokines and methods of use thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| ES2375931T3 (es) | 1997-12-05 | 2012-03-07 | The Scripps Research Institute | Humanización de anticuerpo murino. |
| US7217797B2 (en) | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| PT1678314E (pt) | 2003-10-22 | 2012-11-27 | Keck Graduate Inst | Métodos de síntese de polipéptidos heteromultiméricos em levedura utilizando uma estratégia de conjugação haplóide |
| BRPI0508470A (pt) * | 2004-03-05 | 2007-07-31 | Chiron Corp | sistema de teste in vitro para prever toleráncia do paciente aos agentes terapêuticos |
| CN1961003B (zh) | 2004-03-31 | 2013-03-27 | 健泰科生物技术公司 | 人源化抗TGF-β抗体 |
| WO2015164815A1 (en) * | 2014-04-24 | 2015-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists, partial agonists and antagonists of interleukin-2 |
| KR102687530B1 (ko) * | 2016-05-04 | 2024-07-25 | 암젠 인크 | T-조절 세포의 증식을 위한 인터류킨-2 뮤테인 |
| CN116970059A (zh) * | 2016-12-22 | 2023-10-31 | 库尔生物制药有限公司 | T细胞调节性多聚体多肽及其使用方法 |
| JP7637415B2 (ja) * | 2018-06-22 | 2025-02-28 | キュージーン インコーポレイテッド | インターロイキン－２バリアントおよびその使用方法 |
| US11492384B2 (en) * | 2018-09-17 | 2022-11-08 | Gi Innovation, Inc. | Fusion protein comprising IL-2 protein and CD80 protein, and use thereof |
| KR20210113265A (ko) * | 2019-01-07 | 2021-09-15 | 인히브릭스, 인크. | 변형된 il-2 폴리펩타이드를 포함하는 폴리펩타이드 및 이의 용도 |
| AU2020287373B2 (en) * | 2019-06-05 | 2026-01-29 | Asher Biotherapeutics, Inc. | Fusions of mutant interleukin-2 polypeptides with antigen binding molecules for modulating immune cell function |
-
2021
- 2021-07-01 TW TW110124255A patent/TW202216745A/zh unknown
- 2021-07-01 US US18/002,613 patent/US20230235005A1/en active Pending
- 2021-07-01 EP EP21748720.6A patent/EP4175979A2/en active Pending
- 2021-07-01 CA CA3184618A patent/CA3184618A1/en active Pending
- 2021-07-01 KR KR1020237003798A patent/KR20230035076A/ko active Pending
- 2021-07-01 AU AU2021299552A patent/AU2021299552A1/en active Pending
- 2021-07-01 MX MX2022016532A patent/MX2022016532A/es unknown
- 2021-07-01 AR ARP210101857A patent/AR122863A1/es unknown
- 2021-07-01 JP JP2022580769A patent/JP2023532904A/ja active Pending
- 2021-07-01 CN CN202180053315.0A patent/CN116615440A/zh active Pending
- 2021-07-01 WO PCT/US2021/040061 patent/WO2022006380A2/en not_active Ceased
- 2021-07-01 IL IL299542A patent/IL299542A/en unknown
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