JP2023513679A - 中枢神経系障害の治療のためのセロトニン作動性幻覚薬としてのシロシン誘導体 - Google Patents

中枢神経系障害の治療のためのセロトニン作動性幻覚薬としてのシロシン誘導体 Download PDF

Info

Publication number
JP2023513679A
JP2023513679A JP2022548056A JP2022548056A JP2023513679A JP 2023513679 A JP2023513679 A JP 2023513679A JP 2022548056 A JP2022548056 A JP 2022548056A JP 2022548056 A JP2022548056 A JP 2022548056A JP 2023513679 A JP2023513679 A JP 2023513679A
Authority
JP
Japan
Prior art keywords
atoms
substituted
hydrogen
available
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022548056A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023513679A5 (enExample
Inventor
スラッシ、アブデルマリク
アラウホ、ジョーセフ
Original Assignee
マインドセット ファーマ インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=77199666&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2023513679(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by マインドセット ファーマ インコーポレイテッド filed Critical マインドセット ファーマ インコーポレイテッド
Publication of JP2023513679A publication Critical patent/JP2023513679A/ja
Publication of JP2023513679A5 publication Critical patent/JP2023513679A5/ja
Priority to JP2025172009A priority Critical patent/JP2026010068A/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406—Neurotransmitters
    • G01N33/942—Serotonin, i.e. 5-hydroxy-tryptamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/30—Psychoses; Psychiatry

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2022548056A 2020-02-04 2021-02-04 中枢神経系障害の治療のためのセロトニン作動性幻覚薬としてのシロシン誘導体 Pending JP2023513679A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025172009A JP2026010068A (ja) 2020-02-04 2025-10-10 中枢神経系障害の治療のためのセロトニン作動性幻覚薬としてのシロシン誘導体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062969934P 2020-02-04 2020-02-04
US62/969,934 2020-02-04
PCT/CA2021/050123 WO2021155468A1 (en) 2020-02-04 2021-02-04 Psilocin derivatives as serotonergic psychedelic agents for the treatment of cns disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025172009A Division JP2026010068A (ja) 2020-02-04 2025-10-10 中枢神経系障害の治療のためのセロトニン作動性幻覚薬としてのシロシン誘導体

Publications (2)

Publication Number Publication Date
JP2023513679A true JP2023513679A (ja) 2023-04-03
JP2023513679A5 JP2023513679A5 (enExample) 2024-02-07

Family

ID=77199666

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2022548056A Pending JP2023513679A (ja) 2020-02-04 2021-02-04 中枢神経系障害の治療のためのセロトニン作動性幻覚薬としてのシロシン誘導体
JP2022548057A Pending JP2023513680A (ja) 2020-02-04 2021-02-04 中枢神経系障害の治療のためのセロトニン作動性幻覚薬としてのシロシン誘導体
JP2024015076A Pending JP2024054193A (ja) 2020-02-04 2024-02-02 中枢神経系障害の治療のためのセロトニン作動性幻覚薬としてのシロシン誘導体
JP2025172009A Pending JP2026010068A (ja) 2020-02-04 2025-10-10 中枢神経系障害の治療のためのセロトニン作動性幻覚薬としてのシロシン誘導体
JP2025243928A Pending JP2026053405A (ja) 2020-02-04 2025-12-09 中枢神経系障害の治療のためのセロトニン作動性幻覚薬としてのシロシン誘導体

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2022548057A Pending JP2023513680A (ja) 2020-02-04 2021-02-04 中枢神経系障害の治療のためのセロトニン作動性幻覚薬としてのシロシン誘導体
JP2024015076A Pending JP2024054193A (ja) 2020-02-04 2024-02-02 中枢神経系障害の治療のためのセロトニン作動性幻覚薬としてのシロシン誘導体
JP2025172009A Pending JP2026010068A (ja) 2020-02-04 2025-10-10 中枢神経系障害の治療のためのセロトニン作動性幻覚薬としてのシロシン誘導体
JP2025243928A Pending JP2026053405A (ja) 2020-02-04 2025-12-09 中枢神経系障害の治療のためのセロトニン作動性幻覚薬としてのシロシン誘導体

