JP2023504795A5 - - Google Patents
Info
- Publication number
- JP2023504795A5 JP2023504795A5 JP2022531434A JP2022531434A JP2023504795A5 JP 2023504795 A5 JP2023504795 A5 JP 2023504795A5 JP 2022531434 A JP2022531434 A JP 2022531434A JP 2022531434 A JP2022531434 A JP 2022531434A JP 2023504795 A5 JP2023504795 A5 JP 2023504795A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrazole
- quinoline
- acetamide
- pyridine
- diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025116497A JP2025163046A (ja) | 2019-11-28 | 2025-07-10 | トランスフォーミング増殖因子－β受容体Ｉ／ＡＬＫ５の阻害剤としてのベンジルアミド誘導体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19383057.7 | 2019-11-28 | ||
| EP19383057 | 2019-11-28 | ||
| PCT/EP2020/083566 WO2021105317A1 (en) | 2019-11-28 | 2020-11-27 | Benzylamide derivatives as inhibitors of transforming growth factor-beta receptor i/alk5 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025116497A Division JP2025163046A (ja) | 2019-11-28 | 2025-07-10 | トランスフォーミング増殖因子－β受容体Ｉ／ＡＬＫ５の阻害剤としてのベンジルアミド誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023504795A JP2023504795A (ja) | 2023-02-07 |
| JP2023504795A5 true JP2023504795A5 (cg-RX-API-DMAC7.html) | 2023-12-06 |
| JP7808032B2 JP7808032B2 (ja) | 2026-01-28 |
Family
ID=68808255
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022531434A Active JP7808032B2 (ja) | 2019-11-28 | 2020-11-27 | トランスフォーミング増殖因子－β受容体Ｉ／ＡＬＫ５の阻害剤としてのベンジルアミド誘導体 |
| JP2025116497A Pending JP2025163046A (ja) | 2019-11-28 | 2025-07-10 | トランスフォーミング増殖因子－β受容体Ｉ／ＡＬＫ５の阻害剤としてのベンジルアミド誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025116497A Pending JP2025163046A (ja) | 2019-11-28 | 2025-07-10 | トランスフォーミング増殖因子－β受容体Ｉ／ＡＬＫ５の阻害剤としてのベンジルアミド誘導体 |
Country Status (15)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3978487A1 (en) | 2020-09-30 | 2022-04-06 | Origo Biopharma, S.L. | 2-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-1-yl)-acetamide derivatives as inhibitors of transforming growth factor-beta receptor i/alk5 |
| AU2025225502A1 (en) | 2024-02-22 | 2026-07-30 | Agomab Spain S.L.U. | Crystalline phase forms of a benzylamide derivative |
| WO2026082960A1 (en) | 2024-10-18 | 2026-04-23 | Agomab Therapeutics Nv | 1,5-naphtyridine and quinoline based inhibitors of alk5 |
| WO2026082968A1 (en) | 2024-10-18 | 2026-04-23 | Agomab Therapeutics Nv | Novel compounds |
| CN122036718A (zh) * | 2026-01-30 | 2026-05-15 | 安炎达医药技术(广州)有限公司 | 一种alk5抑制剂及其制备方法和应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3621540A1 (de) | 1986-06-27 | 1988-01-07 | Basf Ag | Chinolinderivate, verfahren zu ihrer herstellung, diese enthaltende mikrobizide und ihre verwendung zur bekaempfung von bakterien und pilzen |
| ATE291020T1 (de) * | 2001-02-02 | 2005-04-15 | Smithkline Beecham Corp | Pyrazolderivate gegen tgf überexprimierung |
| WO2004026306A2 (en) | 2002-09-18 | 2004-04-01 | Pfizer Products Inc. | Pyrazole derivatives as transforming growth factor (tgf) inhibitors |
