JPWO2020146221A5 - - Google Patents
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- JPWO2020146221A5 JPWO2020146221A5 JP2021538982A JP2021538982A JPWO2020146221A5 JP WO2020146221 A5 JPWO2020146221 A5 JP WO2020146221A5 JP 2021538982 A JP2021538982 A JP 2021538982A JP 2021538982 A JP2021538982 A JP 2021538982A JP WO2020146221 A5 JPWO2020146221 A5 JP WO2020146221A5
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- Prior art keywords
- binding domain
- antigen binding
- polypeptide
- domain binds
- cancer
- Prior art date
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- 239000000427 antigen Substances 0.000 claims 89
- 102000036639 antigens Human genes 0.000 claims 89
- 108091007433 antigens Proteins 0.000 claims 89
- 108090000765 processed proteins & peptides Proteins 0.000 claims 59
- 229920001184 polypeptide Polymers 0.000 claims 57
- 102000004196 processed proteins & peptides Human genes 0.000 claims 57
- 238000006467 substitution reaction Methods 0.000 claims 27
- 108010002350 Interleukin-2 Proteins 0.000 claims 22
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 21
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 21
- 150000001413 amino acids Chemical group 0.000 claims 20
- 210000001744 T-lymphocyte Anatomy 0.000 claims 11
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 10
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 9
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 8
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 101100044298 Drosophila melanogaster fand gene Proteins 0.000 claims 6
- 101150064015 FAS gene Proteins 0.000 claims 6
- 101100335198 Pneumocystis carinii fol1 gene Proteins 0.000 claims 6
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 6
- 230000035772 mutation Effects 0.000 claims 6
- 108010004217 Natural Cytotoxicity Triggering Receptor 1 Proteins 0.000 claims 5
- 102100032870 Natural cytotoxicity triggering receptor 1 Human genes 0.000 claims 5
- 102220503468 Superoxide dismutase [Cu-Zn]_D84S_mutation Human genes 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 102220638990 Beta-enolase_H16A_mutation Human genes 0.000 claims 4
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims 4
- 101150069255 KLRC1 gene Proteins 0.000 claims 4
- -1 Kabat amino acids Chemical class 0.000 claims 4
- 101100404845 Macaca mulatta NKG2A gene Proteins 0.000 claims 4
- 102100022682 NKG2-A/NKG2-B type II integral membrane protein Human genes 0.000 claims 4
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
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- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 3
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 3
- 101001023379 Homo sapiens Lysosome-associated membrane glycoprotein 1 Proteins 0.000 claims 3
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims 3
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 3
- 102000017578 LAG3 Human genes 0.000 claims 3
- 102100035133 Lysosome-associated membrane glycoprotein 1 Human genes 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 claims 3
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 3
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 3
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 3
- 230000001093 anti-cancer Effects 0.000 claims 3
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- 206010014733 Endometrial cancer Diseases 0.000 claims 2
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- 239000004471 Glycine Substances 0.000 claims 2
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- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 2
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- 102220498123 Protein LRATD2_E95S_mutation Human genes 0.000 claims 2
