JP2023526059A5 - - Google Patents

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Publication number
JP2023526059A5
JP2023526059A5 JP2022568830A JP2022568830A JP2023526059A5 JP 2023526059 A5 JP2023526059 A5 JP 2023526059A5 JP 2022568830 A JP2022568830 A JP 2022568830A JP 2022568830 A JP2022568830 A JP 2022568830A JP 2023526059 A5 JP2023526059 A5 JP 2023526059A5
Authority
JP
Japan
Application number
JP2022568830A
Other languages
Japanese (ja)
Other versions
JP2023526059A (ja
JPWO2021231854A5 (https=
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/032438 external-priority patent/WO2021231854A1/en
Publication of JP2023526059A publication Critical patent/JP2023526059A/ja
Publication of JP2023526059A5 publication Critical patent/JP2023526059A5/ja
Publication of JPWO2021231854A5 publication Critical patent/JPWO2021231854A5/ja
Pending legal-status Critical Current

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JP2022568830A 2020-05-14 2021-05-14 mRNA治療薬及びエフェクター分子を含むLNP組成物 Pending JP2023526059A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063024862P 2020-05-14 2020-05-14
US63/024,862 2020-05-14
US202163183119P 2021-05-03 2021-05-03
US63/183,119 2021-05-03
PCT/US2021/032438 WO2021231854A1 (en) 2020-05-14 2021-05-14 Lnp compositions comprising an mrna therapeutic and an effector molecule

Publications (3)

Publication Number Publication Date
JP2023526059A JP2023526059A (ja) 2023-06-20
JP2023526059A5 true JP2023526059A5 (https=) 2024-05-24
JPWO2021231854A5 JPWO2021231854A5 (https=) 2024-05-24

Family

ID=76284222

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022568830A Pending JP2023526059A (ja) 2020-05-14 2021-05-14 mRNA治療薬及びエフェクター分子を含むLNP組成物

Country Status (6)

Country Link
US (1) US20230173104A1 (https=)
EP (1) EP4149435A1 (https=)
JP (1) JP2023526059A (https=)
AU (1) AU2021270587A1 (https=)
CA (1) CA3182920A1 (https=)
WO (1) WO2021231854A1 (https=)

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CN115869332A (zh) * 2022-10-27 2023-03-31 北京新合睿恩生物医疗科技有限公司 递送至体内后在肝脏少表达的mRNA药物及其制备方法
EP4637786A2 (en) * 2022-12-22 2025-10-29 ModernaTX, Inc. Small nuclear ribonucleoprotein 13 polypeptides, polynucleotides, and uses thereof
US12311033B2 (en) 2023-05-31 2025-05-27 Capstan Therapeutics, Inc. Lipid nanoparticle formulations and compositions
WO2025116441A1 (ko) * 2023-11-30 2025-06-05 주식회사 레나임 골관절염의 예방 또는 치료용 약제학적 조성물
WO2025255510A1 (en) * 2024-06-07 2025-12-11 The University Of Chicago Systems and methods for modulating rna

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GB8613481D0 (en) 1986-06-04 1986-07-09 Diatech Ltd Translation of mrna
JPH09505474A (ja) 1993-11-26 1997-06-03 ブリテイツシユ・テクノロジー・グループ・リミテツド 翻訳エンハンサーdna
US5824497A (en) 1995-02-10 1998-10-20 Mcmaster University High efficiency translation of mRNA molecules
EP2390331B1 (en) 2001-09-28 2018-04-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. MicroRNA molecules
US20050222064A1 (en) 2002-02-20 2005-10-06 Sirna Therapeutics, Inc. Polycationic compositions for cellular delivery of polynucleotides
US7683036B2 (en) 2003-07-31 2010-03-23 Regulus Therapeutics Inc. Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
DE102005046490A1 (de) 2005-09-28 2007-03-29 Johannes-Gutenberg-Universität Mainz Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen
DK2205618T3 (en) 2007-09-26 2017-02-20 Intrexon Corp SYNTHETIC 5 'NON-TRANSLATED REGIONS, EXPRESSION VECTORS AND PROCEDURES FOR INCREASING TRANSGENIC EXPRESSION
CA2722183C (en) 2008-04-25 2018-09-18 Northwestern University Nanostructures suitable for sequestering cholesterol and other molecules
US9217155B2 (en) * 2008-05-28 2015-12-22 University Of Massachusetts Isolation of novel AAV'S and uses thereof
PL215513B1 (pl) 2008-06-06 2013-12-31 Univ Warszawski Nowe boranofosforanowe analogi dinukleotydów, ich zastosowanie, czasteczka RNA, sposób otrzymywania RNA oraz sposób otrzymywania peptydów lub bialka
MX342785B (es) 2009-06-10 2016-10-12 Alnylam Pharmaceuticals Inc Formulacion mejorada de lipido.
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