JP2023511282A - シュウ酸塩が有害となる障害を治療するための遺伝子改変細菌 - Google Patents

シュウ酸塩が有害となる障害を治療するための遺伝子改変細菌 Download PDF

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JP2023511282A
JP2023511282A JP2022542946A JP2022542946A JP2023511282A JP 2023511282 A JP2023511282 A JP 2023511282A JP 2022542946 A JP2022542946 A JP 2022542946A JP 2022542946 A JP2022542946 A JP 2022542946A JP 2023511282 A JP2023511282 A JP 2023511282A
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oxalate
gene
encoding
sequence
day
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JP2023511282A5 (https=
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ヴィンセント エム． イザベラ，
デイビッド ルブコウィッツ，
マイケル ジェイムズ，
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Synlogic Inc
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Synlogic Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y208/00—Transferases transferring sulfur-containing groups (2.8)
    • C12Y208/03—CoA-transferases (2.8.3)
    • C12Y208/03016—Formyl-CoA transferase (2.8.3.16)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01002—Oxalate decarboxylase (4.1.1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01008—Oxalyl-CoA decarboxylase (4.1.1.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y602/00—Ligases forming carbon-sulfur bonds (6.2)
    • C12Y602/01—Acid-Thiol Ligases (6.2.1)
    • C12Y602/01008—Oxalate--CoA ligase (6.2.1.8)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
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  • Biochemistry (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2022542946A 2020-01-14 2021-01-14 シュウ酸塩が有害となる障害を治療するための遺伝子改変細菌 Pending JP2023511282A (ja)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US202062960950P 2020-01-14 2020-01-14
US62/960,950 2020-01-14
US202062993301P 2020-03-23 2020-03-23
US62/993,301 2020-03-23
US202063028902P 2020-05-22 2020-05-22
US63/028,902 2020-05-22
US202063065752P 2020-08-14 2020-08-14
US63/065,752 2020-08-14
US202063089758P 2020-10-09 2020-10-09
US63/089,758 2020-10-09
US202063091620P 2020-10-14 2020-10-14
US63/091,620 2020-10-14
US202063111376P 2020-11-09 2020-11-09
US63/111,376 2020-11-09
PCT/US2021/013401 WO2021146397A1 (en) 2020-01-14 2021-01-14 Bacteria engineered to treat disorders in which oxalate is detrimental

Publications (2)

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JP2023511282A true JP2023511282A (ja) 2023-03-17
JP2023511282A5 JP2023511282A5 (https=) 2024-01-22

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JP2022542946A Pending JP2023511282A (ja) 2020-01-14 2021-01-14 シュウ酸塩が有害となる障害を治療するための遺伝子改変細菌

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US (1) US20230092431A1 (https=)
EP (1) EP4090343A4 (https=)
JP (1) JP2023511282A (https=)
CN (1) CN115335066A (https=)
AU (1) AU2021207879A1 (https=)
BR (1) BR112022013867A2 (https=)
CA (1) CA3167754A1 (https=)
IL (1) IL294710A (https=)
WO (1) WO2021146397A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3203975A1 (en) 2020-12-03 2022-06-09 Battelle Memorial Institute Polymer nanoparticle and dna nanostructure compositions and methods for non-viral delivery
WO2022204406A1 (en) * 2021-03-24 2022-09-29 Synlogic Operating Company, Inc. Bacteria engineered to treat disorders in which oxalate is detrimental
CA3216359A1 (en) 2021-04-07 2022-10-13 Battelle Memorial Institute Rapid design, build, test, and learn technologies for identifying and using non-viral carriers
GB202402011D0 (en) 2024-02-14 2024-03-27 Snipr Biome Aps A novel type of crispr/cas system
AU2024353375A1 (en) 2023-09-29 2026-04-09 Battelle Memorial Institute Polymer nanoparticle compositions for in vivo expression of polypeptides
WO2025122954A1 (en) 2023-12-08 2025-06-12 Battelle Memorial Institute Use of dna origami nanostructures for molecular information based data storage systems

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003500451A (ja) * 1999-05-28 2003-01-07 ブイエスエル・ファーマ・リミテッド 高シュウ酸尿症の予防または処置用の食養生または医薬組成物
JP2009519333A (ja) * 2005-12-14 2009-05-14 オクセラ インコーポレイテッド シュウ酸塩関連疾患を治療または予防するための医薬組成物および方法
WO2017040719A1 (en) * 2015-08-31 2017-03-09 Synlogic, Inc. Bacteria engineered to treat disorders in which oxalate is detrimental
WO2019014391A1 (en) * 2017-07-12 2019-01-17 Synlogic Operating Company, Inc. MICROORGANISMS PROGRAMMED TO PRODUCE IMMUNOMODULATORS AND ANTICANCER THERAPEUTIC AGENTS IN TUMOR CELLS

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9283252B2 (en) * 2008-09-30 2016-03-15 Meiji Co., Ltd. Lactic acid bacterium having high oxalic acid decomposition ability
EP3468572B1 (en) * 2016-06-13 2022-03-02 OxThera Intellectual Property AB Compositions and methods for the treatment or prevention of oxalate-related disorders
CN111655841A (zh) * 2017-06-21 2020-09-11 同生运营公司 用于治疗紊乱的细菌
IT201800005355A1 (it) * 2018-05-14 2019-11-14 Lactobacillus amylovorus SGL 14: attività probiotiche e riduzione dell’ossalato enterico

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003500451A (ja) * 1999-05-28 2003-01-07 ブイエスエル・ファーマ・リミテッド 高シュウ酸尿症の予防または処置用の食養生または医薬組成物
JP2009519333A (ja) * 2005-12-14 2009-05-14 オクセラ インコーポレイテッド シュウ酸塩関連疾患を治療または予防するための医薬組成物および方法
WO2017040719A1 (en) * 2015-08-31 2017-03-09 Synlogic, Inc. Bacteria engineered to treat disorders in which oxalate is detrimental
WO2019014391A1 (en) * 2017-07-12 2019-01-17 Synlogic Operating Company, Inc. MICROORGANISMS PROGRAMMED TO PRODUCE IMMUNOMODULATORS AND ANTICANCER THERAPEUTIC AGENTS IN TUMOR CELLS

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
UROLITHIASIS, vol. 46, JPN6024041441, 2018, pages 313 - 323, ISSN: 0005563179 *

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Publication number Publication date
BR112022013867A2 (pt) 2022-09-13
WO2021146397A1 (en) 2021-07-22
EP4090343A4 (en) 2024-02-14
US20230092431A1 (en) 2023-03-23
AU2021207879A1 (en) 2022-09-08
IL294710A (en) 2022-09-01
CA3167754A1 (en) 2021-07-22
CN115335066A (zh) 2022-11-11
EP4090343A1 (en) 2022-11-23

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