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- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical group COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- 208000002008 AIDS-Related Lymphoma Diseases 0.000 claims 1
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- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
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- 208000009458 Carcinoma in Situ Diseases 0.000 claims 1
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- 102220603939 Clathrin heavy chain 1_P65N_mutation Human genes 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
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- 108700004922 F42A Proteins 0.000 claims 1
- 102220606752 Gap junction beta-1 protein_H16P_mutation Human genes 0.000 claims 1
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- 102100035943 HERV-H LTR-associating protein 2 Human genes 0.000 claims 1
- 101150046249 Havcr2 gene Proteins 0.000 claims 1
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- 101000884279 Homo sapiens CD276 antigen Proteins 0.000 claims 1
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- 101001021491 Homo sapiens HERV-H LTR-associating protein 2 Proteins 0.000 claims 1
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims 1
- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 claims 1
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 1
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims 1
- 101000955999 Homo sapiens V-set domain-containing T-cell activation inhibitor 1 Proteins 0.000 claims 1
- 101000666896 Homo sapiens V-type immunoglobulin domain-containing suppressor of T-cell activation Proteins 0.000 claims 1
- 102220604965 Killer cell immunoglobulin-like receptor 3DL1_M23V_mutation Human genes 0.000 claims 1
- 206010023825 Laryngeal cancer Diseases 0.000 claims 1
- 102100029193 Low affinity immunoglobulin gamma Fc region receptor III-A Human genes 0.000 claims 1
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- 206010025312 Lymphoma AIDS related Diseases 0.000 claims 1
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- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 1
- 102220608429 Mitogen-activated protein kinase kinase kinase kinase 1_E95V_mutation Human genes 0.000 claims 1
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- 102220505697 Palmitoyl-protein thioesterase 1_Y45F_mutation Human genes 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
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- 102220495631 Putative uncharacterized protein LOC645739_F42A_mutation Human genes 0.000 claims 1
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- 208000004337 Salivary Gland Neoplasms Diseases 0.000 claims 1
- 206010061934 Salivary gland cancer Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
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- 102220503469 Superoxide dismutase [Cu-Zn]_D84A_mutation Human genes 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
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- 102220610852 Thialysine N-epsilon-acetyltransferase_L72G_mutation Human genes 0.000 claims 1
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- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 102100038929 V-set domain-containing T-cell activation inhibitor 1 Human genes 0.000 claims 1
- 102100038282 V-type immunoglobulin domain-containing suppressor of T-cell activation Human genes 0.000 claims 1
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- IJJVMEJXYNJXOJ-UHFFFAOYSA-N fluquinconazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1C(=O)C2=CC(F)=CC=C2N=C1N1C=NC=N1 IJJVMEJXYNJXOJ-UHFFFAOYSA-N 0.000 claims 1
