JP2023511443A - 普遍的免疫受容体を発現する操作された細胞の活性の量的制御 - Google Patents

普遍的免疫受容体を発現する操作された細胞の活性の量的制御 Download PDF

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JP2023511443A
JP2023511443A JP2022544775A JP2022544775A JP2023511443A JP 2023511443 A JP2023511443 A JP 2023511443A JP 2022544775 A JP2022544775 A JP 2022544775A JP 2022544775 A JP2022544775 A JP 2022544775A JP 2023511443 A JP2023511443 A JP 2023511443A
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cells
agent
mammal
cell
antigen
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ジェイ．，ジュニア． パウエル，ダニエル
トゥールカス，アンドリュー
ミヌトロー，ニコラス
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ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016135291A1 (en) * 2015-02-26 2016-09-01 Var2 Pharmaceuticals Aps Immunotherapeutic targeting of placental-like chondroitin sulfate using chimeric antigen receptors (cars) and immunotherapeutic targeting of cancer using cars with split-protein binding systems
WO2017112784A1 (en) * 2015-12-22 2017-06-29 The Trustees Of The University Of Pennsylvania Spycatcher and spytag: universal immune receptors for t cells

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WO2016126608A1 (en) * 2015-02-02 2016-08-11 Novartis Ag Car-expressing cells against multiple tumor antigens and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016135291A1 (en) * 2015-02-26 2016-09-01 Var2 Pharmaceuticals Aps Immunotherapeutic targeting of placental-like chondroitin sulfate using chimeric antigen receptors (cars) and immunotherapeutic targeting of cancer using cars with split-protein binding systems
WO2017112784A1 (en) * 2015-12-22 2017-06-29 The Trustees Of The University Of Pennsylvania Spycatcher and spytag: universal immune receptors for t cells

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CANCER RES, vol. Vol.79, No.13_Suppl., Article No.2317, JPN6025007153, 2019, pages 1 - 4, ISSN: 0005722430 *
京府医大誌, vol. 124, no. 12, JPN6025007152, 2015, pages 849 - 859, ISSN: 0005722431 *

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