JP2023519640A - 脱最適化されたＳＡＲＳ－ＣｏＶ－２ならびにその方法および使用 - Google Patents

脱最適化されたＳＡＲＳ－ＣｏＶ－２ならびにその方法および使用 Download PDF

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JP2023519640A
JP2023519640A JP2022572258A JP2022572258A JP2023519640A JP 2023519640 A JP2023519640 A JP 2023519640A JP 2022572258 A JP2022572258 A JP 2022572258A JP 2022572258 A JP2022572258 A JP 2022572258A JP 2023519640 A JP2023519640 A JP 2023519640A
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sars
coronavirus
polynucleotide
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JPWO2021154828A5 (https=
JP2023519640A5 (https=
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シュテフェン ミュラー
ジョン ロバート コールマン
イン ワン
チェン ヤン
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Codagenix Inc
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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JP2022572258A 2020-01-28 2021-01-27 脱最適化されたＳＡＲＳ－ＣｏＶ－２ならびにその方法および使用 Pending JP2023519640A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US202062966750P 2020-01-28 2020-01-28
US62/966,750 2020-01-28
US202063048942P 2020-07-07 2020-07-07
US63/048,942 2020-07-07
US202063079337P 2020-09-16 2020-09-16
US63/079,337 2020-09-16
US202063079853P 2020-09-17 2020-09-17
US63/079,853 2020-09-17
PCT/US2021/015246 WO2021154828A1 (en) 2020-01-28 2021-01-27 DEOPTIMIZED SARS-CoV-2 AND METHODS AND USES THEREOF

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JP2023519640A true JP2023519640A (ja) 2023-05-11
JPWO2021154828A5 JPWO2021154828A5 (https=) 2024-02-06
JP2023519640A5 JP2023519640A5 (https=) 2024-02-06

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US (1) US20230117167A1 (https=)
EP (1) EP4096712A4 (https=)
JP (1) JP2023519640A (https=)
KR (1) KR20220132588A (https=)
CN (1) CN115427073A (https=)
AU (1) AU2021213121A1 (https=)
BR (1) BR112022014700A2 (https=)
CA (1) CA3168100A1 (https=)
CL (1) CL2022002030A1 (https=)
CO (1) CO2022010743A2 (https=)
IL (1) IL295112A (https=)
MX (1) MX2022009099A (https=)
PE (1) PE20230166A1 (https=)
PH (1) PH12022551788A1 (https=)
SA (1) SA522433428B1 (https=)
TW (1) TW202144570A (https=)
WO (1) WO2021154828A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12194089B2 (en) 2020-02-04 2025-01-14 CureVac SE Coronavirus vaccine
US11241493B2 (en) 2020-02-04 2022-02-08 Curevac Ag Coronavirus vaccine
CN115297892A (zh) * 2020-02-07 2022-11-04 达冕生物有限公司 抗新型冠状病毒感染的mRNA疫苗的组合物和方法
WO2021177773A2 (ko) * 2020-03-06 2021-09-10 (주)지노믹트리 Sars-cov-2 진단용 조성물, 키트 및 이를 이용한 sars-cov-2의 진단방법
US12558415B2 (en) * 2020-04-14 2026-02-24 The Regents Of The University Of California Broad-spectrum multi-antigen pan-coronavirus vaccine
WO2022011428A1 (en) * 2020-07-16 2022-01-20 Griffith University Live-attenuated virus vaccine
US20240156946A1 (en) 2020-12-22 2024-05-16 CureVac SE Rna vaccine against sars-cov-2 variants
WO2023018831A2 (en) 2021-08-11 2023-02-16 RNAimmune, Inc. Composition and methods of mrna vaccines against novel coronavirus infection
WO2023037387A2 (en) 2021-09-08 2023-03-16 Serum Institute Of India Private Limited Freeze-dried viral combination vaccine compositions and process for preparation thereof
AU2022435931A1 (en) * 2022-01-20 2024-07-18 Freie Universität Berlin A live attenuated sars-cov-2 and a vaccine made thereof
WO2023186946A1 (en) * 2022-03-28 2023-10-05 Universität Bern One-to-stop attenuated sars-cov-2 virus
EP4331602A1 (en) * 2022-09-05 2024-03-06 Freie Universität Berlin A live attenuated sars-cov-2 and a vaccine made thereof
CA3266020A1 (en) 2022-09-05 2024-03-14 Freie Universitat Berlin LIVE ATTENUATED SARS-CoV-2 AND VACCINE MADE FROM IT
KR20250084962A (ko) * 2022-10-12 2025-06-11 유니버시태트 베른 원-투-스톱 약독화된 SARS-CoV-2 바이러스를 사용한 치료
WO2024089638A1 (en) 2022-10-28 2024-05-02 Glaxosmithkline Biologicals Sa Nucleic acid based vaccine
US12280104B2 (en) 2022-11-01 2025-04-22 RNAimmune, Inc. Composition and methods for MRNA vaccines against novel omicron coronavirus infections
WO2025081050A1 (en) * 2023-10-13 2025-04-17 Duke University Coronavirus stem helix and fusion peptide nanoparticle vaccines

