CN115443285A - 结合pbp3的双环肽配体 - Google Patents

结合pbp3的双环肽配体 Download PDF

Info

Publication number
CN115443285A
CN115443285A CN202180030647.7A CN202180030647A CN115443285A CN 115443285 A CN115443285 A CN 115443285A CN 202180030647 A CN202180030647 A CN 202180030647A CN 115443285 A CN115443285 A CN 115443285A
Authority
CN
China
Prior art keywords
seq
referred
bcy
iii
pwvegc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180030647.7A
Other languages
English (en)
Chinese (zh)
Inventor
M·巴姆福思
P·贝斯威克
L·陈
M·道森
R·多德斯
C·罗兰
M·斯金纳
K·V·里茨霍滕
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BicycleTx Ltd
Original Assignee
BicycleTx Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BicycleTx Ltd filed Critical BicycleTx Ltd
Publication of CN115443285A publication Critical patent/CN115443285A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
CN202180030647.7A 2020-02-26 2021-02-26 结合pbp3的双环肽配体 Pending CN115443285A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB2002706.6A GB202002706D0 (en) 2020-02-26 2020-02-26 Pbp3 binding bicyclic peptide ligands
GB2002706.6 2020-02-26
PCT/GB2021/050491 WO2021171029A1 (en) 2020-02-26 2021-02-26 Pbp3 binding bicyclic peptide ligands

Publications (1)

Publication Number Publication Date
CN115443285A true CN115443285A (zh) 2022-12-06

Family

ID=70108251

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180030647.7A Pending CN115443285A (zh) 2020-02-26 2021-02-26 结合pbp3的双环肽配体

Country Status (6)

Country Link
US (1) US20230106511A1 (https=)
EP (1) EP4110791A1 (https=)
JP (1) JP2023515567A (https=)
CN (1) CN115443285A (https=)
GB (1) GB202002706D0 (https=)
WO (1) WO2021171029A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107148425B (zh) 2014-10-29 2021-08-03 拜斯科阿迪有限公司 对mt1-mmp特异性的双环肽配体
EP3645549A1 (en) 2017-06-26 2020-05-06 BicycleRD Limited Bicyclic peptide ligands with detectable moieties and uses thereof
JP7670481B2 (ja) 2017-08-04 2025-04-30 バイスクルテクス・リミテッド Ｃｄ１３７に対して特異的な二環式ペプチドリガンド
CN111902429A (zh) 2018-02-23 2020-11-06 拜斯科技术开发有限公司 多聚体双环肽配体
IL279489B2 (en) 2018-06-22 2025-10-01 Bicycletx Ltd Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate
GB201820325D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for psma
GB201820288D0 (en) 2018-12-13 2019-01-30 Bicycle Tx Ltd Bicycle peptide ligaands specific for MT1-MMP
GB201820295D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for MT1-MMP
WO2020128527A1 (en) 2018-12-21 2020-06-25 Bicyclerd Limited Bicyclic peptide ligands specific for pd-l1
US12492224B2 (en) 2018-12-21 2025-12-09 Bicycletx Limited Bicyclic peptide ligands specific for PD-L1
GB201900529D0 (en) 2019-01-15 2019-03-06 Bicycletx Ltd Bicyclic peptide ligands specific for CD38
TWI860386B (zh) 2019-07-30 2024-11-01 英商拜西可泰克斯有限公司 異質雙環肽複合物
AU2021322934A1 (en) 2020-08-03 2023-03-30 Bicycletx Limited Peptide-based linkers

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008220317A (ja) * 2007-03-15 2008-09-25 Meiji Seika Kaisha Ltd ペニシリン結合タンパク質（ｐｂｐ）３トランスペプチダーゼドメイン
CN106591265A (zh) * 2016-08-18 2017-04-26 武汉职业技术学院 一种青霉素结合蛋白及其应用
WO2019002842A1 (en) * 2017-06-26 2019-01-03 Bicyclerd Limited BICYCLIC PEPTIDE LIGANDS WITH DETECTABLE FRACTIONS AND USES THEREOF
CN114829374B (zh) * 2019-08-28 2025-04-04 拜斯科技术开发有限公司 结合pbp的双环肽配体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1452868A2 (en) 2003-02-27 2004-09-01 Pepscan Systems B.V. Method for selecting a candidate drug compound
WO2006078161A1 (en) 2005-01-24 2006-07-27 Pepscan Systems B.V. Binding compounds, immunogenic compounds and peptidomimetics
EP2653545A1 (en) 2008-02-05 2013-10-23 Bicycle Therapeutics Limited Methods and compositions
CN107810190A (zh) * 2015-04-28 2018-03-16 洛桑联邦政府综合工科学校（Epfl) 酶活化因子XII (FXIIa)的新型抑制剂
GB201706477D0 (en) * 2017-04-24 2017-06-07 Bicycle Therapeutics Ltd Modification of polypeptides

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008220317A (ja) * 2007-03-15 2008-09-25 Meiji Seika Kaisha Ltd ペニシリン結合タンパク質（ｐｂｐ）３トランスペプチダーゼドメイン
CN106591265A (zh) * 2016-08-18 2017-04-26 武汉职业技术学院 一种青霉素结合蛋白及其应用
WO2019002842A1 (en) * 2017-06-26 2019-01-03 Bicyclerd Limited BICYCLIC PEPTIDE LIGANDS WITH DETECTABLE FRACTIONS AND USES THEREOF
CN114829374B (zh) * 2019-08-28 2025-04-04 拜斯科技术开发有限公司 结合pbp的双环肽配体

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KAYCIE DEYLE: "Phage Selection of Cyclic Peptides for Application in Research and Drug Development", ACCOUNTS OF CHEMICAL RESEARCH, vol. 50, no. 8, 18 July 2017 (2017-07-18) *
程元荣: "青霉素结合蛋白与β-内酰胺抗生素的耐药机制", 中国抗生素杂志, no. 04, 28 August 1988 (1988-08-28) *

Also Published As

Publication number Publication date
US20230106511A1 (en) 2023-04-06
WO2021171029A1 (en) 2021-09-02
JP2023515567A (ja) 2023-04-13
GB202002706D0 (en) 2020-04-08
EP4110791A1 (en) 2023-01-04

Similar Documents

Publication Publication Date Title
CN114829374B (zh) 结合pbp的双环肽配体
CN115443285A (zh) 结合pbp3的双环肽配体
CN115551551A (zh) 抗感染双环肽缀合物
AU2019398516B2 (en) Bicyclic peptide ligands specific for MT1-MMP
CN113474047B (zh) Mt1-mmp特异性的双环肽配体
CN113518648B (zh) Mt1-mmp特异性的双环肽配体
US10654897B2 (en) β-hairpin peptidomimetics
WO2014188178A1 (en) Polymyxin derivatives and their use in combination therapy together with different antibiotics
US10829520B2 (en) Beta-hairpin peptidomimetics
WO2021220011A1 (en) Anti-infective bicyclic peptide conjugates
US10259847B2 (en) Beta-hairpin peptidomimetics
EA046810B1 (ru) Бициклические пептидные лиганды, специфичные к mt1-mmp
EA046487B1 (ru) Бициклические пептидные лиганды, специфичные к mt1-mmp
CN107108702A (zh) 基于乳链菌肽的化合物及其在治疗细菌感染中的用途

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination