JP2023523501A - Ｋｖ３モジュレーター - Google Patents

Ｋｖ３モジュレーター Download PDF

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Publication number
JP2023523501A
JP2023523501A JP2022547757A JP2022547757A JP2023523501A JP 2023523501 A JP2023523501 A JP 2023523501A JP 2022547757 A JP2022547757 A JP 2022547757A JP 2022547757 A JP2022547757 A JP 2022547757A JP 2023523501 A JP2023523501 A JP 2023523501A
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JP
Japan
Prior art keywords
disorders
compound
benzofuran
dione
imidazolidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022547757A
Other languages
English (en)
Japanese (ja)
Inventor
アルバロ ジュセッペ
マラスコ アゴスティーノ
Original Assignee
アウトイフオンイ トヘラペウトイクス リミテッド
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Filing date
Publication date
Application filed by アウトイフオンイ トヘラペウトイクス リミテッド filed Critical アウトイフオンイ トヘラペウトイクス リミテッド
Publication of JP2023523501A publication Critical patent/JP2023523501A/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
JP2022547757A 2020-02-06 2020-02-06 Ｋｖ３モジュレーター Pending JP2023523501A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/GB2020/050268 WO2021156584A1 (fr) 2020-02-06 2020-02-06 Modulateurs de kv3

Publications (1)

Publication Number Publication Date
JP2023523501A true JP2023523501A (ja) 2023-06-06

Family

ID=69591671

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022547757A Pending JP2023523501A (ja) 2020-02-06 2020-02-06 Ｋｖ３モジュレーター

Country Status (11)

Country Link
EP (1) EP4100402A1 (fr)
JP (1) JP2023523501A (fr)
KR (1) KR20220139923A (fr)
CN (1) CN115066424A (fr)
AU (1) AU2020427632A1 (fr)
BR (1) BR112022013339A2 (fr)
CA (1) CA3169057A1 (fr)
CL (1) CL2022002081A1 (fr)
IL (1) IL295027A (fr)
MX (1) MX2022009702A (fr)
WO (1) WO2021156584A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117448440A (zh) * 2023-10-23 2024-01-26 中国人民解放军空军军医大学 Kv3在制备诊断或治疗创伤后应激障碍异常恐惧记忆消退产品中的应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA019970B8 (ru) 2009-12-11 2014-11-28 Отифони Терапеутикс Лимитед Производные имидазолидиндиона
BR112013013914B1 (pt) 2010-12-06 2021-10-26 Autifony Therapeutics Limited Compostos derivados de hidantoína úteis como inibidores de kv3, usos dos referidos compostos e composição farmacêutica compreendendo os mesmos
WO2012168710A1 (fr) 2011-06-07 2012-12-13 Autifony Therapeutics Limited Dérivés d'hydantoïne en tant qu'inhibiteurs de kv3
GB201209986D0 (en) 2012-06-06 2012-07-18 Autifony Therapeutics Ltd Novel compounds
KR20140098850A (ko) * 2011-12-06 2014-08-08 오티포니 세라피틱스 리미티드 Kv3 억제제로서 유용한 하이단토인 유도체
BR112014028718A2 (pt) 2012-05-22 2017-06-27 Autifony Therapeutics Ltd derivados de hidantoína como inibidores de kv3
EP2852589B1 (fr) 2012-05-22 2021-04-28 Autifony Therapeutics Limited Triazoles en tant qu'inhibiteurs de kv3
WO2013182851A1 (fr) 2012-06-06 2013-12-12 Autifony Therapeutics Limited Prophylaxie ou traitement de maladies dans lesquelles un modulateur des canaux kv3.3 est requis
GB201521751D0 (en) 2015-12-10 2016-01-27 Autifony Therapeutics Ltd Novel uses
GB201522179D0 (en) 2015-12-16 2016-01-27 Autifony Therapeutics Ltd Novel compounds
GB201613163D0 (en) 2016-07-29 2016-09-14 Autifony Therapeutics Ltd Novel compounds
US20200039970A1 (en) 2016-12-16 2020-02-06 Autifony Therapeutics Limited Hydantoin modulators of kv3 channels
EP3853216A4 (fr) 2018-09-21 2022-08-10 Bionomics Limited Composés substitués par pyridinyle et leurs utilisations
BR112021006940A2 (pt) * 2018-10-16 2021-07-13 Autifony Therapeutics Limited compostos
US20220112176A1 (en) 2019-03-25 2022-04-14 Bionomics Limited Substituted-n-heteroaryl compounds and uses thereof

Also Published As

Publication number Publication date
KR20220139923A (ko) 2022-10-17
AU2020427632A1 (en) 2022-08-18
WO2021156584A1 (fr) 2021-08-12
MX2022009702A (es) 2022-09-07
CA3169057A1 (fr) 2021-08-12
CL2022002081A1 (es) 2023-05-26
CN115066424A (zh) 2022-09-16
EP4100402A1 (fr) 2022-12-14
IL295027A (en) 2022-09-01
BR112022013339A2 (pt) 2022-09-13

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