JP2023520714A - Ｔｓｌｐに特異的な二環式ペプチドリガンド - Google Patents

Ｔｓｌｐに特異的な二環式ペプチドリガンド Download PDF

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Publication number
JP2023520714A
JP2023520714A JP2022560943A JP2022560943A JP2023520714A JP 2023520714 A JP2023520714 A JP 2023520714A JP 2022560943 A JP2022560943 A JP 2022560943A JP 2022560943 A JP2022560943 A JP 2022560943A JP 2023520714 A JP2023520714 A JP 2023520714A
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JP
Japan
Prior art keywords
seq
hereinafter referred
amino acids
peptide
peptide ligand
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Pending
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JP2022560943A
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English (en)
Japanese (ja)
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JP2023520714A5 (https=
JPWO2021205161A5 (https=
Inventor
ナージェス フランク
スベンソン トール
ズラトイドスキー パボル
ハイデスタル ロッタ
チェン リューホン
スカイナー マイケル
ワッチャム ソフィー
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BicycleTx Ltd
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BicycleTx Ltd
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Filing date
Publication date
Application filed by BicycleTx Ltd filed Critical BicycleTx Ltd
Publication of JP2023520714A publication Critical patent/JP2023520714A/ja
Publication of JP2023520714A5 publication Critical patent/JP2023520714A5/ja
Publication of JPWO2021205161A5 publication Critical patent/JPWO2021205161A5/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2022560943A 2020-04-06 2021-04-06 Ｔｓｌｐに特異的な二環式ペプチドリガンド Pending JP2023520714A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063005744P 2020-04-06 2020-04-06
US63/005,744 2020-04-06
PCT/GB2021/050846 WO2021205161A1 (en) 2020-04-06 2021-04-06 Bicyclic peptide ligands specific for tslp

Publications (3)

Publication Number Publication Date
JP2023520714A true JP2023520714A (ja) 2023-05-18
JP2023520714A5 JP2023520714A5 (https=) 2024-04-11
JPWO2021205161A5 JPWO2021205161A5 (https=) 2024-04-11

Family

ID=75539693

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022560943A Pending JP2023520714A (ja) 2020-04-06 2021-04-06 Ｔｓｌｐに特異的な二環式ペプチドリガンド

Country Status (5)

Country Link
US (1) US11866518B2 (https=)
EP (1) EP4132481A1 (https=)
JP (1) JP2023520714A (https=)
CN (1) CN115768456A (https=)
WO (1) WO2021205161A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201918557D0 (en) * 2019-12-16 2020-01-29 Bicycle Tx Ltd Bicyclic peptide ligands specific for IL-17
CN115768456A (zh) 2020-04-06 2023-03-07 拜斯科技术开发有限公司 Tslp特异性的双环肽配体

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008529482A (ja) * 2005-01-24 2008-08-07 ペプスキャン システムズ ベー．フェー． 結合化合物、免疫原性化合物およびペプチド模倣体
JP2011514803A (ja) * 2008-02-05 2011-05-12 メディカル リサーチ カウンシル 方法及び組成物
JP2016519683A (ja) * 2013-04-11 2016-07-07 バイサイクル・セラピューティクス・リミテッド 構築されたポリペプチド特異性のモジュレーション
US20170066823A1 (en) * 2015-09-09 2017-03-09 Matthew John EDWARDS Thymic stromal lymphopoietin (tslp)-binding molecules and methods of using the molecules

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001271624A1 (en) * 2000-06-28 2002-01-08 Whitehead Institute For Biomedical Research Thymic stromal lymphopoietin receptor molecules and uses thereof
EP1452868A2 (en) 2003-02-27 2004-09-01 Pepscan Systems B.V. Method for selecting a candidate drug compound
KR101843248B1 (ko) * 2015-03-17 2018-03-29 고려대학교 세종산학협력단 흉선 기질 림프단백질 매개 신호전달을 제어하는 펩타이드 유도체 및 이를 포함하는 알러지 및 천식 질환 예방 및 치료용 약학 조성물
AR111380A1 (es) * 2017-04-12 2019-07-03 Amgen Inc Tratamiento para el asma con anticuerpo anti-tslp
CN115768456A (zh) 2020-04-06 2023-03-07 拜斯科技术开发有限公司 Tslp特异性的双环肽配体

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008529482A (ja) * 2005-01-24 2008-08-07 ペプスキャン システムズ ベー．フェー． 結合化合物、免疫原性化合物およびペプチド模倣体
JP2011514803A (ja) * 2008-02-05 2011-05-12 メディカル リサーチ カウンシル 方法及び組成物
JP2016519683A (ja) * 2013-04-11 2016-07-07 バイサイクル・セラピューティクス・リミテッド 構築されたポリペプチド特異性のモジュレーション
US20170066823A1 (en) * 2015-09-09 2017-03-09 Matthew John EDWARDS Thymic stromal lymphopoietin (tslp)-binding molecules and methods of using the molecules

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ACC. CHEM. RES., vol. 50, JPN6025014863, 2017, pages 1866 - 1874, ISSN: 0005572210 *

Also Published As

Publication number Publication date
WO2021205161A1 (en) 2021-10-14
CN115768456A (zh) 2023-03-07
US11866518B2 (en) 2024-01-09
EP4132481A1 (en) 2023-02-15
US20220363718A1 (en) 2022-11-17

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