JP2023515202A - 免疫抑制薬を含む合成ナノキャリアを使用する方法および組成物 - Google Patents

免疫抑制薬を含む合成ナノキャリアを使用する方法および組成物 Download PDF

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JP2023515202A
JP2023515202A JP2022551589A JP2022551589A JP2023515202A JP 2023515202 A JP2023515202 A JP 2023515202A JP 2022551589 A JP2022551589 A JP 2022551589A JP 2022551589 A JP2022551589 A JP 2022551589A JP 2023515202 A JP2023515202 A JP 2023515202A
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Prior art keywords
disease
subject
immunosuppressive drug
synthetic nanocarrier
synthetic
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JP2022551589A
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Japanese (ja)
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JP2023515202A5 (https=
Inventor
イリインスキー，ペトル
キシモト，タカシ，ケイ
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Cartesian Therapeutics Inc
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Selecta Biosciences Inc
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Priority claimed from PCT/US2020/028132 external-priority patent/WO2021211100A1/en
Application filed by Selecta Biosciences Inc filed Critical Selecta Biosciences Inc
Publication of JP2023515202A publication Critical patent/JP2023515202A/ja
Publication of JP2023515202A5 publication Critical patent/JP2023515202A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2022551589A 2020-02-26 2021-02-26 免疫抑制薬を含む合成ナノキャリアを使用する方法および組成物 Pending JP2023515202A (ja)

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
US202062981606P 2020-02-26 2020-02-26
US202062981586P 2020-02-26 2020-02-26
US202062981594P 2020-02-26 2020-02-26
US202062981602P 2020-02-26 2020-02-26
US202062981595P 2020-02-26 2020-02-26
US202062981584P 2020-02-26 2020-02-26
US202062981589P 2020-02-26 2020-02-26
US202062981612P 2020-02-26 2020-02-26
US62/981,589 2020-02-26
US62/981,594 2020-02-26
US62/981,595 2020-02-26
US62/981,612 2020-02-26
US62/981,606 2020-02-26
US62/981,586 2020-02-26
US62/981,584 2020-02-26
US62/981,602 2020-02-26
PCT/US2020/028132 WO2021211100A1 (en) 2020-04-14 2020-04-14 Methods and compositions for inducing autophagy
USPCT/US2020/028132 2020-04-14
PCT/US2021/019927 WO2021174013A1 (en) 2020-02-26 2021-02-26 Methods and compositions using synthetic nanocarriers comprising immunosuppressant

Publications (2)

Publication Number Publication Date
JP2023515202A true JP2023515202A (ja) 2023-04-12
JP2023515202A5 JP2023515202A5 (https=) 2024-03-06

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JP2022551589A Pending JP2023515202A (ja) 2020-02-26 2021-02-26 免疫抑制薬を含む合成ナノキャリアを使用する方法および組成物

Country Status (10)

Country Link
US (1) US20210290601A1 (https=)
EP (1) EP4110334A1 (https=)
JP (1) JP2023515202A (https=)
KR (1) KR20220146559A (https=)
CN (1) CN115379839A (https=)
AU (1) AU2021225955A1 (https=)
CA (1) CA3173734A1 (https=)
IL (1) IL295868A (https=)
MX (1) MX2022010568A (https=)
WO (1) WO2021174013A1 (https=)

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MX374963B (es) 2011-04-29 2025-03-06 Selecta Biosciences Inc Nanoportadores sintéticos tolerogénicos para reducir las respuestas de anticuerpos.
BR122020023215B1 (pt) 2013-05-03 2022-11-22 Selecta Biosciences, Inc Composição e kit de nanocarreadores sintéticos tolerogênicos para reduzir ou prevenir anafilaxia em resposta a um antígeno não alergênico
ES3036482T3 (en) 2017-03-11 2025-09-19 Cartesian Therapeutics Inc Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant
AU2020287627A1 (en) 2019-06-04 2021-11-18 Selecta Biosciences, Inc. Formulations and doses of PEGylated uricase
IL297274A (en) * 2020-04-14 2022-12-01 Selecta Biosciences Inc Methods and compositions for inducing autophagy
ES2986744A1 (es) * 2023-04-13 2024-11-12 Servicio Andaluz De Salud Rapamicina y estatinas como protectores frente daño hepático
CN117860782B (zh) * 2024-03-11 2024-05-28 中国康复科学所(中国残联残疾预防与控制研究中心) 双阴性t细胞在制备治疗脊髓损伤的药物中的用途

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Also Published As

Publication number Publication date
US20210290601A1 (en) 2021-09-23
AU2021225955A1 (en) 2022-09-22
CN115379839A (zh) 2022-11-22
CA3173734A1 (en) 2021-09-02
IL295868A (en) 2022-10-01
EP4110334A1 (en) 2023-01-04
KR20220146559A (ko) 2022-11-01
MX2022010568A (es) 2022-11-30
WO2021174013A1 (en) 2021-09-02

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