JP2023529011A - インデン化合物、その医薬組成物、及びそれらの治療応用 - Google Patents
インデン化合物、その医薬組成物、及びそれらの治療応用 Download PDFInfo
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- JP2023529011A JP2023529011A JP2022576471A JP2022576471A JP2023529011A JP 2023529011 A JP2023529011 A JP 2023529011A JP 2022576471 A JP2022576471 A JP 2022576471A JP 2022576471 A JP2022576471 A JP 2022576471A JP 2023529011 A JP2023529011 A JP 2023529011A
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- inden
- fluoro
- phenyl
- methylidene
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- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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| US202063038737P | 2020-06-12 | 2020-06-12 | |
| US63/038,737 | 2020-06-12 | ||
| PCT/CN2021/099626 WO2021249529A1 (en) | 2020-06-12 | 2021-06-11 | Indene compounds, pharmaceutical compositions thereof, and their therapeutic applications |
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| JP2023529011A true JP2023529011A (ja) | 2023-07-06 |
| JP2023529011A5 JP2023529011A5 (https=) | 2024-09-24 |
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| CN117916215A (zh) * | 2021-05-15 | 2024-04-19 | 藤济(厦门)生物医药科技有限公司 | 茚化合物、其药物组合物及其治疗应用 |
| CN120513226A (zh) * | 2022-11-16 | 2025-08-19 | 藤济(厦门)生物医药科技有限公司 | 茚化合物、其药物组合物及其治疗应用 |
| CN116589404A (zh) * | 2023-04-24 | 2023-08-15 | 华南理工大学 | 一种靶向β淀粉样蛋白的光敏剂及其制备方法与应用 |
| WO2025051192A1 (en) * | 2023-09-06 | 2025-03-13 | Nucmito Pharmaceuticals Company Limited | Rxr-alpha modulators for treating malignancy |
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| JPH10505336A (ja) * | 1994-07-21 | 1998-05-26 | イーライ・リリー・アンド・カンパニー | インデンsPLA▲下2▼インヒビター |
| JP2001517707A (ja) * | 1997-09-26 | 2001-10-09 | イーライ・リリー・アンド・カンパニー | 嚢胞性繊維症の処置方法 |
| JP2002511852A (ja) * | 1997-05-07 | 2002-04-16 | スージェン・インコーポレーテッド | 蛋白質キナーゼ活性の調節剤としての2−インドリノン誘導体 |
| DE10163426A1 (de) * | 2001-12-21 | 2003-07-03 | Max Planck Gesellschaft | Pharmakologisch wirksame Inden-Derivate |
| JP2011509988A (ja) * | 2008-01-18 | 2011-03-31 | オキサジェン リミテッド | Crth2アンタゴニスト活性を有する化合物 |
| JP2013533212A (ja) * | 2010-05-06 | 2013-08-22 | サンフォード−バーナム メディカル リサーチ インスティテュート | レチノイド受容体に選択的な経路に関する方法および組成物 |
-
2021
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- 2021-06-11 TW TW110121344A patent/TW202214555A/zh unknown
- 2021-06-11 IL IL298984A patent/IL298984A/en unknown
- 2021-06-11 WO PCT/CN2021/099626 patent/WO2021249529A1/en not_active Ceased
- 2021-06-11 JP JP2022576471A patent/JP2023529011A/ja active Pending
- 2021-06-11 AU AU2021287932A patent/AU2021287932A1/en active Pending
- 2021-06-11 KR KR1020237001096A patent/KR20230024976A/ko active Pending
- 2021-06-11 EP EP21822474.9A patent/EP4165009A4/en active Pending
- 2021-06-11 CN CN202180055583.6A patent/CN116472034B/zh active Active
- 2021-06-11 CA CA3182036A patent/CA3182036A1/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10505336A (ja) * | 1994-07-21 | 1998-05-26 | イーライ・リリー・アンド・カンパニー | インデンsPLA▲下2▼インヒビター |
| JP2002511852A (ja) * | 1997-05-07 | 2002-04-16 | スージェン・インコーポレーテッド | 蛋白質キナーゼ活性の調節剤としての2−インドリノン誘導体 |
| JP2001517707A (ja) * | 1997-09-26 | 2001-10-09 | イーライ・リリー・アンド・カンパニー | 嚢胞性繊維症の処置方法 |
| DE10163426A1 (de) * | 2001-12-21 | 2003-07-03 | Max Planck Gesellschaft | Pharmakologisch wirksame Inden-Derivate |
| JP2011509988A (ja) * | 2008-01-18 | 2011-03-31 | オキサジェン リミテッド | Crth2アンタゴニスト活性を有する化合物 |
| JP2013533212A (ja) * | 2010-05-06 | 2013-08-22 | サンフォード−バーナム メディカル リサーチ インスティテュート | レチノイド受容体に選択的な経路に関する方法および組成物 |
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| LIU, S.: ""The RXRα-mediated anti-inflammatory effect of sulindac analog K-80003 and the underlying molecula", CHINESE DOCTRAL DISSERTATIONS & MASTER’S THESES FULL-TEXT DATABASE (MASTER) MEDICINE AND HEALTH SCI, JPN6025024874, 15 June 2019 (2019-06-15), ISSN: 0005625417 * |
| ZHOU, X. ET AL.: ""Sulindac has strong antifibrotic effects by suppressing STAT3-related miR-21"", JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 19, no. 5, JPN6025024875, 2015, pages 1103 - 1113, ISSN: 0005625418 * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20230024976A (ko) | 2023-02-21 |
| EP4165009A1 (en) | 2023-04-19 |
| IL298984A (en) | 2023-02-01 |
| AU2021287932A1 (en) | 2023-02-02 |
| CN116472034B (zh) | 2026-04-17 |
| CA3182036A1 (en) | 2021-12-16 |
| WO2021249529A1 (en) | 2021-12-16 |
| CN116472034A (zh) | 2023-07-21 |
| EP4165009A4 (en) | 2024-10-02 |
| TW202214555A (zh) | 2022-04-16 |
| US20230234909A1 (en) | 2023-07-27 |
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