JP2023519807A - 癌治療方法 - Google Patents

癌治療方法 Download PDF

Info

Publication number
JP2023519807A
JP2023519807A JP2022550848A JP2022550848A JP2023519807A JP 2023519807 A JP2023519807 A JP 2023519807A JP 2022550848 A JP2022550848 A JP 2022550848A JP 2022550848 A JP2022550848 A JP 2022550848A JP 2023519807 A JP2023519807 A JP 2023519807A
Authority
JP
Japan
Prior art keywords
seq
amino acid
acid sequence
cancer
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022550848A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023519807A5 (https=
Inventor
エリン アッカーマン、シェリー
エヌ． アロンソ、マイケル
ドーナン、デイヴィッド
エル． コワネツ、マルシン
エス． シコルスキ、ロバート
エー． スミス、スティーヴン
Original Assignee
ボルト バイオセラピューティクス、インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ボルト バイオセラピューティクス、インコーポレーテッド filed Critical ボルト バイオセラピューティクス、インコーポレーテッド
Publication of JP2023519807A publication Critical patent/JP2023519807A/ja
Publication of JP2023519807A5 publication Critical patent/JP2023519807A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2022550848A 2020-02-25 2021-02-25 癌治療方法 Pending JP2023519807A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202062981355P 2020-02-25 2020-02-25
US62/981,355 2020-02-25
US202063105104P 2020-10-23 2020-10-23
US63/105,104 2020-10-23
PCT/US2021/019667 WO2021173832A1 (en) 2020-02-25 2021-02-25 Cancer treatment methods

Publications (2)

Publication Number Publication Date
JP2023519807A true JP2023519807A (ja) 2023-05-15
JP2023519807A5 JP2023519807A5 (https=) 2024-02-26

Family

ID=75143716

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022550848A Pending JP2023519807A (ja) 2020-02-25 2021-02-25 癌治療方法

Country Status (7)

Country Link
US (1) US20230165968A1 (https=)
EP (1) EP4110403A1 (https=)
JP (1) JP2023519807A (https=)
KR (1) KR20220145871A (https=)
AU (1) AU2021226570A1 (https=)
CA (1) CA3169117A1 (https=)
WO (1) WO2021173832A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109843327B (zh) 2016-07-07 2022-05-13 小利兰·斯坦福大学托管委员会 抗体佐剂缀合物
WO2020190725A1 (en) 2019-03-15 2020-09-24 Bolt Biotherapeutics, Inc. Immunoconjugates targeting her2
WO2024130003A1 (en) 2022-12-15 2024-06-20 Bolt Biotherapeutics, Inc. Cancer combination treatment method
CA3221817A1 (en) * 2023-06-30 2025-06-13 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Combination therapies for the treatment of cancer

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009510096A (ja) * 2005-09-27 2009-03-12 コーリー ファーマシューティカル ゲーエムベーハー アダプターオリゴヌクレオチドを用いたｔｌｒ媒介免疫応答の調節
WO2018160538A1 (en) * 2017-02-28 2018-09-07 Mersana Therapeutics, Inc. Combination therapies of her2-targeted antibody-drug conjugates
JP2019518426A (ja) * 2016-04-15 2019-07-04 ジェネンテック， インコーポレイテッド がんの診断及び治療方法
JP2019520352A (ja) * 2016-07-07 2019-07-18 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 抗体アジュバント複合体
WO2019222676A1 (en) * 2018-05-17 2019-11-21 Bolt Biotherapeutics, Inc. Immunoconjugates

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3101690B2 (ja) 1987-03-18 2000-10-23 エス・ビィ・２・インコーポレイテッド 変性抗体の、または変性抗体に関する改良
JP2003531149A (ja) 2000-04-13 2003-10-21 ザ・ロツクフエラー・ユニバーシテイ 抗体由来の免疫応答の増強
WO2006073921A2 (en) 2004-12-30 2006-07-13 The Rockefeller University Compositions and methods for enhanced dendritic cell maturation and function
US20080286819A1 (en) 2005-11-07 2008-11-20 Ravetch Jeffrey V Reagents, Methods and Systems for Selecting a Cytotoxic Antibody or Variant Thereof
AU2015349878A1 (en) 2014-11-21 2017-05-25 Bristol-Myers Squibb Company Antibodies against CD73 and uses thereof
WO2017087280A1 (en) * 2015-11-16 2017-05-26 Genentech, Inc. Methods of treating her2-positive cancer
US20220152215A1 (en) * 2019-03-15 2022-05-19 Bolt Biotherapeutics, Inc. Immunoconjugates Targeting CEA
US20220143012A1 (en) * 2019-03-15 2022-05-12 Bolt Biotherapeutics, Inc. Macromolecule-Supported TLR Agonists
WO2020190725A1 (en) * 2019-03-15 2020-09-24 Bolt Biotherapeutics, Inc. Immunoconjugates targeting her2
US20220226491A1 (en) * 2019-03-15 2022-07-21 Bolt Biotherapeutics, Inc. Immunoconjugates Targeting PD-L1
WO2020190731A1 (en) * 2019-03-15 2020-09-24 Bolt Biotherapeutics, Inc. Immunoconjugates targeting her2