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024185692A JP2025013911A (ja) | 2019-01-07 | 2024-10-22 | 修飾ｉｌ－２ポリペプチドを含むポリペプチド及びその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962789075P | 2019-01-07 | 2019-01-07 | |
| US62/789,075 | 2019-01-07 | ||
| PCT/US2020/012296 WO2020146221A1 (en) | 2019-01-07 | 2020-01-06 | Polypeptides comprising modified il-2 polypeptides and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024185692A Division JP2025013911A (ja) | 2019-01-07 | 2024-10-22 | 修飾ｉｌ－２ポリペプチドを含むポリペプチド及びその使用 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022516557A JP2022516557A (ja) | 2022-02-28 |
| JPWO2020146221A5 true JPWO2020146221A5 (https=) | 2023-01-19 |
| JP2022516557A5 JP2022516557A5 (https=) | 2023-01-19 |
| JP7594161B2 JP7594161B2 (ja) | 2024-12-04 |
Family
ID=69374426
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021538982A Active JP7594161B2 (ja) | 2019-01-07 | 2020-01-06 | 修飾ｉｌ－２ポリペプチドを含むポリペプチド及びその使用 |
| JP2024185692A Pending JP2025013911A (ja) | 2019-01-07 | 2024-10-22 | 修飾ｉｌ－２ポリペプチドを含むポリペプチド及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024185692A Pending JP2025013911A (ja) | 2019-01-07 | 2024-10-22 | 修飾ｉｌ－２ポリペプチドを含むポリペプチド及びその使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20220089667A1 (https=) |
| EP (1) | EP3908596A1 (https=) |
| JP (2) | JP7594161B2 (https=) |
| KR (1) | KR20210113265A (https=) |
| CN (1) | CN113924311A (https=) |
| AR (1) | AR117770A1 (https=) |
| AU (2) | AU2020206672B2 (https=) |
| BR (1) | BR112021012294A2 (https=) |
| CA (1) | CA3125529A1 (https=) |
| CL (1) | CL2021001779A1 (https=) |
| IL (1) | IL284633A (https=) |
| MX (1) | MX2021008147A (https=) |
| SG (1) | SG11202106700WA (https=) |
| TW (1) | TWI874345B (https=) |
| WO (1) | WO2020146221A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019028419A1 (en) | 2017-08-03 | 2019-02-07 | Synthorx, Inc. | CYTOKINE CONJUGATES FOR THE TREATMENT OF PROLIFERATIVE AND INFECTIOUS DISEASES |
| EP3746095A4 (en) | 2018-02-01 | 2021-04-21 | Nkmax Co., Ltd. | Method of producing natural killer cells and composition for treating cancer |
| ES3059360T3 (en) | 2018-11-08 | 2026-03-19 | Synthorx Inc | Interleukin 10 conjugates and uses thereof |
| KR20260039812A (ko) | 2019-02-06 | 2026-03-20 | 신톡스, 인크. | Il-2 콘쥬게이트 및 이의 사용 방법 |
| CN114555632A (zh) | 2019-08-23 | 2022-05-27 | 新索思股份有限公司 | Il-15缀合物及其用途 |
| MX2022002740A (es) | 2019-09-10 | 2022-03-25 | Synthorx Inc | Conjugados de il-2 y metodos de uso para tratar enfermedades autoinmunes. |
| KR102313505B1 (ko) * | 2020-06-30 | 2021-10-18 | (주)지아이이노베이션 | 항-lag-3 항체 및 il-2를 포함하는 융합단백질 및 이의 용도 |
| TW202216745A (zh) * | 2020-07-02 | 2022-05-01 | 美商英伊布里克斯公司 | 包含經修飾ｉｌ－２多肽之多肽及其用途 |
| EP4232071A4 (en) | 2020-10-23 | 2024-08-28 | Asher Biotherapeutics, Inc. | FUSIONS WITH CD8 ANTIGEN-BINDING MOLECULES TO MODULATE IMMUNE CELL FUNCTION |
| US20220144956A1 (en) * | 2020-11-06 | 2022-05-12 | Xencor, Inc. | HETERODIMERIC ANTIBODIES THAT BIND TGFbetaRII |
| WO2022115865A2 (en) | 2020-11-25 | 2022-06-02 | Xilio Development, Inc. | Tumor-specific cleavable linkers |
| CN116829194A (zh) * | 2020-12-09 | 2023-09-29 | 亚设生物治疗公司 | 用于工程化细胞疗法的靶向细胞因子构建体 |
| CN112979782B (zh) * | 2021-03-08 | 2023-07-18 | 深圳市乐土生物医药有限公司 | 一种多肽及其用途 |
| EP4314033A4 (en) * | 2021-03-31 | 2025-04-23 | Anwita Biosciences, Inc. | FUSION PROTEINS, PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC APPLICATIONS |
| TW202309102A (zh) * | 2021-07-20 | 2023-03-01 | 美商英伊布里克斯公司 | 靶向cd8之經修飾il-2多肽及其用途 |
| WO2023004304A1 (en) * | 2021-07-20 | 2023-01-26 | Inhibrx, Inc. | Cd8-binding polypeptides and uses thereof |