Country Status (12)

Country Link
US (10) US11427604B2 (enExample)
EP (2) EP4100390A4 (enExample)
JP (5) JP2023513679A (enExample)
KR (3) KR20220137083A (enExample)
CN (3) CN115427395A (enExample)
AU (2) AU2021215811A1 (enExample)
BR (2) BR112022015377A2 (enExample)
CA (2) CA3166933A1 (enExample)
IL (3) IL327334A (enExample)
MX (2) MX2022009527A (enExample)
PH (1) PH12022551981A1 (enExample)
WO (2) WO2021155470A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024508922A (ja) * 2021-03-02 2024-02-28 マインドセット ファーマ インコーポレイテッド セロトニン作動性薬に関係する障害の治療に有用なセロトニン作動性薬としてのインドール誘導体

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201907871D0 (en) 2019-06-03 2019-07-17 Small Pharma Ltd Therapeutic compositions
HRP20220797T1 (hr) 2019-11-07 2022-10-14 Small Pharma Ltd Spojevi
MX2022009527A (es) * 2020-02-04 2022-11-16 Mindset Pharma Inc Derivados de la psilocina como agentes psicodelicos serotoninergicos para el tratamiento de trastornos del snc.
IL297861A (en) 2020-05-08 2023-01-01 Psilera Inc Novel compositions of matter and pharmaceutical compositions
IL312785B2 (en) 2020-05-19 2026-06-01 Cybin Irl Ltd Deuterated tryptamine derivatives and methods of use
US11773062B2 (en) 2021-03-22 2023-10-03 Small Pharma Ltd Deuterated compounds
US12042564B2 (en) 2020-06-02 2024-07-23 Cybin Uk Ltd Therapeutic solid dosage forms
DK4172145T3 (da) 2020-06-30 2026-07-20 Reunion Neuroscience Inc Tryptamin-prodrugs som serotonin-receptor-aktivatorer til behandling af f.eks. depression
AU2021328726A1 (en) * 2020-08-21 2023-03-02 Compass Pathfinder Limited Novel psilocin derivatives having prodrug properties
US11406619B2 (en) 2020-08-28 2022-08-09 Small Pharma Ltd Injectable formulations
US11324762B2 (en) 2020-10-08 2022-05-10 Lennham Pharmaceuticals, Inc. Deuterated derivatives of psilocybin and uses thereof
WO2022115944A1 (en) 2020-12-01 2022-06-09 Magicmed Industries Inc. Carboxylated psilocybin derivatives and methods of using
EP4031529B1 (en) * 2020-12-01 2023-09-27 Small Pharma Ltd Deuterated or partially deuterated n,n-dimethyltryptamine compounds
US11660289B2 (en) 2020-12-01 2023-05-30 Small Pharma Ltd. Deuterated or partially deuterated N,N-dimethyltryptamine compounds
US12521370B2 (en) 2020-12-01 2026-01-13 Cybin Uk Ltd Inhalable formulations
WO2022120181A1 (en) * 2020-12-03 2022-06-09 Mydecine Innovations Group Inc. Novel psilocin analog compositions and methods of synthesizing the same
JP2024500397A (ja) * 2020-12-18 2024-01-09 コンパス パスファインダー リミテッド 治療用途のための修飾インドールアルカロイド
EP4126857A1 (en) 2021-01-15 2023-02-08 Beckley Psytech Limited Ergoline analogues
EP4277894A1 (en) 2021-01-15 2023-11-22 Beckley Psytech Limited Tryptamine analogues
WO2022155751A1 (en) 2021-01-22 2022-07-28 Magicmed Industries Inc. Prenylated psilocybin derivatives and methods of using
US11312684B1 (en) 2021-02-10 2022-04-26 Eleusis Therapeutics Us, Inc. Pharmaceutically acceptable salts of psilocin and uses thereof
US20220370413A1 (en) * 2021-03-06 2022-11-24 Mind Medicine, Inc. Formulations of psilocin that have enhanced stability
WO2022192097A1 (en) * 2021-03-06 2022-09-15 Mind Medicine, Inc. Formulations of psilocin that have enhanced stability
AU2022239825C1 (en) * 2021-03-18 2026-08-13 Cybin Irl Limited Psilocybin analogs, salts, compositions, and methods of use
CN117177959A (zh) * 2021-03-18 2023-12-05 赛本爱尔兰有限公司 裸头草碱类似物、盐、组合物和使用方法
US20240174607A1 (en) * 2021-03-18 2024-05-30 Cybin Irl Limited Psilocybin analogs, salts, compositions, and methods of use
US12611399B2 (en) 2021-05-04 2026-04-28 Definium Therapeutics US, Inc. Movement disorders
KR20240013170A (ko) 2021-05-25 2024-01-30 아타이 테라퓨틱스, 인크. 신규 n,n-디메틸트립타민 염 및 결정질 염 형태
WO2023018864A1 (en) 2021-08-12 2023-02-16 Psilosterics, Llc Hallucinogenic and non-hallucinogenic serotonin receptor agonists and methods of making and using the same
