CL2022002081A1 - Moduladores de kv3 - Google Patents

Moduladores de kv3

Info

Publication number
CL2022002081A1
CL2022002081A1 CL2022002081A CL2022002081A CL2022002081A1 CL 2022002081 A1 CL2022002081 A1 CL 2022002081A1 CL 2022002081 A CL2022002081 A CL 2022002081A CL 2022002081 A CL2022002081 A CL 2022002081A CL 2022002081 A1 CL2022002081 A1 CL 2022002081A1
Authority
CL
Chile
Prior art keywords
modulators
compound
formula
related aspects
aspects
Prior art date
Application number
CL2022002081A
Other languages
English (en)
Inventor
Alvaro Giuseppe
Marasco Agostino
Original Assignee
Autifony Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Autifony Therapeutics Ltd filed Critical Autifony Therapeutics Ltd
Publication of CL2022002081A1 publication Critical patent/CL2022002081A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Un compuesto de fórmula (I); y aspectos relacionados.
CL2022002081A 2020-02-06 2022-08-02 Moduladores de kv3 CL2022002081A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/GB2020/050268 WO2021156584A1 (en) 2020-02-06 2020-02-06 Kv3 modulators

Publications (1)

Publication Number Publication Date
CL2022002081A1 true CL2022002081A1 (es) 2023-05-26

Family

ID=69591671

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2022002081A CL2022002081A1 (es) 2020-02-06 2022-08-02 Moduladores de kv3

Country Status (11)

Country Link
EP (1) EP4100402A1 (es)
JP (1) JP2023523501A (es)
KR (1) KR20220139923A (es)
CN (1) CN115066424A (es)
AU (1) AU2020427632A1 (es)
BR (1) BR112022013339A2 (es)
CA (1) CA3169057A1 (es)
CL (1) CL2022002081A1 (es)
IL (1) IL295027A (es)
MX (1) MX2022009702A (es)
WO (1) WO2021156584A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117448440A (zh) * 2023-10-23 2024-01-26 中国人民解放军空军军医大学 Kv3在制备诊断或治疗创伤后应激障碍异常恐惧记忆消退产品中的应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA019970B8 (ru) 2009-12-11 2014-11-28 Отифони Терапеутикс Лимитед Производные имидазолидиндиона
BR112013013914B1 (pt) 2010-12-06 2021-10-26 Autifony Therapeutics Limited Compostos derivados de hidantoína úteis como inibidores de kv3, usos dos referidos compostos e composição farmacêutica compreendendo os mesmos
WO2012168710A1 (en) 2011-06-07 2012-12-13 Autifony Therapeutics Limited Hydantoin derivates as kv3 inhibitors
GB201209986D0 (en) 2012-06-06 2012-07-18 Autifony Therapeutics Ltd Novel compounds
KR20140098850A (ko) * 2011-12-06 2014-08-08 오티포니 세라피틱스 리미티드 Kv3 억제제로서 유용한 하이단토인 유도체
BR112014028718A2 (pt) 2012-05-22 2017-06-27 Autifony Therapeutics Ltd derivados de hidantoína como inibidores de kv3
EP2852589B1 (en) 2012-05-22 2021-04-28 Autifony Therapeutics Limited Triazoles as kv3 inhibitors
WO2013182851A1 (en) 2012-06-06 2013-12-12 Autifony Therapeutics Limited Prophylaxis or treatment of diseases where a modulator of kv3.3 channels is required
GB201521751D0 (en) 2015-12-10 2016-01-27 Autifony Therapeutics Ltd Novel uses
GB201522179D0 (en) 2015-12-16 2016-01-27 Autifony Therapeutics Ltd Novel compounds
GB201613163D0 (en) 2016-07-29 2016-09-14 Autifony Therapeutics Ltd Novel compounds
US20200039970A1 (en) 2016-12-16 2020-02-06 Autifony Therapeutics Limited Hydantoin modulators of kv3 channels
EP3853216A4 (en) 2018-09-21 2022-08-10 Bionomics Limited PYRIDINYL SUBSTITUTE COMPOUNDS AND THEIR USES
BR112021006940A2 (pt) * 2018-10-16 2021-07-13 Autifony Therapeutics Limited compostos
US20220112176A1 (en) 2019-03-25 2022-04-14 Bionomics Limited Substituted-n-heteroaryl compounds and uses thereof

Also Published As

Publication number Publication date
KR20220139923A (ko) 2022-10-17
AU2020427632A1 (en) 2022-08-18
WO2021156584A1 (en) 2021-08-12
MX2022009702A (es) 2022-09-07
CA3169057A1 (en) 2021-08-12
CN115066424A (zh) 2022-09-16
EP4100402A1 (en) 2022-12-14
IL295027A (en) 2022-09-01
BR112022013339A2 (pt) 2022-09-13
JP2023523501A (ja) 2023-06-06

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