| WO2004026302A1 (en) * | 2002-09-19 | 2004-04-01 | Eli Lilly And Company | Methods of inhibiting tgf beta with substituted pyrazoles |
| CL2004000234A1 (es) * | 2003-02-12 | 2005-04-15 | Biogen Idec Inc | Compuestos derivados 3-(piridin-2-il)-4-heteroaril-pirazol sustituidos, antagonistas de aik5 y/o aik4; composicion farmaceutica y uso del compuesto en el tratamiento de desordenes fibroticos como esclerodermia, lupus nefritico, cicatrizacion de herid |
| CN102056907B (zh) | 2008-04-04 | 2014-12-31 | 武田药品工业株式会社 | 杂环衍生物及其用途 |
| US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
| WO2011076725A1 (en) | 2009-12-21 | 2011-06-30 | Bayer Cropscience Ag | Thienylpyri (mi) dinylazole and their use for controlling phytopathogenic fungi |
| RU2612958C2 (ru) * | 2011-07-13 | 2017-03-14 | Ск Кемикалз Ко., Лтд. | 2-пиридилзамещенные имидазолы в качестве ингибиторов alk5 и/или alk4 |
| US11021468B2 (en) * | 2015-04-01 | 2021-06-01 | Rigel Pharmaceuticals, Inc. | TGF-ß inhibitors |
| WO2016172631A2 (en) | 2015-04-24 | 2016-10-27 | President And Fellows Of Harvard College | Substrate selective inhibitors of insulin-degrading enzyme (ide) and uses thereof |
| KR102434226B1 (ko) * | 2016-06-30 | 2022-08-19 | 한미약품 주식회사 | Alk5 억제제로서의 신규 피라졸 유도체 및 이의 용도 |
| JP2021518855A (ja) | 2018-03-02 | 2021-08-05 | ユニヴェルシテ ド ローザンヌ | Ｗｎｔシグナル伝達経路阻害剤としてのピラゾール誘導体 |
| US11945803B2 (en) | 2018-08-07 | 2024-04-02 | Tosk, Inc. | Modulators of RAS GTPase |
| CN110433164A (zh) * | 2019-08-15 | 2019-11-12 | 南开大学 | TGF-beta受体分子抑制剂在治疗小鼠动物模型中急性髓系白血病的应用 |
| EP3978487A1 (en) | 2020-09-30 | 2022-04-06 | Origo Biopharma, S.L. | 2-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-1-yl)-acetamide derivatives as inhibitors of transforming growth factor-beta receptor i/alk5 |
-
2020
- 2020-11-27 BR BR112022010251A patent/BR112022010251A2/pt unknown
- 2020-11-27 AR ARP200103298A patent/AR120578A1/es unknown
- 2020-11-27 IL IL293388A patent/IL293388B2/en unknown
- 2020-11-27 PH PH1/2022/551177A patent/PH12022551177A1/en unknown
- 2020-11-27 CA CA3160963A patent/CA3160963A1/en active Pending
- 2020-11-27 MX MX2022005843A patent/MX2022005843A/es unknown
- 2020-11-27 AU AU2020394531A patent/AU2020394531B2/en active Active
- 2020-11-27 WO PCT/EP2020/083566 patent/WO2021105317A1/en not_active Ceased
- 2020-11-27 CN CN202080080848.3A patent/CN114787145B/zh active Active
- 2020-11-27 EP EP20811359.7A patent/EP4065572A1/en active Pending
- 2020-11-27 ES ES20811359T patent/ES3029608T1/es active Pending
- 2020-11-27 US US17/780,099 patent/US12297186B2/en active Active
- 2020-11-27 JP JP2022531434A patent/JP7808032B2/ja active Active
-
2022
- 2022-05-10 ZA ZA2022/05149A patent/ZA202205149B/en unknown
- 2022-05-26 SA SA522432749A patent/SA522432749B1/ar unknown
-
2025
- 2025-05-06 US US19/200,279 patent/US20250333395A1/en active Pending
- 2025-07-10 JP JP2025116497A patent/JP2025163046A/ja active Pending
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