KR20240065084A (ko) * 2021-08-20 2024-05-14 테란 바이오사이언시스 인코포레이티드 사일로신의 전구약물 및 유도체 및 그의 용도
CA3229361A1 (en) * 2021-08-20 2023-02-23 Abdelmalik Slassi 3-cycloamino-indole compounds as serotonergic agents useful for the treatment of disorders related thereto
US11344564B1 (en) 2021-08-20 2022-05-31 Lennham Pharmaceuticals, Inc. Method of treatment based on reduced monoamine oxidase a activity
US11697638B2 (en) 2021-09-08 2023-07-11 Small Pharma Ltd 5-methoxy-N,N-dimethyltryptamine crystalline forms
WO2023077245A1 (en) * 2021-11-08 2023-05-11 Nova Mentis Life Science Corp. Diagnosing, monitoring and treating neurological disease with psychoactive tryptamine derivatives and mrna measurements
US12318477B2 (en) 2021-11-18 2025-06-03 Cybin Uk Ltd Injectable and inhalable formulations
AU2022408191B2 (en) * 2021-12-10 2025-05-15 Caamtech, Inc. Psilocybin derivatives
US20250051278A1 (en) * 2021-12-14 2025-02-13 Reunion Neuroscience, Inc. Tryptamine prodrugs
CA3238440A1 (en) 2021-12-30 2023-07-06 Atai Therapeutics, Inc. Dimethyltryptamine analogues as nitric oxide delivery drugs
WO2023133873A1 (en) * 2022-01-17 2023-07-20 Nokia Shanghai Bell Co., Ltd. Configuration for in-x subnetworks
WO2023168023A1 (en) 2022-03-04 2023-09-07 Reset Pharmaceuticals, Inc. Co-crystals or salts comprising psilocin
US12065404B2 (en) 2022-03-18 2024-08-20 Enveric Biosciences Canada Inc. C4-carboxylic acid-substituted tryptamine derivatives and methods of using
AU2023235712A1 (en) * 2022-03-18 2024-11-07 Enveric Biosciences Canada Inc. C4-substituted tryptamine derivatives and methods of using
WO2023214404A1 (en) * 2022-05-01 2023-11-09 Short Wave Pharma Inc. A mucoadhesive film comprising a pharmaceutically active agent and uses thereof
EP4522167A1 (en) 2022-05-10 2025-03-19 Mydecine Innovations Group Inc. Novel psilocin prodrug compounds and methods of synthesizing the same
US12264131B2 (en) 2022-08-19 2025-04-01 Beckley Psytech Limited Pharmaceutically acceptable salts and compositions thereof
CA3267605A1 (en) * 2022-09-12 2024-03-21 Bionxt Solutions Inc. PSILOCIN DERIVATIVES BASED ON AMINO ACIDS AND CARBOHYDRATES
WO2024145719A1 (en) * 2023-01-05 2024-07-11 Reunion Neuroscience Inc. Improved pharmacokinetics of tryptamine prodrugs
US20240269113A1 (en) * 2023-01-24 2024-08-15 Compass Pathfinder Limited 3-(2-(DIMETHYLAMINO)ETHYL)-1H-INDOL-4-yl DERIVATIVES
US12396981B2 (en) 2023-03-09 2025-08-26 William Shulman Methods of using DMT
EP4704833A2 (en) * 2023-04-27 2026-03-11 ATAI Therapeutics, Inc. Alkoxy and carbamoyl quaternary amine salts as prodrugs of trpytamines
US12246005B2 (en) 2023-06-13 2025-03-11 Beckley Psytech Limited 5-methoxy-n,n-dimethyltryptamine (5-MeO-DMT) formulations
CN121793958A (zh) * 2023-06-27 2026-04-03 帕多瓦大学 使用二甲-4-羟色胺磷酸的联合疗法
JP2026524104A (ja) 2023-06-28 2026-07-17 サイロ プロプリエタリー リミテッド 化合物
EP4735441A1 (en) 2023-06-28 2026-05-06 Psylo Pty Ltd Pyrrolopyridine compounds for the treatment of mental illnesses
EP4746873A1 (en) * 2023-07-19 2026-05-27 ATAI Therapeutics, Inc. Novel prodrugs and conjugates of dimethyltryptamine and methods of using the same
TW202519206A (zh) * 2023-11-06 2025-05-16 大陸商宜昌人福藥業有限責任公司 一種n,n-二甲基色胺衍生物及其藥物組合物、製備方法和用途
WO2025104491A1 (en) 2023-11-14 2025-05-22 Mindset Pharma Inc. Indole derivatives as serotonergic agents useful for the treatment of disorders related thereto
US12310974B1 (en) 2023-12-19 2025-05-27 Samuel Aballea Method of treating post-traumatic stress disorder with carpipramine
WO2025238416A1 (en) * 2024-05-16 2025-11-20 Mindset Pharma Inc. Indole derivatives, uses and compositions thereof
WO2026024591A1 (en) * 2024-07-22 2026-01-29 Reunion Neuroscience, Inc. Tryptamine prodrug solid forms