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009510096A (ja) * 2005-09-27 2009-03-12 コーリー ファーマシューティカル ゲーエムベーハー アダプターオリゴヌクレオチドを用いたｔｌｒ媒介免疫応答の調節
JP2019518426A (ja) * 2016-04-15 2019-07-04 ジェネンテック， インコーポレイテッド がんの診断及び治療方法
JP2019520352A (ja) * 2016-07-07 2019-07-18 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 抗体アジュバント複合体
WO2018160538A1 (en) * 2017-02-28 2018-09-07 Mersana Therapeutics, Inc. Combination therapies of her2-targeted antibody-drug conjugates
WO2019222676A1 (en) * 2018-05-17 2019-11-21 Bolt Biotherapeutics, Inc. Immunoconjugates

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
WHO DRUG INFORMATION, vol. 32, no. 2, JPN6024046562, 2018, pages 283 - 307, ISSN: 0005603493 *
WHO DRUG INFORMATION, vol. 34, no. 2, JPN6024046561, 2020, pages 263 - 420, ISSN: 0005603494 *
イミフィンジ点滴静注５００ＭＧの添付文書、デュルバルマブ（遺伝子組換え製剤）, vol. 2018年販売開始、retrieved on 2024.11.12, JPN6024046563, pages retrieved from the internet, ISSN: 0005603492 *
エンハーツ点滴静注用１００ＭＧの添付文書、トラスツズマブ デルクステカン（遺伝子組換え）, vol. 2020年販売開始、retrieved on 2024.11.12, JPN6024046566, pages retrieved from the internet, ISSN: 0005603489 *
オプチーボ点滴静注２４０ＭＧの添付文書、ニボルマブ（遺伝子組換え製剤）, vol. 2018年販売開始、retrieved on 2024.11.12, JPN6024046565, pages retrieved from the internet, ISSN: 0005603490 *
カドサイラ点滴静注用１００ＭＧ、同点滴静注用１６０ＭＧの添付文書、トラスツズマブ エムタンシン（遺伝, vol. 2014年販売開始、retrieved on 2024.11.12, JPN6024046567, pages retrieved from the internet, ISSN: 0005603488 *
キイトルーダ点滴静注１００ＭＧの添付文書、ペムブロリズマブ（遺伝子組換え製剤）, vol. 2017年販売開始、retrieved on 2024.11.12, JPN6024046564, pages retrieved from the internet, ISSN: 0005603491 *

Also Published As

Publication number Publication date
US20230165968A1 (en) 2023-06-01
CA3169117A1 (en) 2021-09-02
KR20220145871A (ko) 2022-10-31
AU2021226570A1 (en) 2022-09-29
EP4110403A1 (en) 2023-01-04
WO2021173832A1 (en) 2021-09-02

Similar Documents

Publication Publication Date Title
EP3515945B1 (en) Anti-steap2 antibodies, antibody-drug conjugates, and uses thereof
KR102584340B1 (ko) 활성화가능한 항-ctla-4 항체 및 그의 용도
JP7102670B2 (ja) 抗ｐｄ‐ｌ１抗体とｉｌ‐７との融合
JP2023519807A (ja) 癌治療方法
AU2017339711A1 (en) Bi specific anti-MUC16-CD3 antibodies and anti-MUC16 drug conjugates
JP2022525594A (ja) Ｈｅｒ２を標的とする免疫結合体
KR102608723B1 (ko) 항―ｐｄ－１ 항체 및 그의 용도
TWI884911B (zh) 具有改良之免疫療效但減弱之副作用之突變抗ctla-4抗體
JP7479281B2 (ja) 抗ｏｘ４０抗体及びその用途
JP7469305B2 (ja) 抗ｐｄ－１抗体およびその使用
US11680102B2 (en) Anti-BAFF receptor antibodies and uses thereof
AU2021232158A1 (en) Anti-CD36 antibodies and their use to treat cancer
CN115397859A (zh) 治疗癌症和癌症转移的联合疗法
WO2024026374A1 (en) Anti-cd16a antibodies and methods of use thereof
AU2022320051A1 (en) Anti-cd36 antibodies and their use to treat cancer
WO2023001118A1 (zh) 抗ox40抗体在联合用药中的应用
EP4359440A1 (en) Anti-egfrviii antibody drug conjugates and uses thereof
JP2024515879A (ja) 抗ｓｉｇｌｅｃ組成物及びその使用
KR20230050356A (ko) Pd-l1 및 tgf-베타를 표적화하는 이기능적 분자
WO2024130003A1 (en) Cancer combination treatment method
HK40098451A (zh) 抗ccr8单克隆抗体及其用途
EA040545B1 (ru) Анти-prlr антитела и их применение

Legal Events

Date Code Title Description
RD01 Notification of change of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7426

Effective date: 20230120

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20230120

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240214

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20240214

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20241119

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20241120

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20250527