JP2023526059A5 - - Google Patents
Info
- Publication number
- JP2023526059A5 JP2023526059A5 JP2022568830A JP2022568830A JP2023526059A5 JP 2023526059 A5 JP2023526059 A5 JP 2023526059A5 JP 2022568830 A JP2022568830 A JP 2022568830A JP 2022568830 A JP2022568830 A JP 2022568830A JP 2023526059 A5 JP2023526059 A5 JP 2023526059A5
- Authority
- JP
- Japan
- Prior art keywords
- polynucleotide
- lnp
- peg
- composition
- lipid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063024862P | 2020-05-14 | 2020-05-14 | |
| US63/024,862 | 2020-05-14 | ||
| US202163183119P | 2021-05-03 | 2021-05-03 | |
| US63/183,119 | 2021-05-03 | ||
| PCT/US2021/032438 WO2021231854A1 (en) | 2020-05-14 | 2021-05-14 | Lnp compositions comprising an mrna therapeutic and an effector molecule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023526059A JP2023526059A (ja) | 2023-06-20 |
| JP2023526059A5 true JP2023526059A5 (https=) | 2024-05-24 |
Family
ID=76284222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022568830A Pending JP2023526059A (ja) | 2020-05-14 | 2021-05-14 | ｍＲＮＡ治療薬及びエフェクター分子を含むＬＮＰ組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20230173104A1 (https=) |
| EP (1) | EP4149435A1 (https=) |
| JP (1) | JP2023526059A (https=) |
| AU (1) | AU2021270587A1 (https=) |
| CA (1) | CA3182920A1 (https=) |
| WO (1) | WO2021231854A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024026254A1 (en) * | 2022-07-26 | 2024-02-01 | Modernatx, Inc. | Engineered polynucleotides for temporal control of expression |
| CN115869332A (zh) * | 2022-10-27 | 2023-03-31 | 北京新合睿恩生物医疗科技有限公司 | 递送至体内后在肝脏少表达的mRNA药物及其制备方法 |
| WO2024137953A2 (en) * | 2022-12-22 | 2024-06-27 | Modernatx, Inc. | Small nuclear ribonucleoprotein 13 polypeptides, polynucleotides, and uses thereof |
| AU2024279278A1 (en) | 2023-05-31 | 2025-12-18 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| KR20250083381A (ko) * | 2023-11-30 | 2025-06-10 | 주식회사 레나임 | 골관절염의 예방 또는 치료용 약제학적 조성물 |
| WO2025255510A1 (en) * | 2024-06-07 | 2025-12-11 | The University Of Chicago | Systems and methods for modulating rna |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8613481D0 (en) | 1986-06-04 | 1986-07-09 | Diatech Ltd | Translation of mrna |
| GB2284210B (en) | 1993-11-26 | 1997-11-12 | British Tech Group | Translational enhancer DNA from a kinesin gene |
| US5824497A (en) | 1995-02-10 | 1998-10-20 | Mcmaster University | High efficiency translation of mRNA molecules |
| EP2447370B1 (en) | 2001-09-28 | 2018-07-18 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | MicroRNA molecules |
| US20050222064A1 (en) | 2002-02-20 | 2005-10-06 | Sirna Therapeutics, Inc. | Polycationic compositions for cellular delivery of polynucleotides |
| US7683036B2 (en) | 2003-07-31 | 2010-03-23 | Regulus Therapeutics Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding RNAs |
| DE102005046490A1 (de) | 2005-09-28 | 2007-03-29 | Johannes-Gutenberg-Universität Mainz | Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen |
| CA2715078C (en) | 2007-09-26 | 2019-07-23 | Intrexon Corporation | Synthetic 5'utrs, expression vectors, and methods for increasing transgene expression |
| EP2288336B8 (en) | 2008-04-25 | 2017-03-22 | Northwestern University | Nanostructures suitable for sequestering cholesterol |
| US9217155B2 (en) * | 2008-05-28 | 2015-12-22 | University Of Massachusetts | Isolation of novel AAV'S and uses thereof |
| PL215513B1 (pl) | 2008-06-06 | 2013-12-31 | Univ Warszawski | Nowe boranofosforanowe analogi dinukleotydów, ich zastosowanie, czasteczka RNA, sposób otrzymywania RNA oraz sposób otrzymywania peptydów lub bialka |
| KR101766408B1 (ko) | 2009-06-10 | 2017-08-10 | 알닐람 파마슈티칼스 인코포레이티드 | 향상된 지질 조성물 |
| CA2824526C (en) | 2011-01-11 | 2020-07-07 | Alnylam Pharmaceuticals, Inc. | Pegylated lipids and their use for drug delivery |
| WO2013013013A2 (en) * | 2011-07-21 | 2013-01-24 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for producing modified glycoproteins |
| US9163706B2 (en) | 2012-08-29 | 2015-10-20 | Greg SEBLANTE, SR. | Sprocket box for increasing the gas mileage of a vehicle with an automatic transmission |
| AU2013374345A1 (en) | 2013-01-17 | 2015-08-06 | Moderna Therapeutics, Inc. | Signal-sensor polynucleotides for the alteration of cellular phenotypes |
| US20160022840A1 (en) | 2013-03-09 | 2016-01-28 | Moderna Therapeutics, Inc. | Heterologous untranslated regions for mrna |
| US10821175B2 (en) | 2014-02-25 | 2020-11-03 | Merck Sharp & Dohme Corp. | Lipid nanoparticle vaccine adjuvants and antigen delivery systems |
| US20160052352A1 (en) | 2014-08-21 | 2016-02-25 | The Goodyear Tire & Rubber Company | Method of adhesion of rigid components to a tire |
| US9259829B1 (en) | 2014-08-25 | 2016-02-16 | Cougar Holdings, Llc | Roofing and nail removal hammer |
| JP7194594B2 (ja) * | 2016-05-18 | 2022-12-22 | モデルナティエックス インコーポレイテッド | 免疫調節ポリペプチドをコードするｍＲＮＡの組み合わせ及びその使用 |
| GB2568255A (en) * | 2017-11-08 | 2019-05-15 | Evox Therapeutics Ltd | Exosomes comprising RNA therapeutics |
| JP7556848B2 (ja) * | 2018-09-14 | 2024-09-26 | モデルナティエックス インコーポレイテッド | ｍＲＮＡ治療薬を使用したがんを治療するための方法及び組成物 |
-
2021
- 2021-05-14 WO PCT/US2021/032438 patent/WO2021231854A1/en not_active Ceased
- 2021-05-14 EP EP21730410.4A patent/EP4149435A1/en active Pending
- 2021-05-14 CA CA3182920A patent/CA3182920A1/en active Pending
- 2021-05-14 AU AU2021270587A patent/AU2021270587A1/en not_active Abandoned
- 2021-05-14 US US17/924,456 patent/US20230173104A1/en active Pending
- 2021-05-14 JP JP2022568830A patent/JP2023526059A/ja active Pending
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