JP2023531517A - ３．アルファ．－ヒドロキシ、１７．ベータ．－ｃ（ｏ）－ｎ－アリール置換神経活性ステロイド及びそれらの組成物 - Google Patents

３．アルファ．－ヒドロキシ、１７．ベータ．－ｃ（ｏ）－ｎ－アリール置換神経活性ステロイド及びそれらの組成物 Download PDF

Info

Publication number
JP2023531517A
JP2023531517A JP2022579725A JP2022579725A JP2023531517A JP 2023531517 A JP2023531517 A JP 2023531517A JP 2022579725 A JP2022579725 A JP 2022579725A JP 2022579725 A JP2022579725 A JP 2022579725A JP 2023531517 A JP2023531517 A JP 2023531517A
Authority
JP
Japan
Prior art keywords
compound
pharmaceutically acceptable
unsubstituted
acceptable salt
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022579725A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023531517A5 (https=
Inventor
ビンソン ハン，
マリア ヘスス ブランコ－ピヤド，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sage Therapeutics LLC
Original Assignee
Sage Therapeutics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sage Therapeutics LLC filed Critical Sage Therapeutics LLC
Publication of JP2023531517A publication Critical patent/JP2023531517A/ja
Publication of JP2023531517A5 publication Critical patent/JP2023531517A5/ja
Priority to JP2026000046A priority Critical patent/JP2026042854A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
JP2022579725A 2020-06-24 2021-06-23 ３．アルファ．－ヒドロキシ、１７．ベータ．－ｃ（ｏ）－ｎ－アリール置換神経活性ステロイド及びそれらの組成物 Pending JP2023531517A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2026000046A JP2026042854A (ja) 2020-06-24 2026-01-04 ３．アルファ．－ヒドロキシ、１７．ベータ．－ｃ（ｏ）－ｎ－アリール置換神経活性ステロイド及びそれらの組成物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063043641P 2020-06-24 2020-06-24
US63/043,641 2020-06-24
PCT/US2021/038661 WO2021262836A1 (en) 2020-06-24 2021-06-23 3.alpha.-hydroxy, 17.beta.-c(o)-n-aryl substituted neuroactive steroids and compositions thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2026000046A Division JP2026042854A (ja) 2020-06-24 2026-01-04 ３．アルファ．－ヒドロキシ、１７．ベータ．－ｃ（ｏ）－ｎ－アリール置換神経活性ステロイド及びそれらの組成物

Publications (2)

Publication Number Publication Date
JP2023531517A true JP2023531517A (ja) 2023-07-24
JP2023531517A5 JP2023531517A5 (https=) 2024-07-01

Family

ID=77265178

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022579725A Pending JP2023531517A (ja) 2020-06-24 2021-06-23 ３．アルファ．－ヒドロキシ、１７．ベータ．－ｃ（ｏ）－ｎ－アリール置換神経活性ステロイド及びそれらの組成物
JP2026000046A Pending JP2026042854A (ja) 2020-06-24 2026-01-04 ３．アルファ．－ヒドロキシ、１７．ベータ．－ｃ（ｏ）－ｎ－アリール置換神経活性ステロイド及びそれらの組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2026000046A Pending JP2026042854A (ja) 2020-06-24 2026-01-04 ３．アルファ．－ヒドロキシ、１７．ベータ．－ｃ（ｏ）－ｎ－アリール置換神経活性ステロイド及びそれらの組成物

Country Status (11)

