CN115768456A - Tslp特异性的双环肽配体 - Google Patents

Tslp特异性的双环肽配体 Download PDF

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Publication number
CN115768456A
CN115768456A CN202180038689.5A CN202180038689A CN115768456A CN 115768456 A CN115768456 A CN 115768456A CN 202180038689 A CN202180038689 A CN 202180038689A CN 115768456 A CN115768456 A CN 115768456A
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CN
China
Prior art keywords
seq
hereinafter referred
xaa
fphe
cys
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180038689.5A
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English (en)
Chinese (zh)
Inventor
F·纳雷什
T·斯文森
P·兹拉托德斯基
L·海德斯特
L·陈
M·斯基内
S·沃茶木
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BicycleTx Ltd
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BicycleTx Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BicycleTx Ltd filed Critical BicycleTx Ltd
Publication of CN115768456A publication Critical patent/CN115768456A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202180038689.5A 2020-04-06 2021-04-06 Tslp特异性的双环肽配体 Pending CN115768456A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063005744P 2020-04-06 2020-04-06
US63/005,744 2020-04-06
PCT/GB2021/050846 WO2021205161A1 (en) 2020-04-06 2021-04-06 Bicyclic peptide ligands specific for tslp

Publications (1)

Publication Number Publication Date
CN115768456A true CN115768456A (zh) 2023-03-07

Family

ID=75539693

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180038689.5A Pending CN115768456A (zh) 2020-04-06 2021-04-06 Tslp特异性的双环肽配体

Country Status (5)

Country Link
US (1) US11866518B2 (https=)
EP (1) EP4132481A1 (https=)
JP (1) JP2023520714A (https=)
CN (1) CN115768456A (https=)
WO (1) WO2021205161A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201918557D0 (en) * 2019-12-16 2020-01-29 Bicycle Tx Ltd Bicyclic peptide ligands specific for IL-17
CN115768456A (zh) 2020-04-06 2023-03-07 拜斯科技术开发有限公司 Tslp特异性的双环肽配体

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020160949A1 (en) * 2000-06-28 2002-10-31 Whitehead Institute For Biomedical Thymic stromal lymphopoietin receptor molecules and uses thereof
WO2014167122A1 (en) * 2013-04-11 2014-10-16 Bicycle Therapeutics Limited Modulation of structured polypeptide specificity
KR20160111846A (ko) * 2015-03-17 2016-09-27 고려대학교 산학협력단 흉선 기질 림프단백질 매개 신호전달을 제어하는 펩타이드 유도체 및 이를 포함하는 알러지 및 천식 질환 예방 및 치료용 약학 조성물
US20170066823A1 (en) * 2015-09-09 2017-03-09 Matthew John EDWARDS Thymic stromal lymphopoietin (tslp)-binding molecules and methods of using the molecules
AR111380A1 (es) * 2017-04-12 2019-07-03 Amgen Inc Tratamiento para el asma con anticuerpo anti-tslp

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1452868A2 (en) 2003-02-27 2004-09-01 Pepscan Systems B.V. Method for selecting a candidate drug compound
DK1844337T3 (da) * 2005-01-24 2013-09-30 Pepscan Systems Bv Bindingsforbindelser, immunogene forbindelser og peptidmimetika
AU2009211253B2 (en) * 2008-02-05 2014-11-06 Bicyclerd Limited Methods and compositions
CN115768456A (zh) 2020-04-06 2023-03-07 拜斯科技术开发有限公司 Tslp特异性的双环肽配体

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020160949A1 (en) * 2000-06-28 2002-10-31 Whitehead Institute For Biomedical Thymic stromal lymphopoietin receptor molecules and uses thereof
WO2014167122A1 (en) * 2013-04-11 2014-10-16 Bicycle Therapeutics Limited Modulation of structured polypeptide specificity
KR20160111846A (ko) * 2015-03-17 2016-09-27 고려대학교 산학협력단 흉선 기질 림프단백질 매개 신호전달을 제어하는 펩타이드 유도체 및 이를 포함하는 알러지 및 천식 질환 예방 및 치료용 약학 조성물
US20170066823A1 (en) * 2015-09-09 2017-03-09 Matthew John EDWARDS Thymic stromal lymphopoietin (tslp)-binding molecules and methods of using the molecules
AR111380A1 (es) * 2017-04-12 2019-07-03 Amgen Inc Tratamiento para el asma con anticuerpo anti-tslp

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CALIENDO G, SANTAGADA V, PERISSUTTI E, ET AL.: "Kallikrein protease activated receptor (PAR) axis: an attractive target for drug development", JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, 18 May 2012 (2012-05-18) *
何蓉;李清福;夏缨;李晓艳;何彦蓉;张维;李露;: "沙格列汀抑制NF-κB信号通路下调LPS诱导的人肾小管上皮HK-2细胞MCP-1的表达", 西部医学, no. 10, 20 October 2015 (2015-10-20) *
王文婕;王晓川;章迁;陈莲;王莹;徐振;: "小鼠哮喘模型胸腺中胸腺基质淋巴生成素、Foxp3的表达及调节", 中国循证儿科杂志, no. 04, 10 July 2008 (2008-07-10) *

Also Published As

Publication number Publication date
JP2023520714A (ja) 2023-05-18
WO2021205161A1 (en) 2021-10-14
US11866518B2 (en) 2024-01-09
EP4132481A1 (en) 2023-02-15
US20220363718A1 (en) 2022-11-17

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Application publication date: 20230307