JP2023515567A - Ｐｂｐ３結合二環式ペプチドリガンド - Google Patents

Ｐｂｐ３結合二環式ペプチドリガンド Download PDF

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Publication number
JP2023515567A
JP2023515567A JP2022551274A JP2022551274A JP2023515567A JP 2023515567 A JP2023515567 A JP 2023515567A JP 2022551274 A JP2022551274 A JP 2022551274A JP 2022551274 A JP2022551274 A JP 2022551274A JP 2023515567 A JP2023515567 A JP 2023515567A
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JP
Japan
Prior art keywords
seq
referred
acid
peptide
pbp3
Prior art date
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Ceased
Application number
JP2022551274A
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English (en)
Japanese (ja)
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JP2023515567A5 (https=
Inventor
バームフォース マシュー
ベスウィック ポール
チェン リューホン
ドーソン マイク
ドッズ レイチェル
ローランド キャサリン
スカイナー マイケル
ヴァン リーツチョーテン カテリーヌ
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BicycleTx Ltd
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BicycleTx Ltd
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Publication date
Application filed by BicycleTx Ltd filed Critical BicycleTx Ltd
Publication of JP2023515567A publication Critical patent/JP2023515567A/ja
Publication of JP2023515567A5 publication Critical patent/JP2023515567A5/ja
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
JP2022551274A 2020-02-26 2021-02-26 Ｐｂｐ３結合二環式ペプチドリガンド Ceased JP2023515567A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB2002706.6A GB202002706D0 (en) 2020-02-26 2020-02-26 Pbp3 binding bicyclic peptide ligands
GB2002706.6 2020-02-26
PCT/GB2021/050491 WO2021171029A1 (en) 2020-02-26 2021-02-26 Pbp3 binding bicyclic peptide ligands

Publications (2)

Publication Number Publication Date
JP2023515567A true JP2023515567A (ja) 2023-04-13
JP2023515567A5 JP2023515567A5 (https=) 2024-03-01

Family

ID=70108251

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022551274A Ceased JP2023515567A (ja) 2020-02-26 2021-02-26 Ｐｂｐ３結合二環式ペプチドリガンド

Country Status (6)

Country Link
US (1) US20230106511A1 (https=)
EP (1) EP4110791A1 (https=)
JP (1) JP2023515567A (https=)
CN (1) CN115443285A (https=)
GB (1) GB202002706D0 (https=)
WO (1) WO2021171029A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107148425B (zh) 2014-10-29 2021-08-03 拜斯科阿迪有限公司 对mt1-mmp特异性的双环肽配体
EP3645549A1 (en) 2017-06-26 2020-05-06 BicycleRD Limited Bicyclic peptide ligands with detectable moieties and uses thereof
JP7670481B2 (ja) 2017-08-04 2025-04-30 バイスクルテクス・リミテッド Ｃｄ１３７に対して特異的な二環式ペプチドリガンド
CN111902429A (zh) 2018-02-23 2020-11-06 拜斯科技术开发有限公司 多聚体双环肽配体
IL279489B2 (en) 2018-06-22 2025-10-01 Bicycletx Ltd Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate
GB201820325D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for psma
GB201820288D0 (en) 2018-12-13 2019-01-30 Bicycle Tx Ltd Bicycle peptide ligaands specific for MT1-MMP
GB201820295D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for MT1-MMP
WO2020128527A1 (en) 2018-12-21 2020-06-25 Bicyclerd Limited Bicyclic peptide ligands specific for pd-l1
US12492224B2 (en) 2018-12-21 2025-12-09 Bicycletx Limited Bicyclic peptide ligands specific for PD-L1
GB201900529D0 (en) 2019-01-15 2019-03-06 Bicycletx Ltd Bicyclic peptide ligands specific for CD38
TWI860386B (zh) 2019-07-30 2024-11-01 英商拜西可泰克斯有限公司 異質雙環肽複合物
AU2021322934A1 (en) 2020-08-03 2023-03-30 Bicycletx Limited Peptide-based linkers

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009098450A2 (en) * 2008-02-05 2009-08-13 Medical Research Council Methods and compositions
WO2018197509A1 (en) * 2017-04-24 2018-11-01 Bicyclerd Limited Modification of polypeptides
WO2019002842A1 (en) * 2017-06-26 2019-01-03 Bicyclerd Limited BICYCLIC PEPTIDE LIGANDS WITH DETECTABLE FRACTIONS AND USES THEREOF
JP2022546964A (ja) * 2019-08-28 2022-11-10 バイスクルテクス・リミテッド Ｐｂｐ結合二環式ペプチドリガンド

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1452868A2 (en) 2003-02-27 2004-09-01 Pepscan Systems B.V. Method for selecting a candidate drug compound
WO2006078161A1 (en) 2005-01-24 2006-07-27 Pepscan Systems B.V. Binding compounds, immunogenic compounds and peptidomimetics
JP2008220317A (ja) * 2007-03-15 2008-09-25 Meiji Seika Kaisha Ltd ペニシリン結合タンパク質（ｐｂｐ）３トランスペプチダーゼドメイン
CN107810190A (zh) * 2015-04-28 2018-03-16 洛桑联邦政府综合工科学校（Epfl) 酶活化因子XII (FXIIa)的新型抑制剂
CN106591265B (zh) * 2016-08-18 2019-08-13 武汉职业技术学院 一种青霉素结合蛋白及其应用

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009098450A2 (en) * 2008-02-05 2009-08-13 Medical Research Council Methods and compositions
WO2018197509A1 (en) * 2017-04-24 2018-11-01 Bicyclerd Limited Modification of polypeptides
WO2019002842A1 (en) * 2017-06-26 2019-01-03 Bicyclerd Limited BICYCLIC PEPTIDE LIGANDS WITH DETECTABLE FRACTIONS AND USES THEREOF
JP2022546964A (ja) * 2019-08-28 2022-11-10 バイスクルテクス・リミテッド Ｐｂｐ結合二環式ペプチドリガンド

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KAYCIE DEYLE; ET AL: "PHAGE SELECTION OF CYCLIC PEPTIDES FOR APPLICATION IN RESEARCH AND DRUG DEVELOPMENT", ACCOUNTS OF CHEMICAL RESEARCH, vol. VOL:50, NR:8, JPN5023005706, 18 July 2017 (2017-07-18), US, pages 1866 - 1874, ISSN: 0005512713 *
RIIKKA KYLVAJA; ET AL: "PENICILLIN BINDING PROTEIN 3 OF STAPHYLOCOCCUS AUREUS NCTC 8325-4 BINDS AND ACTIVATES 以下備考", BMC RESEARCH NOTES, vol. VOL:9, NR:1, JPN5023005708, December 2016 (2016-12-01), pages 389 - 1, ISSN: 0005512715 *
SANDER S VAN BERKEL; ET AL: "BINDING OF (5S)-PENICILLOIC ACID TO PENICILLIN BINDING PROTEIN 3", ACS CHEMICAL BIOLOGY, vol. VOL:8, NR:10, JPN5023005707, 18 October 2013 (2013-10-18), pages 2112 - 2116, ISSN: 0005512714 *

Also Published As

Publication number Publication date
US20230106511A1 (en) 2023-04-06
WO2021171029A1 (en) 2021-09-02
CN115443285A (zh) 2022-12-06
GB202002706D0 (en) 2020-04-08
EP4110791A1 (en) 2023-01-04

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