Country Link
US (1) US20230250129A1 (https=)
EP (1) EP4172171A1 (https=)
JP (2) JP2023531517A (https=)
CN (1) CN115768781A (https=)
AR (1) AR122733A1 (https=)
AU (1) AU2021296846A1 (https=)
CA (1) CA3183248A1 (https=)
IL (1) IL299176A (https=)
MX (3) MX2022016343A (https=)
TW (1) TW202233198A (https=)
WO (1) WO2021262836A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2882708A1 (en) 2012-08-21 2014-02-27 Sage Therapeutics, Inc. Methods of treating epilepsy or status epilepticus
KR102396328B1 (ko) 2013-04-17 2022-05-10 세이지 테라퓨틱스, 인크. 19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법
US10246482B2 (en) 2014-06-18 2019-04-02 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
WO2016082789A1 (en) 2014-11-27 2016-06-02 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
EP3504189A1 (en) 2016-08-23 2019-07-03 Sage Therapeutics, Inc. A crystalline 19-nor c3, 3-disubstituted c21-n-pyrazolyl steroid
MA51046A (fr) 2017-12-08 2021-03-17 Sage Therapeutics Inc Dérivés de 21-[4-cyano-pyrazol-1-yl]-19-nor-pregan-3. alpha-ol-20-one deutérés pour le traitement de troubles du snc
EP4321519B1 (en) 2018-10-12 2026-04-08 Sage Therapeutics, LLC Neuroactive steroids substituted in position 10 with a cyclic group for use in the treatment of cns disorders
KR20250174100A (ko) 2018-12-05 2025-12-11 세이지 테라퓨틱스, 인크. 신경활성 스테로이드 및 이의 사용 방법
EP4711377A1 (en) * 2023-05-11 2026-03-18 Shujing Biopharma Co., Ltd Steroid compound, preparation method therefor, and use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019126741A1 (en) * 2017-12-22 2019-06-27 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
JP2019520416A (ja) * 2016-07-11 2019-07-18 セージ セラピューティクス， インコーポレイテッド Ｃ１７、ｃ２０、およびｃ２１置換神経刺激性ステロイドおよびそれらの使用方法
WO2019154247A1 (zh) * 2018-02-11 2019-08-15 江苏豪森药业集团有限公司 甾族类衍生物调节剂、其制备方法和应用
WO2020132504A1 (en) * 2018-12-21 2020-06-25 Sage Therapeutics, Inc. 3.alpha.-hydroxy-17.beta.-amide neuroactive steroids and compositions thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019520416A (ja) * 2016-07-11 2019-07-18 セージ セラピューティクス， インコーポレイテッド Ｃ１７、ｃ２０、およびｃ２１置換神経刺激性ステロイドおよびそれらの使用方法
WO2019126741A1 (en) * 2017-12-22 2019-06-27 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
WO2019154247A1 (zh) * 2018-02-11 2019-08-15 江苏豪森药业集团有限公司 甾族类衍生物调节剂、其制备方法和应用
WO2020132504A1 (en) * 2018-12-21 2020-06-25 Sage Therapeutics, Inc. 3.alpha.-hydroxy-17.beta.-amide neuroactive steroids and compositions thereof

Also Published As

Publication number Publication date
AR122733A1 (es) 2022-10-05
CA3183248A1 (en) 2021-12-30
WO2021262836A1 (en) 2021-12-30
US20230250129A1 (en) 2023-08-10
MX2024008998A (es) 2024-07-30
MX2022016343A (es) 2023-03-06
IL299176A (en) 2023-02-01
CN115768781A (zh) 2023-03-07
MX2024008999A (es) 2024-07-30
TW202233198A (zh) 2022-09-01
AU2021296846A1 (en) 2022-12-15
EP4172171A1 (en) 2023-05-03
JP2026042854A (ja) 2026-03-11

Similar Documents

Publication Publication Date Title
JP7670626B2 (ja) 神経刺激性ステロイド及びその組成物
JP7670632B2 (ja) Ｃｎｓ障害を治療するための組成物及び方法
JP2023531517A (ja) ３．アルファ．－ヒドロキシ、１７．ベータ．－ｃ（ｏ）－ｎ－アリール置換神経活性ステロイド及びそれらの組成物
TWI892697B (zh) 神經活性類固醇及其組合物
JP7754725B2 (ja) Ｃｎｓ障害を治療するための組成物及び方法
JP2024114787A (ja) Ｃ１７、ｃ２０、およびｃ２１置換神経刺激性ステロイドおよびそれらの使用方法
JP7817179B2 (ja) 神経刺激性ステロイド及びその使用方法
JP7787635B2 (ja) Ｃｎｓ障害を治療するための組成物及び方法
JP2021510695A (ja) ＣＮＳ障害の処置における使用のためのアザ、オキサ、およびチア−プレグナン−２０−オン−３α−オール化合物
JP2023550653A (ja) Ｃｎｓの障害を治療するための組成物及び方法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240621

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20240621

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20250804

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20251031

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20260104

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20260402