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005062985A2 (en) * 2003-12-23 2005-07-14 American Bioscience, Inc. Di-ester prodrugs of camptothecin, process for their preparation and their therapeutical applications
JP2008514629A (ja) * 2004-09-27 2008-05-08 オーガニックス インコーポレイティッド セロトニン選択性薬剤として有用なインドール化合物
WO2011019738A1 (en) * 2009-08-10 2011-02-17 Galenea Corporation Compounds and methods of use thereof
JP2011511810A (ja) * 2008-02-11 2011-04-14 オーガニクス インコーポレイテッド インドール化合物およびその使用方法
WO2019067696A1 (en) * 2017-09-27 2019-04-04 Ohio State Innovation Foundation METHODS AND COMPOSITIONS FOR INHIBITING STAT3
WO2019081764A1 (en) * 2017-10-26 2019-05-02 Consejo Superior De Investigaciones Científicas (Csic) ASSOCIATION PRODUCT FOR THE TREATMENT OF NEUROLOGICAL AND / OR PSYCHIATRIC DISORDERS

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1242318A (en) 1913-12-20 1917-10-09 Sam Brest Ash sifter and receptacle.
US3075992A (en) 1958-09-12 1963-01-29 Sandoz Ltd Esters of indoles
US3078214A (en) * 1958-09-12 1963-02-19 Sandoz Ag Treatment of mental disturbances with esters of indoles
CH373381A (de) 1959-07-13 1963-11-30 Sandoz Ag Verfahren zur Herstellung neuer basischer Indol-Derivate
CH386422A (de) 1960-03-30 1965-01-15 Sandoz Ag Verfahren zur Herstellung neuer Ester der Indol-Reihe
GB981192A (en) 1960-03-30 1965-01-20 Westminster Bank Ltd Improvements in or relating to 4 hydroxytryptamine esters
GB933286A (en) 1961-03-23 1963-08-08 Lodge Cottrell Ltd Improvements in and relating to electro-precipitation
CH414639A (de) * 1961-10-20 1966-06-15 Sandoz Ag Verfahren zur Herstellung neuer heterocyclischer Verbindungen
US3202675A (en) 1961-10-26 1965-08-24 Sterling Drug Inc 1-benzyl-2, 5-bis (chloromethyl) pyrrolidine and acid-addition salts thereof
BE615395A (enExample) 1962-03-21
GB990092A (en) 1962-10-24 1965-04-22 Roche Products Ltd Novel indole derivatives and a process for the manufacture thereof
US7429575B2 (en) 2006-01-10 2008-09-30 Yu Ruey J N-(phosphonoalkyl)-amino acids, derivatives thereof and compositions and methods of use
EP2014662A1 (de) * 2007-07-12 2009-01-14 Bayer Schering Pharma Aktiengesellschaft Indolylalkylthienopyrimidylamine als Modulatoren des EP2-Rezeptors
EP2149552A1 (de) * 2008-07-30 2010-02-03 Bayer Schering Pharma AG 5,6 substituierte Benzamid-Derivate als Modulatoren des EP2-Rezeptors
EP2149551A1 (de) * 2008-07-30 2010-02-03 Bayer Schering Pharma AG N-(Indol-3-ylalkyl)-(hetero)arylamidderivate als Modulatoren des EP2-Rezeptors
RU2016129380A (ru) * 2013-12-20 2018-01-25 СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Замещенные диаминопиримидильные соединения, их композиции и способы лечения с их участием
ES2882588T3 (es) 2015-03-31 2021-12-02 Turtle Bear Holdings Llc Actividad antiviral de setas medicinales y sus constituyentes activos
WO2016205304A1 (en) * 2015-06-16 2016-12-22 Signal Pharmaceuticals, Llc Methods of treatment using substituted diaminopyrimidyl compounds
CZ307719B6 (cs) 2015-12-31 2019-03-20 Vysoká škola chemicko-technologická v Praze Použití derivátu tryptaminu