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080118530A1 (en) * 2004-10-08 2008-05-22 Kew Olen M Modulation of Replicative Fitness By Deoptimization of Synonymous Codons
JP2010523086A (ja) * 2007-03-30 2010-07-15 ザ・リサーチ・ファウンデーション・オブ・ステート・ユニヴァーシティー・オブ・ニュー・ヨーク ワクチンに有用な弱毒化ウイルス
JP2018537103A (ja) * 2015-12-11 2018-12-20 ザ ユナイテッド ステイツ オブ アメリカ アズ リプリゼンテッド バイ ザ セクレタリー、デパートメント オブ ヘルス アンド ヒューマン サービシーズＴｈｅ Ｕ．Ｓ．Ａ．Ａｓ Ｒｅｐｒｅｓｅｎｔｅｄ Ｂｙ Ｔｈｅ Ｓｅｃｒｅｔａｒｙ，Ｄｅｐａｒｔｍｅｎｔ Ｏｆ Ｈｅａｌｔｈ Ａｎｄ Ｈｕｍａｎ Ｓｅｒｖｉｃｅｓ Ｎｓ１およびｎｓ２遺伝子シフトを含む組換えｒｓウイルス株
JP2021500880A (ja) * 2017-10-16 2021-01-14 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム ２つの発現カセットを有するサルアデノウイルスベクター

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7339051B2 (en) * 2003-04-28 2008-03-04 Isis Pharmaceuticals, Inc. Compositions and methods for the treatment of severe acute respiratory syndrome (SARS)
TW201125984A (en) * 2009-10-09 2011-08-01 Univ New York State Res Found Attenuated influenza viruses and vaccines
MX2019011599A (es) * 2017-03-30 2019-12-19 Univ Queensland Moleculas quimericas y usos de las mismas.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080118530A1 (en) * 2004-10-08 2008-05-22 Kew Olen M Modulation of Replicative Fitness By Deoptimization of Synonymous Codons
JP2010523086A (ja) * 2007-03-30 2010-07-15 ザ・リサーチ・ファウンデーション・オブ・ステート・ユニヴァーシティー・オブ・ニュー・ヨーク ワクチンに有用な弱毒化ウイルス
JP2018537103A (ja) * 2015-12-11 2018-12-20 ザ ユナイテッド ステイツ オブ アメリカ アズ リプリゼンテッド バイ ザ セクレタリー、デパートメント オブ ヘルス アンド ヒューマン サービシーズＴｈｅ Ｕ．Ｓ．Ａ．Ａｓ Ｒｅｐｒｅｓｅｎｔｅｄ Ｂｙ Ｔｈｅ Ｓｅｃｒｅｔａｒｙ，Ｄｅｐａｒｔｍｅｎｔ Ｏｆ Ｈｅａｌｔｈ Ａｎｄ Ｈｕｍａｎ Ｓｅｒｖｉｃｅｓ Ｎｓ１およびｎｓ２遺伝子シフトを含む組換えｒｓウイルス株
JP2021500880A (ja) * 2017-10-16 2021-01-14 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム ２つの発現カセットを有するサルアデノウイルスベクター

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"Betacoronavirus sp. isolate Wuhan-Hu-1, complete genome", DATABASE DDBJ/EMBL/GENBANK [ONLINE]，ACCESSION NO.MN908947.1, vol. [検索日 2024.12.17], JPN6024052211, 12 January 2020 (2020-01-12), ISSN: 0005607484 *

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AU2021213121A1 (en) 2022-08-18
KR20220132588A (ko) 2022-09-30
US20230117167A1 (en) 2023-04-20
SA522433428B1 (ar) 2024-10-08
CN115427073A (zh) 2022-12-02
PE20230166A1 (es) 2023-02-01
EP4096712A1 (en) 2022-12-07
WO2021154828A1 (en) 2021-08-05
EP4096712A4 (en) 2024-05-08
CA3168100A1 (en) 2021-08-05
IL295112A (en) 2022-09-01
PH12022551788A1 (en) 2024-02-26
CL2022002030A1 (es) 2023-03-10
BR112022014700A2 (pt) 2022-10-11
TW202144570A (zh) 2021-12-01
MX2022009099A (es) 2022-10-20
CO2022010743A2 (es) 2022-08-30

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