BR112022014540A2 - Controle quantitativo da atividade de células modificadas que expressam receptores imunológicos universais - Google Patents
Controle quantitativo da atividade de células modificadas que expressam receptores imunológicos universaisInfo
- Publication number
- BR112022014540A2 BR112022014540A2 BR112022014540A BR112022014540A BR112022014540A2 BR 112022014540 A2 BR112022014540 A2 BR 112022014540A2 BR 112022014540 A BR112022014540 A BR 112022014540A BR 112022014540 A BR112022014540 A BR 112022014540A BR 112022014540 A2 BR112022014540 A2 BR 112022014540A2
- Authority
- BR
- Brazil
- Prior art keywords
- activity
- universal immune
- quantitative control
- express
- modified cells
- Prior art date
Links
Classifications
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
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- C07K2317/00—Immunoglobulins specific features
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- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C—CHEMISTRY; METALLURGY
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- C07K2319/00—Fusion polypeptide
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062965593P | 2020-01-24 | 2020-01-24 | |
| PCT/US2021/014811 WO2021151038A1 (en) | 2020-01-24 | 2021-01-23 | Quantitative control of activity of engineered cells expressing universal immune receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112022014540A2 true BR112022014540A2 (pt) | 2022-09-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| BR112022014540A BR112022014540A2 (pt) | 2020-01-24 | 2021-01-23 | Controle quantitativo da atividade de células modificadas que expressam receptores imunológicos universais |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230103327A1 (https=) |
| EP (1) | EP4093412A4 (https=) |
| JP (1) | JP2023511443A (https=) |
| KR (1) | KR20220132577A (https=) |
| CN (1) | CN115397439A (https=) |
| AU (1) | AU2021209950A1 (https=) |
| BR (1) | BR112022014540A2 (https=) |
| CA (1) | CA3168878A1 (https=) |
| IL (1) | IL295036A (https=) |
| MX (1) | MX2022009146A (https=) |
| WO (1) | WO2021151038A1 (https=) |
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| IL310386A (en) * | 2021-07-28 | 2024-03-01 | Prescient Therapeutics Ltd | Universal receptor immune cell therapy |
| GB202306808D0 (en) * | 2023-05-09 | 2023-06-21 | Univ Oxford Innovation Ltd | Method for detecting interactions |
| WO2024241208A1 (ko) * | 2023-05-19 | 2024-11-28 | 서울대학교산학협력단 | Cd3 유전자 편집된 cd3 표적 스위처블 car-t 세포 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2016126608A1 (en) * | 2015-02-02 | 2016-08-11 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
| EP3262063B1 (en) * | 2015-02-26 | 2021-09-22 | Var2 Pharmaceuticals ApS | Immunotherapeutic targeting of placental-like chondroitin sulfate using chimeric antigen receptors (cars) and immunotherapeutic targeting of cancer using cars with split-protein binding systems |
| US11377481B2 (en) * | 2015-12-22 | 2022-07-05 | The Trustees Of The University Of Pennsylvania | SpyCatcher and SpyTag: universal immune receptors for T cells |
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2021
- 2021-01-23 CN CN202180023901.0A patent/CN115397439A/zh active Pending
- 2021-01-23 US US17/794,571 patent/US20230103327A1/en active Pending
- 2021-01-23 KR KR1020227029186A patent/KR20220132577A/ko active Pending
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- 2021-01-23 WO PCT/US2021/014811 patent/WO2021151038A1/en not_active Ceased
- 2021-01-23 BR BR112022014540A patent/BR112022014540A2/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2023511443A (ja) | 2023-03-17 |
| US20230103327A1 (en) | 2023-04-06 |
| KR20220132577A (ko) | 2022-09-30 |
| CA3168878A1 (en) | 2021-07-29 |
| EP4093412A1 (en) | 2022-11-30 |
| AU2021209950A1 (en) | 2022-09-01 |
| WO2021151038A1 (en) | 2021-07-29 |
| CN115397439A (zh) | 2022-11-25 |
| EP4093412A4 (en) | 2024-11-06 |
| IL295036A (en) | 2022-09-01 |
| MX2022009146A (es) | 2022-10-27 |
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