TW202216745A - 包含經修飾ｉｌ－２多肽之多肽及其用途 - Google Patents
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| EP4232071A4 (en) | 2020-10-23 | 2024-08-28 | Asher Biotherapeutics, Inc. | FUSIONS WITH CD8 ANTIGEN-BINDING MOLECULES TO MODULATE IMMUNE CELL FUNCTION |
| AU2022275666A1 (en) | 2021-05-19 | 2023-12-07 | Asher Biotherapeutics, Inc. | Il-21 polypeptides and targeted constructs |
| US20250109203A1 (en) * | 2022-01-05 | 2025-04-03 | Inhibrx Biosciences, Inc. | Gamma Delta T-Cell-Targeted Modified IL-2 Polypeptides and Uses Thereof |
| CA3243623A1 (en) * | 2022-02-11 | 2025-01-20 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Immunoconjugated and its use |
| JP2025515470A (ja) * | 2022-04-27 | 2025-05-15 | アシャ バイオセラピューティクス，インク． | サイトカイン融合タンパク質とｃｄ８抗原結合分子の併用 |
| CA3259108A1 (en) | 2022-06-16 | 2023-12-21 | Cephalon Llc | Attenuated Anti-PD1-IL2 Immunoconjugates and Their Uses |
| TW202402784A (zh) * | 2022-07-06 | 2024-01-16 | 中國商科望（上海）生物醫藥科技有限公司 | Il2突變蛋白及其用途 |
| CN116041539B (zh) * | 2022-10-31 | 2023-07-21 | 山东博安生物技术股份有限公司 | Il-2突变体免疫缀合物 |
| EP4662237A1 (en) * | 2023-02-06 | 2025-12-17 | Merck Patent GmbH | Vhh-based nkp46 binders |
| US20250092109A1 (en) | 2023-08-30 | 2025-03-20 | Xilio Development, Inc. | Vhh masked cytokines and methods of use thereof |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| ES2375931T3 (es) | 1997-12-05 | 2012-03-07 | The Scripps Research Institute | Humanización de anticuerpo murino. |
| US7217797B2 (en) | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| PT1678314E (pt) | 2003-10-22 | 2012-11-27 | Keck Graduate Inst | Métodos de síntese de polipéptidos heteromultiméricos em levedura utilizando uma estratégia de conjugação haplóide |
| BRPI0508470A (pt) * | 2004-03-05 | 2007-07-31 | Chiron Corp | sistema de teste in vitro para prever toleráncia do paciente aos agentes terapêuticos |
| CN1961003B (zh) | 2004-03-31 | 2013-03-27 | 健泰科生物技术公司 | 人源化抗TGF-β抗体 |
| WO2015164815A1 (en) * | 2014-04-24 | 2015-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists, partial agonists and antagonists of interleukin-2 |
| KR102687530B1 (ko) * | 2016-05-04 | 2024-07-25 | 암젠 인크 | T-조절 세포의 증식을 위한 인터류킨-2 뮤테인 |
| CN116970059A (zh) * | 2016-12-22 | 2023-10-31 | 库尔生物制药有限公司 | T细胞调节性多聚体多肽及其使用方法 |
| JP7637415B2 (ja) * | 2018-06-22 | 2025-02-28 | キュージーン インコーポレイテッド | インターロイキン－２バリアントおよびその使用方法 |
| US11492384B2 (en) * | 2018-09-17 | 2022-11-08 | Gi Innovation, Inc. | Fusion protein comprising IL-2 protein and CD80 protein, and use thereof |
| KR20210113265A (ko) * | 2019-01-07 | 2021-09-15 | 인히브릭스, 인크. | 변형된 il-2 폴리펩타이드를 포함하는 폴리펩타이드 및 이의 용도 |
| AU2020287373B2 (en) * | 2019-06-05 | 2026-01-29 | Asher Biotherapeutics, Inc. | Fusions of mutant interleukin-2 polypeptides with antigen binding molecules for modulating immune cell function |
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- 2021-07-01 US US18/002,613 patent/US20230235005A1/en active Pending
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| WO2022006380A3 (en) | 2022-02-24 |
| CA3184618A1 (en) | 2022-01-06 |
| KR20230035076A (ko) | 2023-03-10 |
| US20230235005A1 (en) | 2023-07-27 |
| IL299542A (en) | 2023-02-01 |
| AU2021299552A1 (en) | 2023-02-02 |
| WO2022006380A2 (en) | 2022-01-06 |
| JP2023532904A (ja) | 2023-08-01 |
| MX2022016532A (es) | 2023-04-12 |
| AR122863A1 (es) | 2022-10-12 |
| CN116615440A (zh) | 2023-08-18 |
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