US20180021326A1 (en) 2016-07-23 2018-01-25 Paul Edward Stamets Compositions and methods for enhancing neuroregeneration and cognition by combining mushroom extracts containing active ingredients psilocin or psilocybin with erinacines or hericenones enhanced with niacin
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
US12090145B2 (en) 2018-08-20 2024-09-17 Yale University Combination therapy for treating or preventing depression or other mood diseases
MX2021009037A (es) 2019-01-30 2021-10-13 Diamond Therapeutics Inc Composiciones y metodos para el manejo de trastornos.
US12616706B2 (en) 2019-03-07 2026-05-05 Arbormentis LLC Compositions and methods of use comprising substances with neural plasticity actions administered at non-psychedelic/psychotomimetic dosages and formulations
GB201907871D0 (en) 2019-06-03 2019-07-17 Small Pharma Ltd Therapeutic compositions
HRP20220797T1 (hr) 2019-11-07 2022-10-14 Small Pharma Ltd Spojevi
US20230021957A1 (en) 2019-12-04 2023-01-26 Neonmind Biosciences Inc. Use of psilocin, psilocybin or analogs thereof in weight loss, treatment of obesity and compulsive eating disorder
MX2022009527A (es) * 2020-02-04 2022-11-16 Mindset Pharma Inc Derivados de la psilocina como agentes psicodelicos serotoninergicos para el tratamiento de trastornos del snc.
US20210236523A1 (en) 2020-02-05 2021-08-05 Yale University Psychedelic treatment for headache disorders
KR20230005367A (ko) 2020-05-04 2023-01-09 트러스티즈 오브 터프츠 칼리지 뇌 전달을 위한 합성 지질-유사 물질
IL312785B2 (en) 2020-05-19 2026-06-01 Cybin Irl Ltd Deuterated tryptamine derivatives and methods of use
US20220169606A1 (en) 2020-12-01 2022-06-02 Small Pharma Ltd. Compositions and compounds for bioanalysis
WO2021116503A2 (en) 2020-06-02 2021-06-17 Small Pharma Ltd Deuterated compounds
US20220168274A1 (en) 2020-12-01 2022-06-02 Small Pharma Ltd. Parenteral Formulation
DK4172145T3 (da) 2020-06-30 2026-07-20 Reunion Neuroscience Inc Tryptamin-prodrugs som serotonin-receptor-aktivatorer til behandling af f.eks. depression
JP2023539113A (ja) 2020-08-18 2023-09-13 サイビン アイアールエル リミテッド フェネチルアミン誘導体、組成物およびその使用方法
AU2021328726A1 (en) * 2020-08-21 2023-03-02 Compass Pathfinder Limited Novel psilocin derivatives having prodrug properties
EP4138818B1 (en) 2020-08-28 2024-08-21 Cybin UK Ltd Injectable formulation
US11324762B2 (en) 2020-10-08 2022-05-10 Lennham Pharmaceuticals, Inc. Deuterated derivatives of psilocybin and uses thereof
US11000534B1 (en) 2020-10-08 2021-05-11 Lennham Pharmaceuticals, Inc. Deuterated derivatives of psilocybin and uses thereof
EP4031529B1 (en) 2020-12-01 2023-09-27 Small Pharma Ltd Deuterated or partially deuterated n,n-dimethyltryptamine compounds
EP4255421A1 (en) 2020-12-01 2023-10-11 Small Pharma Ltd Inhalable formulations
WO2022120181A1 (en) * 2020-12-03 2022-06-09 Mydecine Innovations Group Inc. Novel psilocin analog compositions and methods of synthesizing the same
CA3201913A1 (en) * 2020-12-09 2022-06-16 Andrew R. Chadeayne Dialkyl trytamines and their therapeutic uses
JP2024500397A (ja) * 2020-12-18 2024-01-09 コンパス パスファインダー リミテッド 治療用途のための修飾インドールアルカロイド