| EP4395895A1 (en) * | 2021-08-30 | 2024-07-10 | Inhibrx, Inc. | Nkp46-binding polypeptides and uses thereof |
| US20240376198A1 (en) * | 2021-08-30 | 2024-11-14 | Inhibrx, Inc. | NKp46-Targeted Modified IL-2 Polypeptides and Uses Thereof |
| JP2024536840A (ja) * | 2021-09-26 | 2024-10-08 | ウーシー バイオロジクス アイルランド リミテッド | Ｉｌ－２バリアント及びその融合タンパク質 |
| US20250109203A1 (en) * | 2022-01-05 | 2025-04-03 | Inhibrx Biosciences, Inc. | Gamma Delta T-Cell-Targeted Modified IL-2 Polypeptides and Uses Thereof |
| EP4561632A2 (en) * | 2022-07-28 | 2025-06-04 | Proviva Therapeutics (Hong Kong) Limited | Il-2 procytokine antibody fusion proteins |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| ES2375931T3 (es) | 1997-12-05 | 2012-03-07 | The Scripps Research Institute | Humanización de anticuerpo murino. |
| PT1454138E (pt) * | 2001-12-04 | 2012-03-28 | Merck Patent Gmbh | Imunocitoquinas com seletividade modulada |
| US7217797B2 (en) | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| PT1678314E (pt) | 2003-10-22 | 2012-11-27 | Keck Graduate Inst | Métodos de síntese de polipéptidos heteromultiméricos em levedura utilizando uma estratégia de conjugação haplóide |
| CN1930300A (zh) * | 2004-03-05 | 2007-03-14 | 希龙公司 | 预测患者治疗药物耐受性的体外试验系统 |
| BRPI0508470A (pt) * | 2004-03-05 | 2007-07-31 | Chiron Corp | sistema de teste in vitro para prever toleráncia do paciente aos agentes terapêuticos |
| CN1961003B (zh) | 2004-03-31 | 2013-03-27 | 健泰科生物技术公司 | 人源化抗TGF-β抗体 |
| CN102101885B (zh) * | 2010-09-01 | 2013-06-05 | 南京发士达生物科技有限公司 | 低诱导抑制性t细胞的人白细胞介素ⅱ突变体及其用途 |
| HUE029139T2 (hu) * | 2011-02-10 | 2017-02-28 | Roche Glycart Ag | Mutáns interleukin-2 polipeptidek |
| EP3795215A1 (en) * | 2012-05-30 | 2021-03-24 | Chugai Seiyaku Kabushiki Kaisha | Target tissue-specific antigen-binding molecule |
| KR102042246B1 (ko) * | 2014-02-06 | 2019-11-28 | 에프. 호프만-라 로슈 아게 | 인터류킨-2 융합 단백질 및 이의 용도 |
| WO2017121758A1 (en) * | 2016-01-11 | 2017-07-20 | Universität Zürich | Combination therapy comprising a superagonistic antibody against interleukin-2 and a checkpoint blockade agent |
| KR102687530B1 (ko) * | 2016-05-04 | 2024-07-25 | 암젠 인크 | T-조절 세포의 증식을 위한 인터류킨-2 뮤테인 |
| IL269000B2 (en) * | 2017-03-15 | 2024-06-01 | Cue Biopharma Inc | Methods for modulating an immune response |
| JP7148539B2 (ja) * | 2017-04-03 | 2022-10-05 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 免疫抱合体 |
| TWI690538B (zh) * | 2017-04-05 | 2020-04-11 | 瑞士商赫孚孟拉羅股份公司 | 特異性結合至pd1至lag3的雙特異性抗體 |
| JP2020521452A (ja) * | 2017-05-24 | 2020-07-27 | パンディオン・セラピューティクス・インコーポレイテッド | 標的化免疫寛容 |
| AU2018287317B2 (en) * | 2017-06-19 | 2024-06-20 | Medicenna Therapeutics Inc. | Uses and methods for IL-2 superagonists, agonists, and fusions thereof |
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2020
- 2020-01-06 KR KR1020217024431A patent/KR20210113265A/ko active Pending
- 2020-01-06 CA CA3125529A patent/CA3125529A1/en active Pending
- 2020-01-06 TW TW109100336A patent/TWI874345B/zh active
- 2020-01-06 JP JP2021538982A patent/JP7594161B2/ja active Active
- 2020-01-06 CN CN202080018011.6A patent/CN113924311A/zh active Pending
- 2020-01-06 EP EP20702547.9A patent/EP3908596A1/en active Pending
- 2020-01-06 MX MX2021008147A patent/MX2021008147A/es unknown
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- 2020-01-06 AU AU2020206672A patent/AU2020206672B2/en active Active
- 2020-01-06 WO PCT/US2020/012296 patent/WO2020146221A1/en not_active Ceased
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2021
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2024
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2025
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