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005062985A2 (en) * 2003-12-23 2005-07-14 American Bioscience, Inc. Di-ester prodrugs of camptothecin, process for their preparation and their therapeutical applications
JP2008514629A (ja) * 2004-09-27 2008-05-08 オーガニックス インコーポレイティッド セロトニン選択性薬剤として有用なインドール化合物
JP2011511810A (ja) * 2008-02-11 2011-04-14 オーガニクス インコーポレイテッド インドール化合物およびその使用方法
WO2011019738A1 (en) * 2009-08-10 2011-02-17 Galenea Corporation Compounds and methods of use thereof
WO2019067696A1 (en) * 2017-09-27 2019-04-04 Ohio State Innovation Foundation METHODS AND COMPOSITIONS FOR INHIBITING STAT3
WO2019081764A1 (en) * 2017-10-26 2019-05-02 Consejo Superior De Investigaciones Científicas (Csic) ASSOCIATION PRODUCT FOR THE TREATMENT OF NEUROLOGICAL AND / OR PSYCHIATRIC DISORDERS

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
F. HASLER ET AL.: "Determination of psilocin and 4-hydroxyindole-3-acetic acid in plasma by HPLC-ECD and pharmacokineti", PHARMACEUTICA ACTA HELVETIAE, vol. 72, JPN6025000150, 1997, pages 175 - 184, ISSN: 0005779366 *
GLOB J PHARMACEU SCI, vol. 1(4), JPN6023024906, 2017, pages 79 - 90, ISSN: 0005614082 *
HOWARD SARD ET AL.: "SAR of psilocybin analogs: Discovery of a selective 5-HT2C agonist", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, JPN6025000149, 2005, pages 4555 - 4559, ISSN: 0005779365 *
J. PHARM. SCI., vol. 64, JPN6014001782, 1975, pages 367 - 391, ISSN: 0005779369 *
MARTIN K. MADSEN ET AL.: "Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin", NEUROPSYCHOPHARMACOLOGY, vol. 44, JPN6025000151, 2019, pages 1328 - 1334, ISSN: 0005779367 *
NATURE MEDICINE, vol. 19(6), JPN6023024908, 2013, pages 656, ISSN: 0005614080 *
NATURE, vol. ４５８, JPN6014001781, 19 May 2009 (2009-05-19), pages ２６９, ISSN: 0005614081 *
WAKO ORGANIC SQUARE, vol. 33, JPN6022007129, 2010, pages 2 - 4, ISSN: 0005614079 *
佐藤 健太郎: "化学よもやま話 重水素", ＴＣＩメール, JPN6025000152, 2013, pages 2 - 5, ISSN: 0005779368 *
製剤学・物理薬剤学, JPN6018001718, 2012, pages 259 - 266, ISSN: 0005779370 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024508922A (ja) * 2021-03-02 2024-02-28 マインドセット ファーマ インコーポレイテッド セロトニン作動性薬に関係する障害の治療に有用なセロトニン作動性薬としてのインドール誘導体

Also Published As

Publication number Publication date
US20260116901A1 (en) 2026-04-30
KR20220137083A (ko) 2022-10-11
CA3166936A1 (en) 2021-08-12
IL327334A (en) 2026-05-01
IL295364B2 (en) 2026-08-01
US12054505B2 (en) 2024-08-06
CA3166933A1 (en) 2021-08-12
US20250388611A1 (en) 2025-12-25
JP2023513680A (ja) 2023-04-03
IL295364B1 (en) 2026-04-01
IL295371A (en) 2022-10-01
IL295364A (en) 2022-10-01
US20240317782A1 (en) 2024-09-26
IL295371B1 (en) 2026-04-01
US20230118872A1 (en) 2023-04-20
US11597738B2 (en) 2023-03-07
IL295371B2 (en) 2026-08-01
US12378266B2 (en) 2025-08-05
KR20240023678A (ko) 2024-02-22
AU2021217424A1 (en) 2022-09-01
US20220024956A1 (en) 2022-01-27
US11427604B2 (en) 2022-08-30
US11591353B2 (en) 2023-02-28
WO2021155468A1 (en) 2021-08-12
US20220289774A1 (en) 2022-09-15
BR112022015377A2 (pt) 2022-09-27
US20230203070A1 (en) 2023-06-29
US20220324889A1 (en) 2022-10-13
US20220017549A1 (en) 2022-01-20
MX2022009526A (es) 2022-11-08
AU2021215811A1 (en) 2022-09-01
CN115974757A (zh) 2023-04-18
WO2021155470A1 (en) 2021-08-12
KR20220137081A (ko) 2022-10-11
EP4100390A1 (en) 2022-12-14
US20230167141A1 (en) 2023-06-01
JP2024054193A (ja) 2024-04-16
EP4100391A4 (en) 2024-02-21
BR112022015375A2 (pt) 2022-09-27
CN115427395A (zh) 2022-12-02
MX2022009527A (es) 2022-11-16
JP2026010068A (ja) 2026-01-21
EP4100390A4 (en) 2024-06-12
PH12022551981A1 (en) 2023-10-16
EP4100391A1 (en) 2022-12-14
CN115397810A (zh) 2022-11-25
JP2026053405A (ja) 2026-03-25

Similar Documents

Publication Publication Date Title
JP2023513680A (ja) 中枢神経系障害の治療のためのセロトニン作動性幻覚薬としてのシロシン誘導体
JP2023512821A (ja) 中枢神経系障害の治療のためのセロトニン作動性幻覚薬としての３－ピロリジンインドール誘導体
US20240166630A1 (en) Indole derivatives as serotonergic agents useful for the treatment of disorders related thereto
JP2023553094A (ja) 中枢神経系障害の治療のためのセロトニン作動性薬としての３位環－アミンインドール誘導体
AU2022328466A1 (en) 3-cycloamino-indole compounds as serotonergic agents useful for the treatment of disorders related thereto
HK40084439A (en) Psilocin derivatives as serotonergic psychedelic agents for the treatment of cns disorders
HK40091505A (en) Psilocin derivatives as serotonergic psychedelic agents for the treatment of cns disorders
HK40105243A (en) Indole derivatives as serotonergic agents useful for the treatment of disorders related thereto
HK40083780A (en) Psilocin derivatives as serotonergic psychedelic agents for the treatment of cns disorders

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20221014

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A525

Effective date: 20221004

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240130

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20240130

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20241219

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20250114

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20250610

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20251010

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20251112